Paxil Boosts Estrogen, May Promote Breast Cancer Growth

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A trial of a new process of identifying drugs that can disrupt sex hormonesĀ singled out Paxil from 446 common drugs as having a weak...
guy holding pill

New Review: Antidepressants Come with Minimal Benefits, Several Risks

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A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.

Researchers Challenge Evidence for Antidepressants in Youth

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Researchers shed light on the precarious nature of evidence from efficacy trials of antidepressant medication to treat symptoms of major depressive disorder in children and adolescents.

Antidepressant use During Pregnancy may Increase Risk of Birth Defects

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Use of antidepressants increased the risk of organ-specific malformations in women with depression

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressants Double Death Risk in Intensive Care

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Analysis of 10,568 critically ill patients' records by Beth Israel Deaconess Medical Center and MIT finds that those on antidepressants were almost twice as...

SSRIs Significantly Increase Falls in Dementia, Even at Low Doses

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Researchers in the Netherlands followed 248 nursing home residents with dementia for two years, finding that even 25% of the defined daily dose of...

Could ‘Treatment Resistance’ be an Effect of Antidepressants?

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Previously taking antidepressants could make individuals less likely to respond to treatment for bipolar II depression.

Researchers Identify Patterns in Antidepressant and Long-Term Benzodiazepine Use

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The researchers found that, of those who were initially prescribed both antidepressants and benzodiazepines, approximately 12% went on to engage in long-term benzodiazepine use.

FDA: Antidepressant Trials Have Not Adequately Reported Sexual Dysfunction Side Effects

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US Food and Drug Administration scientists want to better evaluate side effects of sexual dysfunction associated with antidepressant drugs.

Psychotherapy Less Effective for People in Poverty and Those on Antidepressants

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A new study finds poorer depression and anxiety outcomes in psychotherapy for people in economically deprived neighborhoods and those on antidepressants.

Increased Risk of Preterm Birth in Women Taking Antidepressants

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A detailed meta-analysis of the published research on women taking antidepressants duringĀ pregnancyĀ finds that the rate of preterm birth is nearly doubled in the third...

Childhood Trauma Predicts Lack of Response to Antidepressants

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Research in Translational Psychiatry finds thatĀ childhood maltreatment and trauma predict a greater likelihood of developing chronic depression, and aĀ reduced likelihood of responding to treatment...

Study Links SSRIs to Violent Crime in Youth

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Individuals between the ages of 15 and 24 are more likely to commit a violent crime if they are taking an SSRI antidepressant than if they are not, according to new research out of Sweden. The study published in PLoS Medicine on Tuesday, suggests "warnings about the increased risk of violent behavior among young people taking SSRIs might be needed.ā€
A bottle of pills. Some are spilled out.

Antidepressant Use More Than Doubles Risk of Suicide Attempts

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Throughout the past two decades, studies have warned of increased suicide rates in those taking antidepressants, especially in children and adolescents. Researchers also documented...

Anticholinergic Medications Linked to Dementia Similar to Early Alzheimer’s

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A new study, published in the Journal of Clinical Psychiatry, investigates the effects of anticholinergic medications, such as antidepressants and antipsychotics, on cognition in older adults diagnosed with schizophrenia.

Reanalysis of Data Shows Antidepressant Impacts on Depression “Not Clinically Significant”

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Irving Kirsch and Joanna Moncrieff have reanalyzed the clinical trial data on antidepressants.

New Study Finds Limited Effectiveness for Antidepressants After Stroke

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The researchers found that although antidepressants had a slight short-term effect on reducing the likelihood of depression diagnosis, there was no long-term improvement, nor any improvement in motor functioning.

Antidepressants Cause Autism-Like Gene Expression in Fish

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Prozac, Effexor, and/or carbamazepine induce gene expression patterns in the brains of fathead minnows that mimic those thought to be associated with autism in...

Animals Exposed to Antidepressants in Utero Are Worse at Taking Care of Their Own...

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A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.

Gradual Tapering Recommended for Antidepressant Discontinuation

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A new literature review reinforces the need to ā€œdown-titrateā€ or taper antidepressants, especially drugs like Celexa and Paxil.

Antidepressants Have No Effect On Bipolar Depression

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In a reviewĀ of 68 articles published between 2005 and 2011, Israeli researchers found that most well-controlled studies failed to show a significant effect of...

Treating Anxiety by Tapering Off Antidepressants

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Researchers from Samaritan Mental Health in Corvallis, Oregon successfully treated 12 patients for anxiety by discontinuing their antidepressant medications. Some received alternative medications for...

Antidepressants Linked to Doubling of Failure of Dental Implants

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People who take SSRI antidepressants are twice as likely to have their dental implants fail, according to McGill University researchers. In a press release,...

Antidepressants Cause Cardiovascular Disease, Study Finds

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A new study published in BMJ Mental Health finds that antidepressants are associated with cardiovascular disease (CVD). The authors employed Mendelian randomization, a method...