Research from Columbia University and the University of Pennsylvania, published in JAMA Psychiatry, finds that although practice guidelines recommend antipsychotics as a first-line treatment for obsessive compulsive disorder, 80 percent of patients receiving cognitive behavioral therapy for OCD responded with reduced symptoms and improved functioning and quality of life, whereas only 23 percent improved on risperidone. The study concludes that patients with OCD should be offered exposure and response prevention (EX/RP) therapy before antipsychotics “given EX/RP’s superior efficacy and less negative adverse effect profile.” The study’s lead author, speaking in the New York Times, says “It’s important to discontinue antipsychotics if there isn’t continued benefit after four weeks.” Results were published in JAMA Psychiatry.
Simpson, H., Foa, E., Liebowitz, M., Huppert, J.; Cognitive-Behavioral Therapy vs Risperidone for Augmenting Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder. JAMA Psychiatry. Online September 11, 2013. doi:10.1001/jamapsychiatry.2013.1932
Of further interest:
Behavior Therapy Aids Obsessive-Compulsive Disorder (NY Times)