Sunday, March 24, 2019

MIA News Archives

Peer-Support Groups Were Right, Guidelines Were Wrong: Dr. Mark Horowitz on Tapering Off Antidepressants

In an interview with MIA, Dr. Horowitz discusses his recent article on why tapering off antidepressants can take months or even years.

Very Slow Tapering Best For Antidepressant Withdrawal

A new article in Lancet Psychiatry finds that slower tapering of SSRIs is better for preventing antidepressant withdrawal effects.

Psychological Interventions Can Help When Tapering Off Antidepressants

Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

Stopping SSRI Antidepressants Can Cause Long, Intense Withdrawal Problems

In the first systematic review of withdrawal problems that patients experience when trying to get off SSRI antidepressant medications, researchers found that withdrawing from SSRIs was comparable to trying to quit addictive benzodiazepines.

Gradual Tapering is Most Successful for Withdrawal from Antipsychotics

Mixed-Methods study explores the experiences of antipsychotic discontinuation among service users.

Study Finds Improved Functioning for ‘Schizophrenia’ Without Antipsychotics

Long-term treatment with antipsychotic drugs is currently considered the standard treatment for patients diagnosed with ‘schizophrenia.’ A new study challenges this practice, however. The...

Lithium May Cause Sexual Dysfunction — More Research Needed

Lithium appears to reduce libido and sexual function, and more research into the problem is needed.

Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting

Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.

Long-term Use of Lithium Can Cause Kidney Failure

A third of patients who have taken the common psychiatric medication lithium for over ten years have developed "chronic renal failure" from the drug.

SNRIs Added to the List of Drugs with Potential Withdrawal Symptoms

New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.

Danish Study Finds Better 10-year Outcomes in Patients Off Antipsychotics

Study finds that 74% of patients with a psychotic disorder off antipsychotics at end of 10 years are in remission.

New Clinical Guidelines on Deprescribing Benzodiazepines

New guidelines recommend deprescribing benzodiazepine receptor agonists for adults.

New Study Examines User Experience of Discontinuing Psychiatric Medications

Researchers find that support and self-care were helpful for users during discontinuation, but that mental health professionals were not very helpful.

New Study Explores Approaches to Discontinuing Antidepressants

Psychiatrist and psychologist outline pharmacological and psychotherapeutic strategies for discontinuing antidepressants.

Antipsychotic Medications Are Causing Obsessive Compulsive Disorders

Common second-generation antipsychotic medications are causing symptoms of obsessive-compulsive disorder to emerge in many people who previously only had schizophrenia symptoms, according to a...

New Research on Patient-Centered Deprescribing for Antipsychotics

Researchers review the risks and benefits of deprescribing from antipsychotic drugs and advocate for a patient-centered approach to tapering.

“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity

Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.

Antipsychotic-induced Sexual Dysfunction Underreported

Researchers found some antipsychotics to be worse than others for causing sexual dysfunction.

Prescribing Benzodiazepines As-Needed Leads to Abuse

A new study reported on in Medscape, examined risk factors for misuse of benzodiazepines (drugs such as Xanax, Ativan, and Klonopin). The researchers found that patients who had been prescribed the medication on an as-needed basis were more likely to end up abusing it than those who had been prescribed a standing dose.

Autism, Antidepressants, and Pregnancy: The Basics

This month, the seventh study and eighth study came out on the topic of antidepressant exposure during pregnancy and autism.  And these studies showed, as essentially all of the others have, that antidepressant use during pregnancy (principally with selective serotonin reuptake inhibitors or SSRIs) is associated with autism in the exposed children. With so many children being diagnosed with autism and so many women taking antidepressants during pregnancy, everyone wants to know: are these things (the antidepressants) associated with autism or not?  Quite frankly no one has the time to read through all eight scientific papers (and dozens more animal and basic science studies) to understand this important area, so I will do my best to briefly summarize it here.

Study Shows Success With Reduced Antipsychotic Use

People who reduced antipsychotic use by tapering were doing just as well after five years as those who continued using the drugs.

Antidepressants Actually Reduce Serotonin Levels

Common scientific beliefs about serotonin levels in depression and how antidepressants act on the brain appear to be completely backwards.

New Antidepressant Shows Little Benefit, Significant Risks

Patient Drug News advises avoiding use of the antidepressant Vortioxetine (also called Brintellix or Trintellix), because the most recent evidence from the FDA shows...

Different Antipsychotics Have Different Effects on Brain Volume

First generation antipsychotics seem to cause general brain volume loss, while second generation antipsychotics seem to both increase and decrease the thickness of different parts of the brain.

Antidepressant Use Climbs as Patients Find it Difficult to Discontinue

Findings point to the role of withdrawal symptoms and prescriber practices in long-term antidepressant use.

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