Publication Bias in Literature on Antidepressants for Autism

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Researchers at the University of Michigan reviewed published and unpublished trials of serotonin receptor inhibitors (SRI) for the treatment of autism spectrum disorders (ASD)....

Researchers Push to End Placebo Run-in Periods in Antidepressant Studies

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Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.

Antidepressants Increase Risk of Death in ICU

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An analysis of electronic records from admissions to four ICU's in 2001-2008 showed that the 1,876 patients who were on an SSRI or SNRI...

Study Finds SSRIs Associated with Increased Risk for Violent Crime

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Study finds an apparent connection between SSRIs, the most commonly prescribed type of antidepressant, and increased risk of violent crime.

Researcher Critiques Misleading Claims About Antidepressants

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Recent claims about antidepressant effectiveness have been based on misleading statements and misunderstandings of the science.

SSRIs Increase Post-Surgical Complications

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A study of 530,000 patients who underwent surgery at 375 U.S. hospitals found a 10% increased risk of post-operative complications including bleeding, transfusion, hospital...

Antidepressants & Sexual Function

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Two studies of the effects of antidepressants on sexual function - one on the relative effects across classes of antidepressants on men, the other...

Adverse Reactions to Psychiatric Medications Hospitalize 17,000 Annually

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Nearly 90,000 American adults are going to emergency rooms every year in response to adverse events from psychiatric medications, according to a study in...

Childhood Trauma Predicts Lack of Response to Antidepressants

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Research in Translational Psychiatry finds that childhood maltreatment and trauma predict a greater likelihood of developing chronic depression, and a reduced likelihood of responding to treatment...

Poverty, Pathology and Pills: An Interview with Dr. Felicity Thomas and Dr. Richard Byng

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MIA’s Tim Beck interviews Dr. Felicity Thomas and Dr. Richard Byng about their report, Poverty, Pathology, and Pills, which situates increasing rates of mental health diagnosis and psychiatric prescriptions within socioeconomic and policy trends across the UK.

Adding Fluoxetine to Therapy Not Superior to Therapy Alone in Depressed Teens

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The addition of fluoxetine to CBT did not further reduce depressive symptoms in young people with moderate-to-severe depression.
VA Secretary Robert Wilkie

An Open Letter to VA Secretary Robert Wilkie: A Plan for Deprescribing Veteran Suicides

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Through my research and experiences, I've found that what the Veterans Administration has been doing to fight the veteran suicide epidemic isn't working and appears to be unintentionally exacerbating it. These problems are fixable. But I need your help.

Citizens Petition Calls for Sexual Side Effect Warnings

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Researchers take action after study exposes enduring sexual dysfunction as a potential side effect of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors, and isotretinoin.

Psychotherapy Less Effective for People in Poverty and Those on Antidepressants

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A new study finds poorer depression and anxiety outcomes in psychotherapy for people in economically deprived neighborhoods and those on antidepressants.

Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds

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Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

SSRIs Can Impair New Learning About Anxiety

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Researchers from Columbia University and the New York State Psychiatric Institute test the behavioral effects of SSRIs on Pavlovian fear conditioning in rats, and...
guy holding pill

New Review: Antidepressants Come with Minimal Benefits, Several Risks

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A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.
Bored young man, staring out the train window on a rainy, grey and dull day

Patient Reports Reveal SSRI Antidepressants Often Lead to Emotional Blunting

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According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.

Many People Taking Antidepressants Don’t Have Any Mental Disorders

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The majority of people taking antidepressant medications have never had major depressive disorder, and 38% have never met criteria for having any mental disorder.

Children Taking ADHD Drugs More Likely to Take Antidepressants as Teens

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Adhering to a commonly prescribed medication for ADHD in children is associated with higher chances of being prescribed antidepressants in adolescence.

Less Than a Quarter of Those with Depression Respond to Treatment in Real Life

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In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

How Antidepressants Shape Young Women’s Sense of Self

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Young women’s narratives indicate ways antidepressants have shaped their sense of self.

Majority of Anorexia Patients are Prescribed Psychotropics Despite Lack of Data

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Research from the medical schools of Harvard University and the University of Melbourne, reported in the December International Journal of Eating Disorders, found that...

Antidepressants Not Clinically Useful for Back Pain

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While professional guidelines recommend antidepressants for back pain, researchers point out the lack of evidence for their usefulness.