A new study published this month in the journal Neuron identifies the mechanism by which antipsychotic drugs can induce parkinsonism, a condition involving movement abnormalities. The researchers found that antipsychotics block D2 dopamine receptors in a part of the brain called the striatum, specifically acting on interneurons in this area, leading to problems with movement.
Kharkwal, G., Brami-Cherrier, K., Lizardi-Ortiz, J.E., Nelson, A.B., Ramos, M., Del Barrio, D., Sulzer, D., Kreitzer, A.C. and Borrelli, E., 2016. Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons. Neuron, 91(1), pp.67-78.