Researchers Document Protracted Withdrawal from Antidepressants

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Protracted Withdrawal Syndrome characterized by long-term adverse experiences after coming off of antidepressants.

Prescribing Benzodiazepines As-Needed Leads to Abuse

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A new study reported on in Medscape, examined risk factors for misuse of benzodiazepines (drugs such as Xanax, Ativan, and Klonopin). The researchers found that patients who had been prescribed the medication on an as-needed basis were more likely to end up abusing it than those who had been prescribed a standing dose.

Prescribers Often Fail to Support Patients Discontinuing Antidepressants, Study Finds

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Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Peer-Support Groups Were Right, Guidelines Were Wrong: Dr. Mark Horowitz on Tapering Off Antidepressants

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In an interview with MIA, Dr. Horowitz discusses his recent article on why tapering off antidepressants can take months or even years.

Antidepressants Actually Reduce Serotonin Levels

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Common scientific beliefs about serotonin levels in depression and how antidepressants act on the brain appear to be completely backwards.

Antidepressant Withdrawal Linked to Suicide Attempt in Case Study

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Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.

Differentiation of SSRI and Benzo Dependence/Withdrawal “Not Rational”

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Researchers from the Cochrane Center and University of Copenhagen in Denmark, publishing in the May issue of Addiction, "explore the rationale for claiming that...

Researchers Seek Standardized and Safe Antidepressant Tapering Protocol

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A new study promotes the use of a standardized approach to antidepressant tapering.

Very Slow Tapering Best For Antidepressant Withdrawal

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A new article in Lancet Psychiatry finds that slower tapering of SSRIs is better for preventing antidepressant withdrawal effects.

Prenatal Exposure to SSRIs Significantly Increases Autism & Developmental Delays

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Research on 966 mother-child pairs from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study finds that prenatal SSRI exposure was nearly 3...

Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse

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A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.

Benzos Fail to Prevent, May Increase PTSD

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In a review of the evidence regarding benzodiazepines, researchers from the University of Michigan find that benzodiazepines used in the treatment of PTSD are...

2X Risk of Postpartum Hemorrhage Antidepressants

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A study of 106,000 pregnant women with a diagnosis of mood or anxiety disorder, by researchers from Harvard, Duke, Michigan State and the university...

Semen Abnormalities Associated with SSRI Antidepressants

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The French non-profit organization Prescrire has produced a special report about the impacts of SSRI antidepressants on male fertility.

Antipsychotic Medications Are Causing Obsessive Compulsive Disorders

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Common second-generation antipsychotic medications are causing symptoms of obsessive-compulsive disorder to emerge in many people who previously only had schizophrenia symptoms, according to a...

STOP or GO? Tapering Pregnant Women off of Antidepressants

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A team in the Netherlands is currently investigating the effects of tapering off of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) during pregnancy....

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressants Seem to Increase Heart Disease in the Elderly

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Depressed elderly people are more likely to suffer heart disease not because of their depression, but apparently due to antidepressant drugs.

Increased Risk of Preterm Birth in Women Taking Antidepressants

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A detailed meta-analysis of the published research on women taking antidepressants during pregnancy finds that the rate of preterm birth is nearly doubled in the third...

Prenatal Antidepressant Exposure Raises Risk to Newborn of Pulmonary Hypertension

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Researchers from Canada find the risk of persistent pulmonary hypertension of the newborn is increased for infants exposed to SSRIs in late pregnancy. Results...

Study Finds Improved Functioning for ‘Schizophrenia’ Without Antipsychotics

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Long-term treatment with antipsychotic drugs is currently considered the standard treatment for patients diagnosed with ‘schizophrenia.’ A new study challenges this practice, however. The...

New Antidepressant Shows Little Benefit, Significant Risks

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Patient Drug News advises avoiding use of the antidepressant Vortioxetine (also called Brintellix or Trintellix), because the most recent evidence from the FDA shows...

New Research on Patient-Centered Deprescribing for Antipsychotics

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Researchers review the risks and benefits of deprescribing from antipsychotic drugs and advocate for a patient-centered approach to tapering.

No Good Evidence That Antidepressants Prevent Relapse

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Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.
Picture of distressed man facing pills

What Helps Long-Term Users of Benzodiazepines and Z-Drugs Discontinue?

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Current long-term users of benzodiazepines and Z-drugs identify barriers and facilitators for discontinuation.