NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal
A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.
Gradual Tapering Recommended for Antidepressant Discontinuation
A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.
Clinical Trials Underreport Harms of Antidepressant Medications
A group of researchers recently found serious bias in the reporting of harm due to adverse events in antidepressant medication clinical trials. They report...
Therapy Gets More Effective Over Time While Antidepressants Decrease in Effectiveness
New review of long-term depression data finds psychotherapy more effective over time whereas antidepressants decrease in effectiveness.
CBT More Cost-Effective Than SSRI for Panic Disorder
A two-year study of 150 panic-disorder patients found that the societal cost of cognitive-behavioral was less than that of CBT plus SSRI or SSRI...
Antidepressants Overprescribed to Post-Menopausal Women Despite Risks
A new study reveals that antidepressants, commonly prescribed to post-menopausal women, may increase risks of falls, cognitive decline, and cardiovascular issues, raising questions about their overuse in this population.
Antidepressants Not Clinically Useful for Back Pain
While professional guidelines recommend antidepressants for back pain, researchers point out the lack of evidence for their usefulness.
High Doses of Antidepressants Increase Self-Harm in Children, Young Adults
A comprehensive meta-analysis of randomized trial data by researchers from the Harvard School of Public Health finds that children and young adults who start...
Antidepressant Withdrawal Linked to Suicide Attempt in Case Study
Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.
Study Finds SSRIs Associated with Increased Risk for Violent Crime
Study finds an apparent connection between SSRIs, the most commonly prescribed type of antidepressant, and increased risk of violent crime.
Most Off-Label Prescribing of Antidepressants Lacks Strong Scientific Evidence
A new study, published in the British Medical Journal, investigates the prevalence of off-label prescribing for antidepressant medication in primary care settings.
Antidepressants Associated With Increased Driving Risk
Researchers from the Taiwan and the United States find through a study of 5,183 subjects with motor vehicle accidents (MVAs) and 31,093 matched controls...
Animal Study: SSRI Neurotoxic in Pregnancy
Researchers: Fetal exposure to vilazodone hampers neurodevelopment and leads to "long-lasting neurodevelopmental impairments."
How to Distinguish Antidepressant Withdrawal from Relapse
Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.
Long Term Antidepressant Use Associated With Increased Morbidity and Mortality
A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.
Over 1,000 Antidepressant Users Describe how Their Personal Life has Been Affected
Survey examines adverse personal and interpersonal effects of antidepressants and the impact of polypharmacy
Increased Bone Fracture Risk from SSRI Antidepressants
"Evidence from longitudinal, cross-sectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density...
Antidepressant Use May Increase Risk of Diabetes
New study confirms previous evidence that antidepressant use is linked to developing type 2 diabetes.
Anticholinergic Drugs, Including Antidepressants, Linked To Later Cognitive Problems
A new study, published in JAMA Neurology, found that older people who regularly took anticholinergic drugs, including certain cold medicines or antidepressants, had poorer...
Antidepressants Seem to Increase Heart Disease in the Elderly
Depressed elderly people are more likely to suffer heart disease not because of their depression, but apparently due to antidepressant drugs.
Antidepressants Double Death Risk in Intensive Care
Analysis of 10,568 critically ill patients' records by Beth Israel Deaconess Medical Center and MIT finds that those on antidepressants were almost twice as...
Slew of New Studies Spot Links Between Psychiatric Medications and Bone Loss, Fractures
Four different studies conducted in different ways examining different groups have linked use of certain psychiatric drugs to bone fracture risks and negative impacts on human bone development.
The Whistleblower and Penn: A Final Accounting of Study 352
After 18 years, the full story of the scientific corruption in a study of paroxetine for bipolar disorder, and the psychiatrist who blew the whistle.
Health Risks to Babies When Antidepressants Used During Pregnancy
Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.
Researchers Set the Record Straight on Controversial Zoloft Study
An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).
