Sunday, March 26, 2023

Global Survey Leads to New Recommendations for Deprescribing Psychiatric Drugs

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Growing rates of long-term psychiatric drug prescriptions and documented issues with withdrawal demonstrate a need for safe deprescribing practices.

Understanding the Neurobiology of Post-SSRI Sexual Dysfunction

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Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.

Antidepressants No Better Than Placebo for About 85% of People

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Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

Recovery Rate Six Times Higher For Those Who Stop Antipsychotics Within Two Years

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People with "serious mental illness" who stop taking antipsychotics are more likely to recover, even when accounting for baseline severity.

Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain

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A new study published in JAMA Psychiatry connects antipsychotics with damage to the brain in multiple areas.
Scowling teenage boy holding up pills sealed in blister packs in his hand as he leans on a wooden table with an intense stare

Risk of Depression Spikes When Kids Take Ritalin

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Risk of depression increased when children were taking methylphenidate for ADHD, but once they stopped taking the drug, depression risk dropped to normal levels.

Less Than a Quarter of Those with Depression Respond to Treatment in Real Life

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In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

Psychiatric Drugs Do Not Improve Disease or Reduce Mortality

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Nassir Ghaemi: “Most psychiatric medications are purely symptomatic, with no known or proven effect on the underlying disease. They are like 50 variations of aspirin, used for fever or headache, rather than drugs that treat the causes of fever or headache.”

New Guidance on Antidepressant Withdrawal for Doctors in the UK

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New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.
A boy is holding a head. He is unhappy and upset.

The Faulty Reasoning That Turned ADHD Into a Disease

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Leading ADHD researchers outline four mistakes that turned ADHD from a description of behavior into a medical disease.

ADHD Diagnosis Leads to Worse Quality of Life, Increased Self-Harm in Kids

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When comparing kids with the same symptoms who were either diagnosed with ADHD or not, those who received the diagnosis had worse outcomes.

Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues

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A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.
Illustration of a shape of a baby crawling made out of various types of pills, on a black background

Health Risks to Babies When Antidepressants Used During Pregnancy

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Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.

Involuntary Hospitalization Increases Risk of Suicide, Study Finds

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New study finds that people who felt they were coerced into being hospitalized were more likely to attempt suicide later.

Antipsychotics Increase Risk of Dementia; New Research Illuminates Why

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In JAMA psychiatry, researchers outline new theories connecting antipsychotic use in people with schizophrenia and increased dementia risk.

Gradual Tapering Recommended for Antidepressant Discontinuation

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A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.

Adults Treated for ADHD Report Low Quality of Life

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Adults receiving ADHD medications and therapy frequently experience adverse events that interfere with employment and daily life.

Therapy Beats Drugs for Depression for Long-Term Outcomes

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Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.

Stimulants Don’t Improve Academic Performance in Kids with ADHD

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“Efforts to improve learning in children with ADHD should focus on obtaining effective academic instruction rather than stimulant medication.”

Robin Williams On Antidepressant at Time of Suicide

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Robin Williams had "therapeutic" levels of the tetra-cyclic antidepressant mirtazapine in his blood at the time of his suicide, according to the coroner's report...

Antidepressants Blunt Ability to Feel Empathy

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A new study suggests that taking antidepressants impairs empathy, while the experience of depression itself does not.

Researchers Seek Standardized and Safe Antidepressant Tapering Protocol

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A new study promotes the use of a standardized approach to antidepressant tapering.

Antidepressants Do Not Prevent Suicides, May Increase Risk

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When the CDC released data revealing an increasing suicide rate in the US, some experts, speaking to major media outlets, speculated that the increase...
Vector-style illustration depicting men and women chained to a giant pill bottle

Researchers Identify Factors to Predict Risk of Antidepressant Withdrawal

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Paroxetine, SNRIs, and MAOIs were associated with the highest risk of withdrawal, as was long duration of use and whether the person experienced withdrawal in the past.

Animals Exposed to Antidepressants in Utero Are Worse at Taking Care of Their Own...

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A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.