Depression related documents and drugs

Shifting Away from ECT and Antidepressants for Depression

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Researchers argue that we need a paradigm shift away from the biomedical model of mental illness to one informed by political action and common sense.

Negative Antidepressant Trials Still Unlikely to Be Published

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Antidepressant trials with negative results are still more likely than not to either be misleadingly spun as positive or unpublished.
Doctor attentively examines the MRI scan of the patient.

SSRI Antidepressants Do Not Improve Depression After a Stroke

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A study in JAMA Neurology finds that antidepressants do not reduce depression symptoms more than placebo in patients recovering from a stroke.
guy holding pill

New Review: Antidepressants Come with Minimal Benefits, Several Risks

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A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.

Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues

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A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.

Researchers Push to End Placebo Run-in Periods in Antidepressant Studies

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Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.

Withdrawal Symptoms Cloud Findings of Antidepressant ā€œRelapseā€ Trial

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Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

Giovanni Fava – A Different Psychiatry is Possible

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In this podcast, we hear from the renowned clinician and researcher Dr. Giovanni Fava about his latest book entitled ā€œDiscontinuing Antidepressant Medicationsā€.

New Rating Tool for Tapering Antidepressants and Antipsychotics

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Researchers developed a rating scale to better assess service usersā€™ experiences tapering antidepressant and/or antipsychotic medication.

Newborn Babies Go Through Antidepressant Withdrawal

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A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

ā€œRelapseā€ in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Researchers Propose Study to Test Whether Antidepressants Impede Recovery

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Evolutionary theorists suggest that antidepressants interfere with the adaptive function of depression and propose a test of this theory.

Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read

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A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.

No, the FDAā€™s Black Box Warning Did not Increase Suicides

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Researchers again debunk the claim that the FDA black box warnings on antidepressants led to more suicides.

Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants

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ā€œShort and simple psychological programs can prevent people from relapsing when they stop their antidepressants.ā€

Allen Frances Takes on the Over-Prescription of Antidepressants

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The prominent psychiatrist explores why antidepressants remain highly overprescribed and offers solutions to the problem.

Antidepressants Not Clinically Useful for Back Pain

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While professional guidelines recommend antidepressants for back pain, researchers point out the lack of evidence for their usefulness.

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

Internet Forum for Tapering Psychiatric Drugs Provides Novel Insights

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After 15 years, the founder of SurvivingAntidepressants.org, Adele Framer, shares what she has learned about the science of withdrawing from psychiatric drugs.

Antidepressant Withdrawal Misdiagnosed as Functional Disorder

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Adverse physiological symptoms of antidepressant withdrawal are regularly mistaken to be other problems to the detriment of the patient.

Antidepressants Still Linked to Increased Suicide Risk

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Bias and financial conflicts in antidepressant trials ā€œcontribute to systematic underestimation of risk in the published literature.ā€

Another Failed Study of ā€œPersonalizedā€ Depression Treatment

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Due to lackluster antidepressant study results, researchers test if subgroups of depressed patients show greater improvement.

Researchers Document Protracted Withdrawal from Antidepressants

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Protracted Withdrawal Syndrome characterized by long-term adverse experiences after coming off of antidepressants.

New Research Questions Safety of Esketamine for Depression

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An analysis of FDA adverse event reports related to esketamine shows the potential for negative effects such as suicidal and self-injurious ideation.

Researchers: ā€œAntidepressants Should Be Avoided in Bipolar Depressionā€

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New research finds that antidepressants are not effective for bipolar disorder and can worsen symptoms of mania.