High Cost to Medicaid Programs For Off-Label Use of Antipsychotics
A study of 42 state Medicaid programs found that 58% of prescriptions for antipsychotics were not for schizophrenia or bipolar disorder. Off-label prescribing was most prevalent...
Antipsychotic Polypharmacy Commonly Prescribed Ahead of Guidelines
In one day at a psychiatric hospital in Vitoria-Gasteiz, Spain, of the 201 patients admitted 172 were prescribed antipsychotic drugs and 47% of those were...
Rampant Prescription Errors in CA Nursing Homes
Recent investigations by the California Department of Public Health found that in 18 of 31 nursing homes in San Francisco (plus one outside of...
Polypharmacy and Excessive Dosing
Researchers in Japan investigated 139 patients with schizophrenia diagnoses due to be discharged from 19 acute psychiatric units in Japanese hospitals. Polypharmacy and excessive...
45% of Children and Adolescent Inpatients Prescribed Antipsychotics
In a rare long-term study of antipsychotics used in children and adolescent inpatients, the Institute of Living in Hartford, CT followed 3,851 consecutive admissions...
Effort to Curb Antipsychotics for Dementia Announced
The Centers for Medicare and Medicaid Services is launching an initiative to curb the use of antipsychotic medications for nursing home residents with dementia....
Justice Department Raises J&J Settlement to $1.8 Billion
Following Johnson & Johnson's $158 million resolution with Texas several states have demanded higher payments, leading the U.S. Justice Department to raise its demand...
Popularity of Off-Label Antipsychotic Use Grows
Fueled by aggressive marketing that hyped atypical antipsychotics as safe and effective for off-label uses, states an article in The Washington Post yesterday, sales of the drugs...
$1 Billion J&J Settlement Rejected as Insufficient
Federal prosecutors have rejected as insufficient the $1 billion settlement reached two months ago between Johnson & Johnson and prosecutors in Philadelphia to resolve...
Shooter in Family Murder/Suicide on High Level of Antipsychotics
Denis Bay had high levels of prescription drugs used to treat schizophrenia and bipolar illness in his blood on February 3, when he shot...
Activity-Based Therapies Reduce Antipsychotic Use
Researchers from the University of North Carolina found that activity-based therapy and care reduced the use of antipsychotics in a study of 107 people...
High Levels of Antipsychotics in Shooter
Denis Bay had high levels of antipsychotics and mood stabilizers in his blood when he shot his wife and two daughters. 911 dispatchers described...
MRI Studies
During the 1990s, researchers using MRI technology discovered that antipsychotics shrink the frontal lobes and cause an enlargement of the basal ganglia. In the...
One Hundred Years of Schizophrenia
One Hundred Years of Schizophrenia. Hegerty, J. American Journal of Psychiatry 151 (1994):1409-1416.
In 1994, Harvard Medical School researchers reported that outcomes for schizophrenia patients in the U.S....
The Vermont Longitudinal Study & Correction of Seven Myths
In a long-term study of schizophrenia patients released during the late 1950s and early 1960s from the back wards of Vermont State Hospital, Courtenay...
The International Pilot Study of Schizophrenia
The International Pilot Study of Schizophrenia. Leff, J.Psychological Medicine, 22 (1992):131-145.
The first World Health Organization study that compared schizophrenia outcomes in "developed" and "developing" countries...
Drug-induced Supersensitivity Pscychosis
In the late 1970s, Canadian investigators identified the biological changes caused by antipsychotics that lead to the high relapse rates. Because the drugs dampen...
The Cure May Be Worse Than the Disease
Maintenance Antipsychotic Therapy. Cole, J. American Journal of Psychiatry, 132 (1977): 32-6.
In 1977, Jonathan Cole, the former head of the NIMH Psychopharmacology Service Center, concluded that...
Are There Schizophrenics for Whom Drugs May be Unnecessary or Contraindicated?
Are There Schizophrenics for Whom Drugs May be Unnecessary or Contraindicated? Rappaport, M. International Pharmacopsychiatry, 13 (1978), 100-111.
In this 1978 study, Maurice Rappaport and his colleagues at...
The Treatment of Acute Schizophrenia Without Drugs
The Treatment of Acute Schizophrenia Without Drugs. Carpenter, W. American Journal of Psychiatry, 134 (1977), 14-20.
In this 1977 NIMH study, 49 schizophrenia patients placed into an experimental...
Comparing five-year outcomes in the pre-Thorazine era and the post-Thorazine era.
Comparison of Two Five-Year Follow-up Studies.Bockoven, J. American Journal of Psychiatry, 132 (1975), 796-801.
In this study, Boston psychiatrists Sanbourne Bockoven and Harry Solomon compared relapse rates...
Discontinuation of Chemotherapy for Chronic Schizophrenics
Discontinuation of Chemotherapy for Chronic Schizophrenics. Prien, R. Hospital and Community Psychiatry, 22 (1971), 20-23.
In this NIMH study, the earlier finding that relapse rates rose in...
Relapse in Chronic Schizophrenics following Abrupt Withdrawal of Tranquilizing Medication
Relapse in Chronic Schizophrenics following Abrupt Withdrawal of Tranquilizing Medication. Prien, R. British Journal of Psychiatry, 115 (1968), 679-86.
The critical finding of this NIMH study was that...
NIMH’s First Follow-Up Study
a) One Year After Discharge. Schooler, N. American Journal of Psychiatry, 123 (1967):986-995.
This NIMH study looked at one-year outcomes for 299 patients who had been treated either...
Ongoing Brain Changes With Antipsychotic Treatment
Nancy Andreasen's 2003 study finding ongoing brain changes in persons with schizophrenia diagnoses, despite antipsychotic drug treatment.
Article → ...
