Antidepressants

In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.

The jury in Anthony Orban's California trial for rape - which Orban argued was the result of a 'psychotic break' caused by his recent...

A retrospective study in the Journal of Clinical Psychiatry examined cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants.

Researchers interviewed people who were given medical advice to discontinue antidepressants.

Depressed pregnant women need good care.  They should not be made to feel guilty for the choices they make concerning their depression or lectured to by those who don’t understand the area or lack compassion for them.  In that sense, Andrew Solomon does the public a service by turning his attention and writing talents to the topic of depression and pregnancy this week in the New York Times.  However, a crucial part of providing good care to depressed pregnant women is to give them accurate information on the topic.  In this sense, Andrew Solomon falls short.

When I first saw this Lancet 2018 network meta-analysis of antidepressant trials, my thought was that the authors had rewarded those companies that had cheated the most with their trials. My suspicion was strengthened when I looked at the results in their abstract and the three drugs they claimed were more effective and better tolerated.

Researchers at Yale University found that stress in rats blocks the activity of a gene that promotes healthy neural connections in the brain. The...

The BMJ article on The Marketing of Serotonin has stirred some interest. There are some  highly technical comments on the BMJ site but of course the key point behind the piece is the rather obvious fact that twenty-five years ago many people were saying it was all a myth. The extraordinary Michael Leunig nailed it twenty years ago in the sketch above. (Leunig is wonderful across the board and razor sharp on medicine and mental health).

Bob Fiddamen dissects the issue of suicidality, bizarre behavior and antidepressants in light of BMJ Open's publication of "Suicide-related events in young people following...

Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.

On April 19, 2014, The Lancet published an article titled Do we underestimate the benefits of antiddepressants?, by German psychiatrists Mazda Adli and Ulrich Hegerl. The authors argue that randomized controlled trials (RCT's), as currently conducted, systematically underestimate the benefits of antidepressants and overestimate the benefits of psychotherapy. But what's interesting is that in all the years that pharma-psychiatry was churning out its fraudulent, spurious and self-serving "findings," I never heard of a single complaint from psychiatry about these kinds of methodological issues.

In a review of 68 articles published between 2005 and 2011, Israeli researchers found that most well-controlled studies failed to show a significant effect of...