Genetics

The huge impact of the MISTRA, in addition to the harmful and regressive social and political policy implications that flow from it, necessitates a detailed analysis of the “science” behind the study’s major claims and conclusions. Here I offer a new critique of this famous and influential “separated twin study.”

The conventional Western classification systems of health conditions are based on flawed science shaped by reductionist, hierarchical, and profit-driven ideologies. THEN wants to create a new paradigm built upon principles drawn from systems science, the life course perspective, developmental neurobiology, and other evidence-informed studies.

The story of the Genain quadruplets has long been cited as evidence proving something about the supposed hereditary nature of schizophrenia. But who wouldn’t fall apart after surviving a childhood like theirs? The doctors attributed their problems to menstrual difficulties or excessive masturbation — anything except abuse.

As most readers are aware, it is widely believed that both within and without of psychiatry genetic factors play an important role in causing major psychiatric disorders such as schizophrenia, bipolar disorder, major depression, ADHD, autism, anxiety, and even post-traumatic stress disorder (PTSD). Twin studies provide the main pillar of support for this belief which is often, though mistakenly, presented as a scientific fact.

Autism is now simply assumed to represent a real, tangible, identifiable ‘thing.’ But no one is asking the obvious question: On what evidential basis can you conclude that autism represents a natural category that can be differentiated from other natural categories? According to the real science, autism should be seen as a fact of culture, not a fact of nature.

Twin studies supply the most frequently cited evidence in favor of important genetic influences on human behavioral differences. In an extremely small yet influential handful of studies, twin pairs were said to have been reared apart in different families. Twin researchers and others view this occurrence as the ultimate test of the relative influences of nature (genes) and nurture (environment). According to this view all behavioral resemblance between reared-apart MZ twin pairs (known as “MZA” pairs) must be the result of their 100% genetic similarity, because such pairs share no environmental similarity. But, far from being separated at birth and reared apart in randomly selected homes representing the full range of potential behavior-influencing environments, and meeting each other for the first time when studied, most MZA pairs were only partially reared apart, and grew up in similar cultural and socioeconomic environments at the same time.

While a great deal of the excitement about advances in psychological treatments comes from the potential for research in neuroscience to unlock the secrets of the brain, many mental health experts would like to temper this enthusiasm. A special issue of the Behavior Therapist released this month calls into question the predominant conception of mental illnesses as brain disorders.

As the schizophrenia/psychosis recovery research continues to emerge, we discover increasing evidence that psychosis is not caused by a disease of the brain, but...

The latest issue of the journal Behavioral and Brain Sciences features several prominent researchers arguing that mental health concerns are not “brain disorders.”

A new study analyzing over 21,000 participants found that differences in activation of brain regions in different psychological “disorders” may have been overestimated, and confirms that there is still no brain scan capable of diagnosing a mental health concern.

In recent months, two teams of researchers in the UK and the US published complementary findings about the epigenetic origins of schizophrenia that have scientific communities who indulge in ‘genetic conspiracy theories’ abuzz. While these results are intriguing, and no doubt involve pathbreaking research methodologies, this line of thought represents a decontextualized understanding both of the symptoms that are typically associated with schizophrenia, and their causes.

An increase in suicidal thoughts is a known and serious side-effect for various types of antidepressants. Recent studies suggest that there may be some...

Neuroscience researchers find no differences in brain connectivity between children with diagnoses of autism, ADHD, and those with no diagnoses.

Amid calls for a retraction, Lancet Psychiatry publishes articles criticizing the original finding and a response from the authors.

Structural competency in psychiatry emphasizes the social factors shaping patient presentations and encourages physician advocacy.

Human behavioral genetics and its allied field of psychiatric genetics are in trouble, as unfulfilled gene discovery expectations during the “euphoria of the 1980s” have continued to the present day, leading to researchers’ “nonreplication curse” dysphoria of the 2010s. In my recent book The Trouble with Twin Studies: A Reassessment of Twin Research in the Social and Behavioral Sciences, I presented a detailed argument that genetic interpretations of the common “classical twin method” finding that reared-together MZ twin pairs resemble each other more (correlate higher) for behavioral characteristics than do reared-together same-sex DZ twin pairs are invalid because, among other reasons, the twin method’s crucial MZ-DZ “equal environment assumption” (EEA) is false.

In this article I will attempt to debunk one of the great “scientific” smoke and mirrors shows of the past half century—the claim that stories of reunited separated MZ (monozygotic, identical) twin pairs indicate that heredity plays a major role in causing human behavioral differences. These stories, which are often used to sell the false ideology of genetic determinism, have entered the public imagination in a way that academic research results never could. Here I will show that these stories provide no evidence whatsoever that (as yet undiscovered) “genes for behavior” influence human behavioral development.

Psychiatric molecular genetic research has failed to discover genes that underlie the major psychiatric disorders, the existence of which twin and adoption studies are assumed to have established. "Genome-wide complex trait analysis" (GCTA) was developed a few years ago as a means of solving what researchers call the "missing heritability" problem. One researcher believed that the new GCTA method would “drive a stake through the heart of” criticism of behavioral genetic theories and methods, and would finally put criticism of twin studies “to rest.” The opposite scenario appears to be playing out, however, as leading behavioral genetic and psychiatric genetic researchers struggle to prevent some recent negative GCTA findings and the obvious false assumptions underlying twin research from driving a stake through the heart of twin studies themselves.

In a 1992 essay, British psychiatric genetic researcher Michael Owen wondered whether schizophrenia molecular genetic research would become the “graveyard of molecular geneticists.”1 Owen predicted that if major schizophrenia genes existed, they would be found within five years of that date. He was optimistic, believing that “talk of graveyards is premature.”2 Owen now believes that genes for schizophrenia and other disorders have been found, and was subsequently knighted for his work. Despite massively improved technology, however, decades of molecular genetic gene finding attempts have failed to provide consistently replicated evidence of specific genes that play a role in causing the major psychiatric disorders.

A conversation with Dr. Kelly Brogan, a leading voice in natural approaches to women’s mental health. With degrees from MIT and Weil Cornell Medical College, triple board certification in psychiatry, psychosomatic medicine and integrative holistic medicine, Dr. Brogan is uniquely qualified to challenge the pseudoscience of the chemical imbalance theory and the drug regimens that it spawned.

Derek Summerfield, consultant psychiatrist at South London and Maudsley National Health Service Foundation Trust, challenges the assumption that Western depression is a universal condition.

“What do you think caused your problems?,” I asked. “I have a chemical imbalance, a chemical imbalance, an imbalance in the brain that makes me ill.”

In the light of the much trumpeted claims that recent research has identified genes for schizophrenia, it is important to review the track record of this type of endeavor. Despite thousands of studies costing millions of dollars, and endless predictions that the genetics of schizophrenia would shortly be revealed, the field has so far failed to identify any genes that substantially increase the risk of developing schizophrenia.

Two generations of molecular genetic researchers have attempted, yet failed, to discover the genes that they believe underlie the major psychiatric disorders. The most recent failure is a molecular genetic study that was unable to find genes for symptoms of depression. Like most genetic researchers in psychiatry, the authors failed to consider the possibility that no such genes exist.

“Overall, this study showed that the information and awareness campaign had almost no significant effects on the general public's attitudes toward people affected by either schizophrenia or depression,” the researchers, led by German medical sociologist Anna Makowski, wrote. “One could assume that deeply rooted convictions cannot be modified by rather time-limited and general activities targeted at the public.”