No, the FDA’s Black Box Warning Did not Increase Suicides

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Researchers again debunk the claim that the FDA black box warnings on antidepressants led to more suicides.

Antidepressants Linked to Heart Arrhythmias

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Researchers from the Mass General and Brigham & Women's Hospitals and the Mt. Sinai School of Medicine find, using data from electronic health records...

Antidepressants Linked to Doubling of Failure of Dental Implants

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People who take SSRI antidepressants are twice as likely to have their dental implants fail, according to McGill University researchers. In a press release,...

Paxil Linked to Birth Defects, Cardiac Malformations

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According to the CDC, January is National Birth Defects Prevention Month. New research continues to link various SSRI antidepressants with birth defects and neurological abnormalities in newborns. The latest study to examine this topic, a meta-analysis led by Dr. Anick Bérard, found a 23% increased risk for birth defects, and a 28% increased risk for heart problems, in the infants of women who took the SSRI Paxil (paroxetine) during their first trimester.

SSRIs Significantly Increase Falls in Dementia, Even at Low Doses

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Researchers in the Netherlands followed 248 nursing home residents with dementia for two years, finding that even 25% of the defined daily dose of...

“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Adverse Emotional and Interpersonal Effects of Antidepressants

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Adverse effects of antidepressants, including sexual difficulties and emotional numbing, apathy, suicidality and withdrawal effects may be more frequent than previously reported, according to...

What Animal Research Says About Sexual Side-effects of SSRIs

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A group of researchers in Denmark examines what existing animal studies can tell us about the sexual side-effects of SSRI antidepressants.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

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A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Over 1,000 Antidepressant Users Describe how Their Personal Life has Been Affected

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Survey examines adverse personal and interpersonal effects of antidepressants and the impact of polypharmacy

Researchers Challenge Evidence for Antidepressants in Youth

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Researchers shed light on the precarious nature of evidence from efficacy trials of antidepressant medication to treat symptoms of major depressive disorder in children and adolescents.

Antidepressant Use Associated With More Violent Suicide Attempts

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A new study found that taking an antidepressant medication was associated with a heightened risk of suicide using violent means.

Clinical Trials Show Antidepressants “Not Beneficial in the Long Term”

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Clinical trials also consistently fail to measure and report long-term harmful effects.

Publication Bias in Literature on Antidepressants for Autism

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Researchers at the University of Michigan reviewed published and unpublished trials of serotonin receptor inhibitors (SRI) for the treatment of autism spectrum disorders (ASD)....

No Matter Which Measure You Use, Antidepressants Aren’t That Effective

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Researchers compared the efficacy of antidepressants using different rating scales and found them to be no different—just slightly better than placebo, and not meeting the criteria for clinical significance.

Study Finds Antidepressants in Pregnancy Increase Risk for Speech Disorders

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A new study published this week in JAMA Psychiatry indicates that infants are more likely to develop speech or language disorders if they are exposed to antidepressants during pregnancy.

Prescription Drugs May Cause One Third of All Birth Defects

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Up to a third of all birth defects may be linked to prescription drugs, according to a review of the evidence published in The...

Antidepressants Have No Effect On Bipolar Depression

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In a review of 68 articles published between 2005 and 2011, Israeli researchers found that most well-controlled studies failed to show a significant effect of...

Researchers Push to End Placebo Run-in Periods in Antidepressant Studies

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Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.

Antidepressants Double Death Risk in Intensive Care

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Analysis of 10,568 critically ill patients' records by Beth Israel Deaconess Medical Center and MIT finds that those on antidepressants were almost twice as...

Rigorous Study Finds Antidepressants Worsen Long-Term Outcomes

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A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.

Legal Journal Says Antidepressants Can Cause Violence and Suicide

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Antidepressants have been reported to cause a state called “akathisia,” where people feel extremely agitated and restless and may become preoccupied with thoughts of...

GSK to Face Class Action over Antidepressants for Children

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A Sydney, Australia law firm has launched a class action on behalf of people who as children and adolescents were prescribed Glaxosmithkline's drug Paroxetine. Despite...

More Evidence Antidepressants Might Induce Sexual Dysfunction Even After Stopping Them

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A retrospective study in the Journal of Clinical Psychiatry examined cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants.

Clinical Trials Underreport Harms of Antidepressant Medications

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A group of researchers recently found serious bias in the reporting of harm due to adverse events in antidepressant medication clinical trials. They report...