MIA Articles about Psychiatric Drugs and Withdrawal

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

The Ethics of Antipsychotic Dose Reduction and Patient Rights

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New research highlights the ethical responsibilities of clinicians in supporting patients who choose to reduce or discontinue antipsychotic medication.

Antipsychotic Dose Reduction Linked To Long-term Improvements In First-Episode Schizophrenia Patients

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Careful reductions in dosage levels of antipsychotic medications over time improved long-term rates of recovery and functional remission in patients diagnosed with a first-episode psychosis.

Major Risks from Drug Interactions in Common Psychiatric Polypharmacy

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It is very common for psychiatric patients, especially those diagnosed with schizophrenia, to be prescribed two or more psychiatric medications at once, and this...

Study Shows Success With Reduced Antipsychotic Use

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People who reduced antipsychotic use by tapering were doing just as well after five years as those who continued using the drugs.

Increased Risk of Preterm Birth in Women Taking Antidepressants

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A detailed meta-analysis of the published research on women taking antidepressants during pregnancy finds that the rate of preterm birth is nearly doubled in the third...

Cold Turkey

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The other day I talked to a friend who I hadn’t seen for quite a while. She told me that she had been prescribed Seroquel for sleep problems about a year ago. But when she started to read about it a couple months ago she got really nervous that it was causing her long term health complications and she stopped taking it - cold turkey - without tapering. I wondered about our conversation afterwards and thought about the countless amount of people who don’t tolerate their psychiatric meds and quit cold turkey.

Online Experts on Withdrawal

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Online communities are stepping in to help people facing withdrawal effects amass information and receive support for their withdrawal experiences.

“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity

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Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.

New Study Examines Successful Discontinuation of Antipsychotics

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A new study to be published in the next issue of Schizophrenia Research examines patients suffering from a first-episode of psychosis who stop taking any antipsychotic drugs. The researchers attempt to identify variables that can serve as predictors of the successful discontinuation of antipsychotics. They find, for example, that those who discontinue the drugs have, on average, the same outcomes as those who stay on them, and that those who have better social integration are more likely to discontinue without relapse.

Listening to the Patient Voice: The Antidepressant Withdrawal Experience

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Patient advocates join with researchers and service users to present first-hand experiences of antidepressant withdrawal.

ďťżNew Rat Study: SSRIs Markedly Deplete Brain Serotonin

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Dutch investigators will soon publish an article in Neurochemistry International that sheds light on how SSRI antidepressants affect the serotonergic system over the longer...

David Cohen on Madness Radio: The Meaning of Medications

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David Cohen's work begins to address a paradox: medication effects are not simply chemical impacts on a biological brain, but rather the complex interactions of social factors, expectation, placebo, "nocebo," and learning. As a harm reduction approach to withdrawal emphasizes, empowerment may be the most important consideration for supporting people's wellness.

Researchers Provide Guidance for Reducing and Stopping Psychiatric Drugs

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New guidance on how to taper and discontinue from psychiatric drugs from leading researchers Mark Horowitz and David Taylor.

New Clinical Guidelines on Deprescribing Benzodiazepines

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New guidelines recommend deprescribing benzodiazepine receptor agonists for adults.

Study Finds Improved Functioning for ‘Schizophrenia’ Without Antipsychotics

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Long-term treatment with antipsychotic drugs is currently considered the standard treatment for patients diagnosed with ‘schizophrenia.’ A new study challenges this practice, however. The...

The Real Benzo Hysteria

On June 12th, Psychology Today published an article entitled, "Benzo Hysteria: the Chilling Effects of the 'Addictive' label," by Ed Shorter, PhD. A dangerous and unfounded claim was made in its final paragraph, which reads as follows: "The benzos are among the safest and most effective drug classes in the history of psychopharmacology." Benzodiazepines are in fact highly addictive and many people suffer for years from protracted withdrawal syndromes that are disabling.

Lack of Guidance Available for Discontinuing Psychiatric Drugs

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A new article discusses the lack of research dedicated to discontinuing psychiatric drugs and reviews existing strategies.

Antipsychotic Drug Associated with Potentially Fatal Skin Rash

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The US Food and Drug Administration is warning the public that the antipsychotic medication ziprasidone "is associated with a rare but serious skin reaction...

Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read

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A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.

Antidepressants Actually Reduce Serotonin Levels

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Common scientific beliefs about serotonin levels in depression and how antidepressants act on the brain appear to be completely backwards.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

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A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Different Antipsychotics Have Different Effects on Brain Volume

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First generation antipsychotics seem to cause general brain volume loss, while second generation antipsychotics seem to both increase and decrease the thickness of different parts of the brain.
Girl, looking confused, holding pill bottle

Official Guidelines on Antidepressant Discontinuation Fail Practitioners and Patients

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A review of clinical practice guidelines for antidepressant discontinuation from across the English-speaking world reveals major pitfalls.

Antidepressants and Preterm Birth: More Concerning Findings

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An important new research paper was published this week on the topic of antidepressant use during pregnancy and preterm birth.  The issue is a crucial one as preterm birth (i.e. birth at less than 37 weeks gestational age) is one of the most challenging problems facing the obstetrical community today.  Rates of preterm birth have been increasing over the past two decades.  Babies born early have increased risks of morbidity and mortality.  At the same time, rates of antidepressant use during pregnancy have increased dramatically.