My Response to the FDA’s ECT Rule Change

Christopher James Dubey
By
-
26
842

My Comment on Docket No. FDA–2014–N–1210, about the FDA’s Proposed Order to Reclassify the ECT Device for Treatment-Resistant Depression

In December 2015, the FDA issued “a proposed administrative order to reclassify the electroconvulsive therapy (ECT) device for use in treating severe major depressive episode (MDE) associated with major depressive disorder (MDD) or bipolar disorder (BPD) in patients 18 years of age and older who are treatment-resistant or who require a rapid response due to the severity of their psychiatric or medical condition, which is a preamendment class III device, into class II (special controls) based on new information.”

On March 27, I submitted my comment on that proposed rule to the Federal Register’s Docket No. FDA–2014–N–1210. On April 4, I received an email message from an FDA representative stating, “We have received your comment. Comments do not always post immediately, and if your comment contained information that appears private or confidential, it may not be posted publically.”

The following is an excerpt from the comment I submitted, which was not posted on the docket.

***

I lived through forced ECT from 2005-2006 at the Institute of Living in Hartford, Connecticut. My experience with ECT was the impetus for me to become involved in the antipsychiatry and Mad Pride movements, although I am not entirely opposed to voluntary mental health treatment. Below are links to articles I have written about my experience and summaries of several references of the harms caused by ECT.

 

I take issue with the psychiatric term “treatment-resistant depression” (TRD). There seems to be some ambiguity about an exact definition for this term, although one article states: “While there is an absence of formal diagnostic criteria, proposed features of TRD have evolved over time, with broad agreement that TRD is characterized by (i) the syndrome of unipolar depression; (ii) the failure of antidepressant medication, which has been defined either categorically, for instance the failure of at least two antidepressants from different pharmacological classes, or according to increasing levels of resistance; (iii) each antidepressant medication trial being adequate in terms of dose; duration; compliance and tolerability; and (iv) the absence of physical illness or psychosocial dysfunction, which should be the primary focus of treatment” (Wijeratne & Sachdev, 2008, page 752).

Defining TRD as the failure of two antidepressants involves some assumptions, such as that antidepressants should be effective for every patient in clinical depression and that they are the only appropriate and effective first-line treatments for it.

The FDA should also consider whether the psychiatric definition of the term “treatment-resistant depression” would hold up under scrutiny in a court of law, such as in the possibility of an involuntary patient diagnosed with TRD filing a lawsuit against their psychiatric prescriber over whether the term is valid. Even if one only considers traditional psychiatric antidepressants, there are other classes of drugs that can be used and an array of differing talk therapies. Doctors may have referred to me as treatment-resistant during my first two hospitalizations, after having been given first paroxetine and then citalopram long-term. Neither helped me much, and now there is more scientific evidence that paroxetine can contribute to suicidal ideation and behavior (Le Noury et al., 2015). [Note: I was not on multiple SSRIs at the same time. I was on paroxetine first in 2005, withdrew from it, had some breakdowns likely contributed to by the withdrawal, and was later prescribed citalopram.]

Although I was twenty-two during my first serious suicide attempts, I consider myself to have been not that far in mental maturity from adolescence, an age group in which there is now agreement that paroxetine has an increased chance of worsening suicidal feelings. My depression has never been a melancholic or listless depression, but an agitated, angry, and impulsive. [It’s possible this was partly drug-induced akathisia, but I remember having the anger and agitation issues before taking any antidepressants. My impulsivity may have worsened after being on a SSRI, though.] I also now believe I have traits of borderline personality disorder. The point has been made before by others that the nature of depression differs between individuals (as the diagnosis of MDD is not carried out using a valid biomarker) and, therefore, treating depression often involves individual trial and error with medications or other types of mental health treatment.

Dialectical behavior therapy (DBT) was introduced to me after my second suicidal hospitalization. However, it was offered to me only after my forced ECT and in a rather casual manner, as if it were a secondary treatment. At that point, having experienced the trauma of forced ECT, which only increased my antagonism to the medical professionals treating me, I had little interest in working on DBT or any other treatment they offered. It wasn’t until a few years later during a partial hospitalization program through a different institution that specialized in DBT that I began to take this type of therapy seriously and benefited from the parts that I found helpful.

Docket No. FDA–2014–N–1210 admits that some patients may experience the side effects of worsening psychiatric symptoms due to ECT’s ineffectiveness (page 81227), but it also shows a lack of acknowledgment of how ECT can directly or indirectly cause a worsening of psychiatric symptoms. Not only can ECT cause side effects of memory loss and cognitive impairment, but many people have reported that these side effects contribute to their psychological or emotional distress. In addition, many have reported distress upon undergoing the procedure of ECT, followed by posttraumatic memories, flashbacks, and nightmares about the procedure, particularly if it was involuntary.

While there have been many studies on ECT, some aspects of the treatment have had little scientific study but are evidenced by many subjective patient accounts–emotional trauma caused by ECT is one such aspect.

I take issue with assumptions that ECT has little risk of death, aside from the general risks of anesthesia. An article in The West Australian reports that involuntary psychiatric patient Stephen Robson died March 28, 2012, less than an hour after receiving ECT at the Alma Street clinic in Fremantle (Pownall, 2015). The article is unclear about the exact manner of death but indicates that he jumped off the building, saying, “CCTV footage showed Mr. Robson entering a lift and traveling to the fifth floor. He walked through entry/exit doors as a medical student entered using her swipe card. Minutes later, Mr. Robson was fatally injured on Hampton Road.” While I understand that it is speculative of me to believe that this man committed suicide because forced ECT exacerbated his distress past the tipping point, it is equally speculative to assume ECT did not contribute to him committing suicide. Even his physicians may not have recorded his true feelings about the treatment in his medical records, as I know my medical records did not record most of my feelings about my ECT during my hospitalization. There were even misleading statements written in my medical records.

In another recent case of death shortly after ECT, 71-year-old Elsie Tindle went into a permanent epileptic seizure after her ECT this year and the autopsy concluded she suffered irreparable brain damage (Prince, 2016). She was an involuntary patient at a hospital in Sunderland, United Kingdom.

As I stated previously, some aspects of ECT have had little or no scientific study and these questions deserve to be researched just as other issues of the treatment have.

Are there differences in outcomes and attitudes between patients given voluntary ECT and those forced to undergo involuntary ECT?

While the possibility of the placebo effect in ECT has been studied at least a fair amount, I am unaware of any research on the real possibility of nocebo effect in ECT, particularly in involuntary ECT.

Are patients who experience adverse effects less likely to report their experiences or feelings to their mental health professionals? Are they reporting such feelings to other parties instead?

Do the attitudes of medical professionals color their own interpretations of whether the treatment was effective for their patients? Have studies been looking at whether the interpretations of medical professionals about the outcomes of ECT differ from the interpretations of the patients or friends and family?

I have heard and read many firsthand and secondhand accounts of people who had ECT whose subsequent cognitive problems made it much more difficult for them to return to work. Some people have said they lost skills that were key to their employment, such as being able to read music.

I believe I have some cognitive impairment that negatively affects my social functioning, the speed at which I can learn, and my ability to remember information. Just because my cognitive reserve is high enough to manage these symptoms – for the most part – it is not proof of their non-existence. I’m unsure of whether the impairment is due to my injuries, depression, medication, or ECT, but I believe ECT is a major contributing factor.

Authors Note: I am not endorsing any medication, screening for mental disorders, or the idea that fuzzy diagnoses such as bipolar disorder are accurate. But I still take a SSRI, a mood stabilizer, and some other medication. I’m a regular reader of MIA, and I’m aware of the risks of the medications I take. I honestly wish I had never been referred to a psychiatrist as a teenager and that I had never agreed to start taking prescription psychiatric medication, especially a SSRI. I have tried to withdraw from prescription medications several times, but I feel that they’ve permanently changed my biology in ways that make it almost impossible to withdraw from them now. For instance, I can no longer get to sleep without quetiapine, even though I’ve tried tapering and OTC alternatives.

References

Author: Food and Drug Administration. Article: 21 CFR Part 882 [Docket No. FDA–2014–N–1210]. Periodical: Federal Register. Volume: 80. Issue: 249. Date: December 29, 2015. Pages: 81223- 81233.

Authors: Joanna Le Noury, John M Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru, Elia Abi-Jaoude. Article: Restoring Study 329: Efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. Periodical: BMJ. Volume: 351. Date: 2015. Pages: 1-16.

Author: Angela Pownall. Article: Clinic ‘security issues’ before death. Newspaper: The West Australian. Date: May 1, 2015.

Author: Daniel Prince. Article: Electric shock therapy death: Sunderland coroner writes to Health Secretary in bid to prevent further fatalities. Newspaper: Sunderland Echo. Date: March 11, 2016.

Authors: Chanaka Wijeratne, Perminder Sachdev. Article: Treatment-resistant depression: critique of current approaches. Periodical: Australian and New Zealand Journal of Psychiatry. Volume: 42. Issue: 9. Date: 2008. Pages: 751-762.

RELATED ARTICLESMORE FROM AUTHOR

26 COMMENTS

  1. Alas, the psychiatric profession doesn’t see things that way. Through a patients’ group, I met a gent, who’d been a hospital’s somatic therapy guy in the most heavily populated region of my state and, having a heavy interest in Clinical Ecology, was looking for a hospital in a rural region where he could supervise Randolph fasts and subsequent food allergy challenges. After accepting his offer to practice there, a local hospital changed its mind, telling him they thought that the fasting might be too dangerous. Did the hospital think they were just getting a new somatic therapy guy and panicked when they found out what he was going to do? I leave it for the ECT patients to decide whether they’d be more comfortable and feel safer getting a series of ECT, than they would fasting for 4-7 days on water, and taking a series of food tests, should they become symptom-free after the fast..

  2. There is something particularly heinous to me about “treatment-resistant depression.” First off, “depression” can’t resist anything. Second, “treatment” is very narrowly defined as drugs. Third, and I think most importantly, failure to help someone with one’s standard approach does NOT mean that the subject is “resistant.” It means your treatment DID NOT WORK! These should be regarded as “treatment failures,” but somehow the recipient, nay, not even the recipient is so empowered, the DEPRESSION resisted and refused to respond to the treatment as expected! That dastardly “disease” is responsible for our product not working – it can’t be that we are just doing the wrong thing!

    What would you think of a garage mechanic who said that your engine failed to work because it had “repair-resistant fuel injectors,” but to come back once a month for a three-hundred dollar “treatment” to minimize the “symptoms?” I think you’d look for a new mechanic.

    What’s wrong with just admitting that your plan didn’t work?

    —- Steve

      • I used to work on a crisis line, and talked once to a woman who had been trying different antidepressants for over a year at the behest of her various physicians/psychiatrists. She was absolutely frantic and becoming convinced that there was something desperately wrong with her that she would not respond to this ‘treatment’ despite her doctors having ‘tried everything.’

        I asked her, “Has anyone told you that there are other things you can do about depression besides antidepressants?”

        Suddenly calm. “No…”

        “Well there are.”

        “Oh. Well, that’s good…”

        And of course, she was completely open to trying out a range of suggested remedies that we were able to come up with in a 5-10 minute further conversation, and felt MUCH better by the end, if only because she’d been given some sense that SHE could do something about it instead of waiting and hoping that the “experts” would come up with a magical cure.

        Seriously. An entire year had gone by “trying everything,” and no one had so much as mentioned there might be something else she could do besides trying different drugs. Idiocy, but it masquerades as “treatment-resistant depression.” Sets my teeth on edge every time I hear of it! And they wonder why there is “stigma” attached to “mental illness.” They cause it themselves by blaming the patient for their own failure to help!

        —- Steve

        • And of course, this woman was incredibly lucky in that she called you and that she was not electro shocked after meeting the minimal standard for a label of “treatment resistance”- (her lol) “failure” to “respond” to TWO “adequate” trials of antidepressant drugs (yes, the ones little better than placebo that also increase agitation, anxiety, depression, suicidal thought…). Let’s see- what time frame would that be? Well, 6 weeks per drug, so 12 weeks, and perhaps a 2 week taper or not? Just switch to next? So, frighteningly, after as little as THREE months a lunatic psychiatrist could be “meeting an ‘acceptable’ standard of ‘care'” by signing her up for brain boiling/damaging ECT.
          What is wrong with this picture? Lots, but the scariest is that ECT is there, waiting to decimate another life. And because of pro- shock “doctors” like David Healy and Sarah Lisanby, this lunatic barbaric assault on the vulnerable continues.
          And, other philosophical articles and posts get 50, 100, 300 and more posts. ECT? Hey, lucky if one gets 10 or 12. It does not affect most people so they do not care.

          • I was truly disturbed when I read that “treatment resistant depression” only meant two trials of antidepressants, with NO requirement of any kind of psycho-social interventions, and NO proviso that the “depression” not be “situational” (as if there is any way to objectively determine THAT question!)

            The woman was, indeed, fortunate to talk to me, but this was also back in 1992 when citizen-based crisis lines were common and had not yet been co-opted by the “mental health” profession, as many of them now have (including the one I used to work for). I am sure it is much worse now. That was a huge dilemma for me – I felt ethically compromised working within the system, and yet if I had not been there, so many people would have had a worse experience. Eventually, I could not stand it any more (after several months doing involuntary detention evaluations and finding out what REALLY happens on a psych ward!) and got into advocacy instead. But I feel so badly for anyone innocently calling in for assistance these days, because there is a 90+ chance that the first thing that will happen to them is to be labeled and sent for drugs without any further exploration of options, and ECT has become a much more “acceptable” option than it was back in the 90s.

            It is a sick system!

            —- Steve

    • I couldn’t agree more about the ridiculous nature of the term’ ‘treatment resistant’ depression. It joins a long list of comments made to us by psychiatrists in the hospital that involved some form of circular reasoning.

      Thank you for your article Christopher. What impressed me the most is how carefully you write about your experience, acknowledging the uncertainty of what caused what etc. Thank you

      • Thanks for reading it!

        One thing I want to add is I did find out within the past 2-3 years through blood testing that I have a chronic vitamin D deficiency, but that when I take too much of it, somehow it interferes with my medications–making me feel jittery and I would get headaches when I took the SSRI. So I take vitamin D everyday now, but I try not to take more than 100% daily value. I also take magnesium with it everyday now, and I found that made some of headaches and jitteriness go away. That’s a real “chemical imbalance” I found I have, through actual physical tests, unlike the unproven “serotonin imbalance” that SSRIs supposedly treat, which almost no one gets tested for, so there’s no hard evidence that most patients on SSRIs even have a serotonin imbalance.

    • I am very confused by the fourth part of the definition of treatment resistant depression:
      “(iv) the absence of physical illness or psychosocial dysfunction, which should be the primary focus of treatment.”

      Does this mean that TRD is characterized by “the absence of physical illness or psychosocial dysfunction”? Perhaps I am not well informed, but the wording here suggests to me that someone diagnosed with treatment resistant depression has no physical illness and has no problems (dysfunction) in their psychological and social life.

      Seems to me that anyone with depression would have problems (dysfunction) in psychological and social life and that treatments tried should definitely include counseling and psychotherapy.

      But the only “treatment” the definition recognizes seems to be drug treatment.

  4. ECT is a barbaric practice, it what sends electrical shocks in your head and they admit side effects are memory loss much less a death reported.

    I understand there are people who are desperate for relief from being sad all the time, but to subject anyone involuntarily to this is deplorable.

    • Deplorable , I prefer the word despicable.

      Sometimes people call me out when I compare psychiatric practice to NAZI doctors and Josef Mengele and say I am going to far.

      Patient: Please, I don’t want 400 volts run through my brain, the seat of my consciousness, for up to 8 seconds and have a bunch of dangerous seizures.

      Doctor: Too bad, go willingly or we tie you down and do it anyway.

      I believe my NAZI comments are appropriate.

  6. RE: “I lived through forced ECT”

    How do you deal with the resentments ?

    I survived alot of psychiatric hell but in a large part I blame myself for falling for it, trusting them, walking into the trap myself and getting hurt. I did live years getting sick on their pills leading to their locked doors, strip search, dehumanization and then needle threats to try and coerce more of the drugs that made me sick in the first place but I was not assaulted and electrocuted !

    I have had therapy that did help me with the past even if it is kind of designed to teach people to be submissive and even like subservient along with “letting it go”.

    Keep up the activism and psychiatry can go to hell (back where it came from).

    • Thanks for sharing that–most of us MIA readers know how psychiatric treatment can become an endless cycle or spiral. Sometimes I still feel really angry about all the system put me through and at the doctors. At this point, all I can do is live with it as long as I’m alive. DBT did help me to accept that some things are out of my control or understanding and I try to remember that sometimes the best response is to be good to myself, rather than constantly focusing on the resentment or the people that caused it. Speaking out like this and knowing I’m informing other people helps. But yeah, I still feel angry sometimes. Sometimes it’s debilitating. Sometimes it fuels me.

      • I like to call the activism I do, online stuff like spreading links so more people find ‘anti psychiatry’ the human rights in mental health movement, paying it forward.

        This stuff saved me from who knows how much more keep me sick treatment, after the first person gave it to me by telling me about Mindfreedom.org and telling me psychiatry is a crock and opposition existed I got a hold of a book the Myth Of The Chemical Cure and was like WTF that’s how psychiatry really works, they are totally crooked and corrupt and that serotonin thing is total bull ? Screw this !

        Long story being sick for years and then at least a year to recover but finding the truth about psychiatry was the turning point. It changed everything.

        I guess the hardest part about doing online activism is that I have to read all the stuff and react to it before can add comments or post links to it.

      • I still feel angry sometimes. Sometimes it’s debilitating. Sometimes it fuels me.

        I have learned that in my own emotional world, the purpose of anger is action. That’s why my anger feels like fire- because its purpose is to fuel change. I get angry because something is wrong and needs to be changed. When I feel my anger instead of trying to tamp it down, I have clarity about what I need to address and change in my interaction with my world, and the physical experience of the anger fuels my ability to take action. Anger demands action, in fact, and if the changes needed are physical (re-arranging a room so that the processes that happen there can flow more functionally, for example), that’s great! But often the changes are to do with interpersonal relations, I still have to use up the energy or I experience a crash (that can easily and erroneously get labeled “depression”) and feel the need to retreat from the situation instead of dealing with it, which takes guts. Same thing happens if I subvert the anger experience entirely by tamping it down in the first place. I try to remind myself of this essential truth in the moment, and at least use the energy to scrub something that needs it– bathtub, oven, kitchen floor, whatever– even if I know I don’t have the guts to take on the big life changes that I know the anger is trying to demand. But that’s still only a temporary fix, until the situation shows its imbalance and creates more anger for me to change it!

        Anyway, that’s how anger works in my world, in case anyone finds that perspective useful.

  7. Christopher, I am so sorry that you’ve had such a rough ride getting help for your depression. I was a family therapist for 25 years, now writing fiction.

    I recently released my novel, THE RUBBER FENCE, inspired by my work on a psychiatric ward in 1972. I was a social worker in that hospital. In my novel, Dr. Joanna Bereza, a psychiatric intern tries to stop an arrogant shrink from shocking her patients.

    I’ve been surprised that there is now a resurgence of shock treatment. The arguments for and against that come up in my novel continue today.

    Wishing you all the best.