Science of Psychiatric Drugs

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Peer-Support Groups Were Right, Guidelines Were Wrong: Dr. Mark Horowitz on Tapering Off Antidepressants

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In an interview with MIA, Dr. Horowitz discusses his recent article on why tapering off antidepressants can take months or even years.

Antidepressant Use Tightly Correlates with Increased Suicide Rates

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While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.

Antidepressant Use Linked to Sexual Dysfunction, Why Aren’t Prescribers Discussing It?

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Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.
Young man refusing to take prescribed pills in clinic

Antipsychotics Lead to Worse Outcomes in First-Episode Psychosis

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Those who did not get antipsychotics in the first month were almost twice as likely to be in recovery after five years.
Pattern of blue and yellow pills or tablets on a pink background. concept of medicine, pharmacy and coronavirus. copy space

SSRI Withdrawal has Social, Cognitive, and Emotional Consequences

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New research finds that the non-physical aspects of withdrawal from SSRIs are often overlooked.
3D illustration of a matrix with tablets and the words risks and benefits. Concept of clinical trials results

Two Out of Three Find Antidepressant Effects Not Worth Burdens

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New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.

A Short History of Tardive Dyskinesia: 65 Years of Drug-Induced Brain Damage That Rolls...

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Psychiatry has long turned a blind eye to the full scope of harm associated with TD. New TD drugs "work" by further impairing brain function.
3D render of placebo pills isolated over wood background

Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

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In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.

ADHD Drugs Linked to Cardiovascular Disease

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Service users taking drugs to treat ADHD may be at increased risk for hypertension and arterial disease

Antidepressants No Better Than Placebo for About 85% of People

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Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain

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A new study published in JAMA Psychiatry connects antipsychotics with damage to the brain in multiple areas.

Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues

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A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.

Antidepressants in Pregnancy: Risks to the Fetus and Long-term Health of the Child

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The research literature reveals that antidepressant use in pregnancy poses considerable risks to the fetus and the long-term health of the child. These risks include preterm birth, birth defects, abnormal brain development, and behavioral abnormalities in early childhood.

Recovery Rate Six Times Higher For Those Who Stop Antipsychotics Within Two Years

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People with "serious mental illness" who stop taking antipsychotics are more likely to recover, even when accounting for baseline severity.
Pile of pills in blister packs background

Psychiatric Journals’ Pro-Pharma Publication Bias Hides Suicide Risk of Antidepressants

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Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.

Surviving Antidepressants: An Interview with Adele Framer

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That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.

Lexapro for Children: Drug With No Meaningful Benefit and Increased Suicidality Gets FDA Approval

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Response and remission rates were the same in the drug versus placebo groups, and Lexapro increased suicidality sixfold.

Psychiatric Drugs Do Not Improve Disease or Reduce Mortality

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Nassir Ghaemi: “Most psychiatric medications are purely symptomatic, with no known or proven effect on the underlying disease. They are like 50 variations of aspirin, used for fever or headache, rather than drugs that treat the causes of fever or headache.”

Despite Safety Risks, Prescribers Receive Little Guidance of Monitoring Antipsychotic Clozapine

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A new review finds a lack of available guidance on how to effectively monitor adverse effects of antipsychotic drug clozapine.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

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A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...

Do Antipsychotics Protect Against Early Death? A Review of the Evidence

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Psychiatry is now claiming that research has shown that antipsychotics reduce mortality among the seriously mentally ill. A critical review of the literature reveals that this claim is best described as the the field's latest "delusion" about the merits of these drugs.

Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

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Experts advocate limiting antidepressant use to only the most severe cases of depression, emphasizing the need for social and psychological interventions.
Top View of Girl Sits on Bed with Scattered Pills. Little Child Sitting on Gray Badcover Near Opened Packing of Medicines Keeps Head with Hands. Unhappy Childhood Concept

Antidepressants Increase Suicide Attempts in Youth; No Preventative Effect

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Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

Suicide in the Age of Prozac

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During the past twenty years, the American Foundation for Suicide Prevention and American psychiatry have adopted a "medicalized" approach to preventing suicide, claiming that antidepressants are protective against suicide. Yet, the suicide rate in the United States has increased 30% since 2000, a time of rising usage of antidepressants. A review of studies of the effects of mental health treatment and antidepressants on suicide reveals why this medicalized approach has not only failed, but pushed suicide rates higher.