Friday, May 29, 2020

New Antidepressant Shows Little Benefit, Significant Risks

Patient Drug News advises avoiding use of the antidepressant Vortioxetine (also called Brintellix or Trintellix), because the most recent evidence from the FDA shows...

PTSD and Antidepressants Linked to Diabetes

A JAMA Psychiatry study found links between PTSD, type 2 diabetes, and antidepressants.

Stopping SSRI Antidepressants Can Cause Long, Intense Withdrawal Problems

In the first systematic review of withdrawal problems that patients experience when trying to get off SSRI antidepressant medications, researchers found that withdrawing from SSRIs was comparable to trying to quit addictive benzodiazepines.

Semen Abnormalities Associated with SSRI Antidepressants

The French non-profit organization Prescrire has produced a special report about the impacts of SSRI antidepressants on male fertility.

Thoughtful Insight, Not Lack of It, Drives Some Patients to Quit Psychiatric Medications

Rather than a "lack of insight," it is actually a thoughtful weighing of complex risks and benefits that ultimately drives some people diagnosed with bipolar disorder to eschew psychiatric medications, according to a qualitative study in the Journal of Affective Disorders. And these people often develop sophisticated strategies in their efforts to manage without medications.

STOP or GO? Tapering Pregnant Women off of Antidepressants

A team in the Netherlands is currently investigating the effects of tapering off of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) during pregnancy....

Cognitive Function Improved by Reducing Antipsychotics

A 28-week randomized controlled study by researchers in Japan, Canada and the United States finds that a 50% reduction of risperidone or olanzapine significantly...

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off Antidepressants

Researchers interviewed people who were given medical advice to discontinue antidepressants.

More Evidence Antidepressants Might Induce Sexual Dysfunction Even After Stopping Them

A retrospective study in the Journal of Clinical Psychiatry examined cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants.

New Form of Mice Experiment Reveals Antidepressant’s Dangers Earlier

Scientists from the University of Utah say they have discovered a new way of doing mice experiments that more sensitively and quickly reveals negative...

Antipsychotic-induced Sexual Dysfunction Underreported

Researchers found some antipsychotics to be worse than others for causing sexual dysfunction.

Replacing Pain with Pain: Hazards of Antidepressant Use for Chronic Pain Relief

The paradox of relieving chronic pain with an antidepressant (and a new set of symptoms).

Prenatal Antidepressant Exposure Raises Risk to Newborn of Pulmonary Hypertension

Researchers from Canada find the risk of persistent pulmonary hypertension of the newborn is increased for infants exposed to SSRIs in late pregnancy. Results...

Psychiatrists Argue For More Attention to Iatrogenic Harms

Psychiatrists argue that current practice fails to account for the interaction of biological, psychosocial and iatrogenic factors.

Children on Antipsychotics 50% More Likely to Develop Diabetes

Antipsychotic drugs increased the risk of children developing diabetes by 50%, and with an antidepressant added, their risk doubled.

Researcher: 60,000 Americans Now Taking Antipsychotics Will Die Prematurely

-A fired government health economist says that his research was showing that 60,000 Americans now taking antipsychotic medications will die prematurely.

Antipsychotics During Pregnancy Linked to Infant Problems

“Live, healthy babies are the most common outcome following the use of antipsychotic medication in pregnancy,” conclude Australian researchers in a study that was...

No Good Evidence That Antidepressants Prevent Relapse

Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Psychological Interventions Can Help When Tapering Off Antidepressants

Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Common Benzodiazepine Sedatives May Induce Aggression

Benzodiazepine medications that are commonly used for calming or sedating people can sometimes apparently cause violent or aggressive responses in some people, according to...

Pfizer Sued Over Zoloft’s Failure to Beat Placebo

A lawsuit filed Wednesday in San Jose, California seeks federal approval for two class-action lawsuits representing all U.S. users of the antidepressant Zoloft, accusing...

Alarming Report on Antidepressant Side Effects

Drawing on analysis of data from websites such as Paxilprogress.org, ehealthforum.com, depression forums.org, about.com, medhelp.org, drugLib.com, topic.com and survivingantidepressants.org, researchers from the University of...

Waking Blackouts On Sleep Drugs Can Lead to Dangerous Mishaps

In her blog on USC Annenberg's Reporting on Health, journalist Martha Rosenberg reviews some of the quantitative evidence and qualitatively bizarre anecdotal evidence of...

Evidence Lacking for Antidepressant Safety in Nursing Mothers

A scientific review says we need to know much more about the risks of nursing mothers taking SSRIs.

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