Science of Psychiatric Drugs

Antidepressants Linked to Lasting Sexual Dysfunction, Study Finds

8
New research highlights the challenges in quantifying the prevalence of Post-SSRI Sexual Dysfunction (PSSD), a condition that continues to affect patients long after they stop taking antidepressants.

ADHD Drugs Linked to Psychosis and Mania

5
In one analysis, those on a high dose of prescription amphetamines were more than 13 times more likely to develop psychosis/mania.

Antidepressant Withdrawal: A Psychiatrist’s 30-Year Challenge to Conventional Wisdom

3
For thirty years, Dr. Giovanni Fava has sounded the alarm on the long-term effects of antidepressants and the risks of withdrawal, pushing back against pharmaceutical narratives.

Antidepressant Withdrawal Commonly Misdiagnosed as “Mental Illness”

3
A new study reveals that more than two-thirds of patients experiencing antidepressant withdrawal were misdiagnosed with psychiatric disorders.

Antidepressants Overprescribed to Post-Menopausal Women Despite Risks

3
A new study reveals that antidepressants, commonly prescribed to post-menopausal women, may increase risks of falls, cognitive decline, and cardiovascular issues, raising questions about their overuse in this population.

The Ethics of Antipsychotic Dose Reduction and Patient Rights

0
New research highlights the ethical responsibilities of clinicians in supporting patients who choose to reduce or discontinue antipsychotic medication.

Youth Antipsychotic Use Linked to Increased Risk of Death within Five Years

3
Those aged 18-24 had an increased risk of death within five years on doses above 100 mg chlorpromazine equivalents.

Antiseizure Drug Exposure in Pregnancy Linked to Large Risk of Autism, ADHD, and Intellectual...

5
Harms are “largely overlooked by psychiatry despite widespread usage,” according to the researchers.

Wunderink: Antipsychotics Can Be Tapered Safely Without Increasing Relapse Risk

7
Tapering antipsychotics slowly and with supported decision-making may improve care for patients with psychosis.

Case Studies Reveal Patient Empowerment Through Tapering Antipsychotics

1
A new study shows how different patients respond to tapering antipsychotic medication under expert guidance, highlighting personal empowerment and the complexities of withdrawal.

Long-Term Benzo Use Linked to Increased Disability

0
Despite guidance that the drugs should only be used short-term, about a third of patients indicated long-term benzo use.

When Medication Changes More Than Symptoms: Antipsychotics’ Effect on Identity

10
Recent research reveals how antipsychotic medications can significantly impact users' identity and self-image, challenging existing clinical approaches.

Antidepressant Trials “Hijacked for Marketing Purposes,” Researchers Say

34
About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.

Study Links Prenatal Antipsychotic Exposure to Developmental Delays and ADHD

2
A comprehensive review indicates that children exposed to antipsychotics in the womb face an increased risk of ADHD and developmental delays.

Long-term Outcomes Better for Those Who Stop Taking Antipsychotics

14
Research undermines the prolonged use of antipsychotics in schizophrenia treatment, suggesting improved social functioning and quality of life with discontinuation.

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

2
In this new study, exposure to maternal anxiety in utero also harmed child development.

Study Highlights Difficulty of Antipsychotic Withdrawal

0
New research finds insomnia, anxiety, and depression are common symptoms of antipsychotic withdrawal, highlighting difficulties of discontinuation.

Common Side Effects Leading to Antidepressant Discontinuation

1
New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressant Use Linked to Sexual Dysfunction, Why Aren’t Prescribers Discussing It?

1
Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.

Antidepressant Use Tightly Correlates with Increased Suicide Rates

4
While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.

Despite Safety Risks, Prescribers Receive Little Guidance of Monitoring Antipsychotic Clozapine

5
A new review finds a lack of available guidance on how to effectively monitor adverse effects of antipsychotic drug clozapine.
3D illustration of a matrix with tablets and the words risks and benefits. Concept of clinical trials results

Two Out of Three Find Antidepressant Effects Not Worth Burdens

1
New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.
Pattern of blue and yellow pills or tablets on a pink background. concept of medicine, pharmacy and coronavirus. copy space

SSRI Withdrawal has Social, Cognitive, and Emotional Consequences

0
New research finds that the non-physical aspects of withdrawal from SSRIs are often overlooked.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

1
A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...
3D render of placebo pills isolated over wood background

Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

15
In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.