Wednesday, January 23, 2019

Better Outcomes Off Medication for Those Recovered from First-Episode Schizophrenia

A new study has found that of 10 people who were fully recovered from their first episode of schizophrenia (FES), those not taking antipsychotics did better in terms of cognitive, social, and role functioning—and reached full recovery more quickly.

Antipsychotics Associated with High Risk of Death in Children

A new study has found that children and adolescents taking a high dose of antipsychotics are almost twice as likely to die of any cause than children on other types of medications.

Claims That Long-term Antipsychotic Use Leads to Better Outcomes are Misleading, Researchers Argue

Researchers reveal the limitations and misleading interpretations of two recent studies that claim to demonstrate that long-term antipsychotic use leads to better outcomes.

Researchers Warn of “Brain Atrophy” in Children Prescribed Antipsychotics

Researchers discuss the evidence that antipsychotic medications may cause brain atrophy in children, whose brains are still developing.

Gradual Tapering is Most Successful for Withdrawal from Antipsychotics

Mixed-Methods study explores the experiences of antipsychotic discontinuation among service users.
evidence base for neuroleptics

How Well Do Neuroleptics Work?

A recent paper published in Schizophrenia Bulletin reported on a meta-analysis of antipsychotic drugs which found that a significant number of people do not experience a remission of psychotic symptoms. The evidence base suggests that it is time for us to reappraise the effectiveness of these drugs and shift our practice patterns accordingly.

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

New Review of Antipsychotics for Schizophrenia Questions Evidence for Long Term Use

A systematic review of the limited research available on the long-term effects of antipsychotics finds fewer symptoms in those off of the drugs.

New Research on Patient-Centered Deprescribing for Antipsychotics

Researchers review the risks and benefits of deprescribing from antipsychotic drugs and advocate for a patient-centered approach to tapering.
antipsychotics survey

Did You Ever Stop Taking Antipsychotics? – World Survey on Withdrawal

Antipsychotics are big business, professionals are often at a loss as to how to help people going through disturbing experiences, the voices of patients are crowded out of the equation — there are many reasons for the lack of real education and informed consent around antipsychotics. To address this gap in knowledge, we launched a world study on antipsychotic medication withdrawal.

Call to Monitor Adverse Effects of Antipsychotics in Youth

Researchers point to the risks of using antipsychotics with youth and caution against the practice.

Study Shows Success With Reduced Antipsychotic Use

People who reduced antipsychotic use by tapering were doing just as well after five years as those who continued using the drugs.

Study Reduces Over-prescription of Antipsychotics in Older Adults

New intervention shows promise in reducing over-prescription of off-label antipsychotics in older adults.

What Are Best Practices For Psychosis And What Gets In The Way?

Research investigates clinicians’ perspectives on best care practices and the complicated realities of providing care in the face of agency limitations and mechanized interventions.

New Research Suggests Brain Abnormalities in ‘Schizophrenia’ May Result From Antipsychotics

Study finds that reduced cortical thickness and brain surface area associated with 'schizophrenia' may result from antipsychotic drug use.

Poor and Foster Care Children More Likely to be Diagnosed and Treated with Psychiatric...

Study details Medicaid-insured birth cohort’s exposure to psychiatric medications and mental health services.

FDA Defends Decision to Approve Digital Aripiprazole

Members of the U.S. Food and Drug Administration’s Psychiatry Products division go on the defensive in a new article, responding to concerns about the agency’s approval of digital aripiprazole.
risk versus reward

Randomized Controlled Trials of Psychiatric Drugs Tell of Harm Done

The most important data in an RCT is not whether the drug provides a statistically significant benefit over placebo. The most important data is the “number needed to treat” calculation (NNT). For the person considering taking an antidepressant or an antipsychotic, the NNT data provides the “math” needed to weigh the potential benefit of taking the drug against the potential harm of doing so.

Mental Health Industry Should Embrace Choices Beyond Drugs

In this video for NowThis, Yana Jacobs critiques the mental health industry standard of prescribing drugs as the first-line treatment for "mental illness." She emphasizes...

Medical Malpractice Verdict Seen as Powerful Message

From PR Newswire: On May 16th, a $2 million verdict was issued in favor of Stanley and Marianne Truskie, whose son died from toxic levels...

The Sound of Madness

From Harper's Magazine: People who hear positive, encouraging voices often seen as spiritual guides or messages and people diagnosed with schizophrenia are usually thought of as...

The Never-Ending Misuse of Antipsychotics in Nursing Homes

From Health Affairs: Although the problem of antipsychotic misuse in nursing homes has been raised to policymakers numerous times over the past six decades, the...
antipsychotic study 2

Antipsychotics Said to Lower Mortality and Relapse Rates Over Long Term

In a recently published study, researchers concluded that first-episode schizophrenia patients who take antipsychotics continuously have lower mortality and lower risk of being rehospitalized than those who discontinue the drugs. Joanna Moncrieff and Sandy Steingard investigate the findings.
antipsychotic study magnifying glass

A Commentary on the Finnish Analysis of Outcomes of First Episode Schizophrenia

There are a number of well-recognised problems with this sort of study and we should be very cautious about accepting its conclusions at face value. The main problem is that it is an ‘observational’ study, not a randomised controlled trial, and these analyses can be seriously misleading. 
antipsychotic study bottle 2

20-year Outcomes for First-episode Psychosis: Impact of Neuroleptic Drug Discontinuation

The authors conclude that the risk of treatment failure or relapse after discontinuation of antipsychotics does not decrease during the first eight years of illness, and that long-term antipsychotic treatment is associated with increased survival. This is a sobering finding and the paper warrants careful review.

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