Researchers Call for Reappraisal of Adverse Mental Effects of Antipsychotics, NIDS


In a study published yesterday, researchers from the Nippon Medical School in Tokyo bring attention to a condition known as neuroleptic-induced deficit syndrome (NIDS) brought on by the adverse mental effects of antipsychotic drugs. They express concern that NIDS can resemble the negative symptoms associated with schizophrenia and psychosis, leading to misdiagnosis and ineffective treatments.

In Neuropsychiatric Disease and Treatment, the researchers document three case studies where the psychiatrists of patients diagnosed with bipolar disorder failed to recognize NIDS symptoms as an adverse effect of neuroleptic antipsychotic drugs. In all of these cases, remission was eventually achieved after intensive therapy and a reduction in neuroleptic drugs.

They conclude:

“As long as antipsychotics are clinically used, whether typical or atypical, the recognition and differentiation of deficit status is needed for the treatment of bipolar disorder as well as schizophrenia. When taking this problem into consideration, it is clear that NIDS is becom­ing an increasingly important issue in pharmacotherapy. The authors believe that its concept should be reappraised in current clinical psychiatry.”



Ueda, S., Omori, A., Fukuta, H., Kobayashi, T., Sakayori, T., Ishizaka, K., … & Okubo, Y. (2013, December). NIDS (Neuroleptic-induced deficit syndrome) in bipolar disorder with psychosis: three cases of prolonged treatment course. In International Journal of Psychiatry in Clinical Practice(Vol. 17, pp. 36-36). TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND: INFORMA HEALTHCARE. (Full Text)

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Justin Karter
MIA Research News Editor: Justin M. Karter is the lead research news editor for Mad in America. He completed his doctorate in Counseling Psychology at the University of Massachusetts Boston. He also holds graduate degrees in both Journalism and Community Psychology from Point Park University. He brings a particular interest in examining and decoding cultural narratives of mental health and reimagining the institutions built on these assumptions.


  1. “Resemble the negative symptoms … leading to misdiagnosis and ineffective treatments.”

    ~ Captain Obvious on psychiatric drugs

    “No matter how today turns out, there’s always tomorrow.”
    ~ Captain Obvious on cheering you up

    “Simply because you can’t see something doesn’t mean you can’t hear or smell it.”
    ~ Captain Obvious explaining the sense of sight

    “When you’re thirsty nothing feels better than drinking liquid!”
    ~ Captain Obvious on Hydration

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  2. I’m glad NIDS is getting attention. I seem to recall reading about it when the atypicals were first introduced, and all the professionals were saying that NIDS and the dysphoria that comes from many neuroleptics were both a thing of the past. And now…

    …well, at least these doctors in Tokyo are talking about it. Maybe docs in the US will talk about it in 10, 15 years. Probably whenever Latuda goes off patent.

    I do find it interesting that one reason this is attracting attention, it seems, is because of neuroleptic use in Bipolar Disorder. I think the issue there is that people who are diagnosed with Bipolar I are often white, have more education, and are more affluent than those diagnosed with Schizophrenia. Not always, but..often. I think what it boils down to is that patients who are supposed to be high functioning are having problems from the meds, so docs are willing to admit…yes, its the meds (at least…they are in Tokyo). Schizophrenic/Schizoaffective patients…still don’t matter (we/they apparently still need our AbiliQuel, obviously).

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  3. Thank you Japanese doctors. Wake up US and all Western doctors!

    As I’ve been saying, ad nauseam, “neuroleptic-induced deficit syndrome (NIDS) … can resemble the negative symptoms associated with schizophrenia and psychosis, leading to misdiagnosis and ineffective treatments.”

    And increasing the neuroleptic, rather taking the person off it, can result in these symptoms:

    “memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures.”

    Which are the central symptoms of neuroleptic induced anticholinergic intoxication syndrome. But doctors can not distinguish these symptoms from the positive symptoms of “schizophrenia,” thus again “leading to misdiagnosis and ineffective treatments.”

    High doses, or combining any, of these drug classes, “antihistamines, antipsychotics, antidepressants, and antiparkinsonian drugs[3] as well as atropine, benztropine, datura, and scopolamine,” can result in anticholinergic toxidrome, which makes a person “mad as a hatter.”

    Today’s “bipolar” drug cocktail recommendations are a recipe for how to create anticholinergic toxidrome. Today’s “bipolar” recommendations need to be changed, psychiatric industry.

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  4. Originally, it was called “Iatrogenic Neuroleptic Pharmaceutical Cerebral Cognitive Impairment Malfunction”….
    By now, that “diagnostic label” is over 20 years old. It’s since been simplified to:
    IATROGENIC NEUROLEPSIS. Yes, it’s in my medical chart at Cheshire Medical Center, Dartmouth Hitchcock, Keene (“CMC/DHK”)….
    I KNOW those diagnostic labels are there. I put them there myself.
    But it was the psychs who drugged me who really created them….
    Iatrogenic neurolepsis. First, “schizophrenia”, next, that bogus “bi-polar disorder”.
    So-called “mentall illnesses” are exactly as real as presents from Santa Claus. But not more real. They have SUBJECTIVE reality, but NOT OBJECTIVE reality. Objective reality is often also known as “consensus reality”. And yes, “presents from Santa Claus” are VERY real. I got lots of them, as a kid.
    Psychiatry is nothing more than 21stCentury Phrenology with Pharma.
    21st Century Phrenology with DRUGS.
    We’re at a vital pivot-point in time. If we allow the EVIL of Pharma & the DSM to prevail, we’re lost.
    (c)2016, Tom Clancy, Jr., *NON-fiction
    (But, there are small victories happening every day. Here in Keene, N.H., quack shrink Dr. Marcia Pabo recently had a “sudden departure”, and CMC/DHK had to shutter it’s Child Psych unit, and the ADULT unit was also threatened. CMC/DHK can’t find enough “psychiatrists” That’s a GOOD thing.)
    And hopefully, the whole lie of “Community Mental Health Centers” will be exposed for the SCAM that it is. Psychiatry has done, and continues to do, far more harm than good.
    Please also feel free to write me at: P.O.Box 1860, Keene, N.H. 03431
    Yes, there ARE some decent psychs and psychologists. But they’re a dying breed. Thank GOD.
    (Yes, SOMEtimes, SOME people DO do better on SOME drugs for SOME short time…..

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  5. In my 50 year career as a psychotherapist I generally found that psychiatric drugs interfered with patients being able to discover the source of the trauma that led to their symptoms. I suppose that many years in science had taught me to look for underlying fundamentals when there was a problem to be solved.
    Psychiatrists seem to aim to relieve patients of their symptoms instead of following the symptoms to the source of the problem, and I did have patients who just wanted to have an instant cure.
    Frequently the patient knew of the trauma but had not connected it with their painful symptoms because of the time lapse, and also because no helping person had helped them make sense of their life and integrate themselves.
    The most psychotic patients I saw had missed out on normal human/mamallian nursing and it seemed that a lot of their angry self destructive behaviour was for their inner child that was screaming out for succour. They needed lengthy help and understanding, as well as, in a few cases a baby’s bottle.
    Fortunately in Ontario the health care system never questioned the length of the therapy and the patients were able to become healthy and to help other people.

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