Tag: SSRIs

It is hard to believe that a year has gone past since I posted Playing the Odds: Antidepressant Withdrawal and the Problem of Informed Consent. The feedback I received underscored the more controversial aspects of SSRI toxicity.  Common themes concerned the abrupt onset of new symptoms 3 to 12 months after stopping the drug, reinstatement of the drug failing to help withdrawal related symptoms, the possibility that withdrawal-related symptoms can persist indefinitely and concerns about using benzodiazepines to help with tardive akathisia.

A former Duke University psychiatry chair is calling for a retraction of a study suggesting that the FDA's black-box warnings about increased suicidality in youth taking SSRIs led to increases in adolescent suicide attempts.

A British Medical Journal study led by Harvard Medical School's Christine Lu suggested that black box warnings about increased suicidality in youth who take antidepressants actually led to increases in adolescent suicide attempts. However, the latest in a stream of critics of that conclusion are the authors of one of the key studies cited by Lu in support of her team's analysis.

A study that appeared online in the British Medical Journal suggests that the FDA’s warning in 2003 that antidepressants increase the risk of suicidal ideation in youth paradoxically  led to an increase in suicide attempts in this age group. Media reports on the study tell of how the black-box warning “backfired.” But is this conclusion warranted by the study? Or is the study flawed? And how did the media report on this story?

An issue that we think deserves more media attention than it is currently receiving is the idea of Preventive Intervention in Psychiatry. The goal of Preventive Intervention is to reduce the rate of psychiatric diagnoses in an at-risk group of people by pretreating all the group members with a medication. For instance, could the rate of PTSD in the military be reduced by pretreating everybody in the military with an SSRI?

The conventional wisdom is that antidepressant medications are effective and safe. However, the scientific literature shows that the conventional wisdom is flawed. While all prescription medications have side effects, antidepressant medications appear to do more harm than good as treatments for depression.