Scant Evidence for Combining Antipsychotics
Researchers in Barcelona, Spain retrospectively reviewed the use of antipsychotics in 117,811 patients, of whom 9,855 were given combinations of antipsychotics and 13,763 were...
Minimal Empirical Support for Antidepressant Treatment in Young People
Researchers from Australia reviewed the existing literature for good-quality evidence of effective prevention and treatment of depression in young people. Prevention research was dominated...
Antipsychotics are Common for the Mechanically Ventilated
Annals of Pharmacotherapy reports in a study of patients undergoing mechanical ventilation that 39% were given antipsychotic medication to prevent or treat delirium despite...
Stimulant Prescribing Patterns for ADHD Not Impacted by Scientific Evidence
The article suggests that research challenging the evidence for ADHD drugs does not lead to changes without public campaigns.
SSRI Withdrawal has Social, Cognitive, and Emotional Consequences
New research finds that the non-physical aspects of withdrawal from SSRIs are often overlooked.
SSRIs Cause Epilepsy in Rats
Researchers from Australia find that chronic treatment with SSRIs significantly increases the rate of epileptogenesis in rats. Although SSRIs are commonly prescribed to people...
No Difference in Antidepressant Effectiveness After Genetic Testing
Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.
Exposure to Antidepressants in the Womb Linked to Autism
Researchers, publishing in Toxicology Research, review the evidence that antidepressant exposure in the womb is linked to autism spectrum disorders (ASD) in humans.
Therapy Beats Drugs for Depression for Long-Term Outcomes
Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.
Suicide Attempts Similar With Various Antidepressants for Children
Researchers from Vanderbilt University and the University of Alabama found, in a retrospective study of increased suicidal behavior among 36,842 children who were new...
Short-Term SSRI Use Associated With Gastrointestinal Bleeding
Researchers find, through a review of records from the Taiwanese National Health Insurance Database from 1998 to 2009, that short-term (7-28 day) use of...
Antipsychotics Increase Mortality Risk in Patients with Parkinson’s Disease
A new study in JAMA Neurology finds that the use of antipsychotic drugs more than doubled the risk of death in patients with Parkinson’s...
Multiple Medications Associated With Poorer Outcomes
Research from Germany finds that people with schizophrenia or schizoaffective diagnoses given multiple medications - an antipsychotic plus a benzodiazepine or more than one...
PTSD and Antidepressants Linked to Diabetes
A JAMA Psychiatry study found links between PTSD, type 2 diabetes, and antidepressants.
Antipsychotics do not Result in Neurocognitive Improvement
Researchers in London and Spain, in a prospective, randomized, study of long-term (3 year) effects of first- and second-generation antipsychotics on neurocognition in 79...
‘Salami Slicing’ Found in Analyses of Antipsychotic Trials
Evidence of duplicate publishing in articles analyzing data from clinical trials testing second-generation antipsychotics for depression
Long-term Outcomes Better for Those Who Stop Taking Antipsychotics
Research undermines the prolonged use of antipsychotics in schizophrenia treatment, suggesting improved social functioning and quality of life with discontinuation.
Long-acting Injection No Better than Oral Antipsychotic
A study of 5-year outcomes for people taking either an ordinary oral antipsychotic or a long-acting injection of an antipsychotic found no differences between the two.
No Benefit for Adding Antidepressants to CBT in Severe Depression
For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.
Benzo Discontinuation Improves Quality of Life and Reduces Symptoms of Schizophrenia
Researchers in Japan find that tapering or reducing benzodiazepines has a positive effect on quality of life, verbal and working memory, and psychiatric symptoms...
Researchers Identify Patterns in Antidepressant and Long-Term Benzodiazepine Use
The researchers found that, of those who were initially prescribed both antidepressants and benzodiazepines, approximately 12% went on to engage in long-term benzodiazepine use.
Antidepressants Linked to Doubling of Failure of Dental Implants
People who take SSRI antidepressants are twice as likely to have their dental implants fail, according to McGill University researchers. In a press release,...
Review Finds Lack of Evidence for Antidepressants in Treatment of Insomnia
Results from a Cochrane meta-analysis find that the common practice of prescribing antidepressants to treat insomnia is not supported by current evidence.
Service-Users See Long-Term Antipsychotic Use as Compromising Recovery, Review Finds
A new meta-review examines the experiences of antipsychotic drugs use among people diagnosed with a psychotic disorder.
Industry Corruption in Systematic Review for Injectable Antipsychotics
Researchers highlight how systematic reviews are compromised by pharmaceutical industry ties by exposing a study of injectable antipsychotics.
