Friday, February 3, 2023

Tag: RCTs

Jim van Os and Peter Groot: When Assessing Antidepressant Withdrawal Methods,...

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Jim van Os and Peter Groot discuss their paper: “Successful Use of Tapering Strips for Hyperbolic Reduction of Antidepressant Dose: A Cohort Study” published in the journal Therapeutic Advances in Psychopharmacology.

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

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A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

Researcher Critiques Misleading Media Coverage of Lancet Antidepressant Meta-Analysis

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The BMJ’s clinical editor takes issue with uncritical media coverage of antidepressant network meta-analysis, outlining reporting missteps.

Randomized Controlled Trials of Psychiatric Drugs Tell of Harm Done

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The most important data in an RCT is not whether the drug provides a statistically significant benefit over placebo. The most important data is the “number needed to treat” calculation (NNT). For the person considering taking an antidepressant or an antipsychotic, the NNT data provides the “math” needed to weigh the potential benefit of taking the drug against the potential harm of doing so.

Review of Pediatric Antidepressant Studies Finds Evidence of Benefit Lacking

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Review of pediatric antidepressant studies finds the vast majority are negative on primary outcomes and an increased risk for suicidality.

The Algorithm Will See You Now: A Geek Tragedy

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We would, in fact, save vast amounts of money by giving the pharmaceutical companies ten times the inflated prices they currently receive for drugs as part of a bargain that ensures only 10% of those currently taking lipid-lowering drugs, antidepressants, biphosphonate and other drugs end up on them. The savings would come from not having to treat treatment-induced disabilities.

Study 329: Big Risk

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Study 329 seems to fit the classic picture: It has Big Pharma ghostwriting articles, hiding data, corrupting the scientific process and leaving a trail of death, disability and grieving relatives in its wake. But is it at fault alone? Both Big Pharma and Big Risk (the insurance industry) were once our allies in keeping our hopes alive – in keeping our children alive and well. They are now a threat. And of the two – Big Risk is the bigger threat.

NIMH Funding Changes Threaten Psychotherapy Research

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The National Institute of Mental Health (NIMH) is increasingly shifting its research emphasis toward attempting to uncover biomarkers for “mental diseases,” which may have dramatic consequences for research and training in clinical psychology. In an article to be published in next month’s Professional Psychology: Research and Practice, Marvin Goldfried outlines how the shift in funding priorities for psychological research is tied to the needs of pharmaceutical companies and the biological model in psychiatry.