Psychiatric Drugs

When I wrote Anatomy of an Epidemic, one of my foremost hopes was that it would prompt mainstream researchers to revisit the scientific literature. Was there evidence that any class of psychiatric medications—antipsychotics, antidepressants, stimulants, benzodiazepines, and so forth—provided a long-term benefit? Now epidemiologists at Columbia University and City College of New York have reported that they have done such an investigation about antipsychotics, and their bottom-line finding can be summed up in this way: Psychiatry’s “evidence base” for long-term use of these drugs does not exist.

Researchers from the City College of New York and Columbia University published a study this month testing the hypothesis that people diagnosed with schizophrenia treated long-term with antipsychotic drugs have worse outcomes than patients with no exposure to these drugs. They concluded that there is not a sufficient evidence base for the standard practice of long-term use of antipsychotic medications.

Listen: NPR’s On Point with Tom Ashbrook discusses the new book “Moody Bitches: The Truth About the Drugs You’re Taking, The Sleep You’re Missing, the Sex You’re Not Having and What’s Really Making You Crazy,” by the psychiatrist Julie Holland.

Benedict Carey at the New York Times covers the push for new programs that emphasize supportive services, therapy, school and work assistance, and family education, rather than simply drug treatment.

Children of parents who suffer from depression have a severely heightened risk of mental health problems, but new research points to several factors that seem to strengthen young peoples’ resilience and predict good mental health.

Miriam Stoppard writes an opinion piece on the lack of good research on Ritalin, a drug often used for ADHD, and discusses the latest Cochrane review which found a high percentage of side-effects in children. Despite the lack of quality evidence, “NHS figures show that nearly one million ADHD prescriptions were handed out last year in England – a number that has more than doubled in 10 years.”

September 11^th 2015 was my last day working as a counselor/therapist in the U.S. community mental health system. After 22 years working within that system I resigned out of protest having waged a concerted effort (2½ years) to challenge potentially dangerous psychiatric drug prescribing patterns at my workplace. In late April of this year these challenges led to the filing of a major complaint with the Massachusetts Dept. of Mental Health and eventually the Dept. of Public Health. I never expected to discover just HOW unprepared, dysfunctional, and totally oblivious the entire state bureaucracy is when it involves any serious complaints detailing possible abuses and harm being done to its citizens by a branch of medicine called Psychiatry. Just how broken is "Broken"?

"To be sure, the FDA review process is not perfect. What is? But the agency is still considered the gold standard by which other...

Rob Wipond takes HealthNewsReview.org to task for its coverage of a Philadelphia Inquirer article about a medical device designed for people experiencing panic. He writes that “hyperbolic psychiatric and psychological claims frequently get free passes from otherwise thoughtful medical critics.”

“In 2014, the number of people who died from drug overdoses in the United States reached 47,055 — an all-time high, according to a disturbing report published Friday by the Centers for Disease Control and Prevention (CDC),” but “the effort to get physicians to curb their prescribing of these drugs may be faltering amid stiff resistance from drugmakers, industry-funded groups and, now, even other public health officials.”

Experiencing emotional pain is a necessary part of life. Emotional pain often contains valuable lessons to help us on our journeys. We need to make sure we are not numbing our hearts to those that are hurting. We need to de-stigmatize the struggles, joys and pains that come with being human. We need to not just mindlessly pursue happiness - though we might think of that as an inalienable right - and avoid pain. We need to do the only thing that brings true joy: embrace all of life and each other, as we experience together all that makes us human.

This week another study was published showing that SSRI antidepressant use during pregnancy is associated with increased rates of autism in the children.  By my count, this is now the tenth study on this topic and it follows on the heels of previous studies – all of which found links between SSRI antidepressant use in pregnancy and autism in the offspring.  Most of these studies were recently reviewed by Man, et al, who also concluded that SSRI antidepressant use during pregnancy is associated with autism in the children. So we now have numerous studies in different human populations all showing a link between SSRI use in pregnancy and autism in the children. Yet, much of the news and blogosphere focus on casting doubts about these findings. What is going on here?

Recent meta-analyses of antidepressant clinical trials have revealed that up to 82% of the effects associated with the drugs may be attributed to placebo and non-medication factors. A new study examined the attitudes of psychiatrists toward these non-pharmacologic factors and found a large discrepancy between their beliefs and the empirical evidence.

In the context of the Silicon Valley suicides, one mother offers her story about her daughter. “It’s my premise that not only the culture of Silicon Valley, but also, almost more importantly, the nature of the remedies that are being proposed in the name of mental health counseling, are to blame in these deaths.”

“A group of Boston doctors is proposing to join a study that would provide emergency treatment for brain-injured patients without obtaining the trauma victims’...

“A new study is giving insight into how long-term care patients in the province are progressing — or, in some cases, worsening — over time. It found those living in central Newfoundland are more likely to be given antipsychotic drugs they don't need.”

In a series of experiments in mice, researchers found that the drug risperidone alters gut microbes, which in turn profoundly influence metabolism, weight, and overall health.

The Daily Telegraph reports on a warning published in the Medical Journal of Australia that urges doctors not to “jump the gun in prescribing patients the drug ketamine to treat depression.”

An analysis of medical records in the UK reveals that the use of certain antidepressants for depression is linked to a heightened risk for mania and bipolar disorder. The research, published this week in BMJ Open, found the strongest effect for serotonin reuptake inhibitors (SSRIs) and the antidepressant venlafaxine.

A new study demonstrates that the practice of mindfulness may ease pain in a way that is mechanistically distinct from the placebo effect. Research, published in the Journal of Neuroscience, found that mindfulness meditation not only outperformed placebo and fake meditation for pain relief but that it also activated different brain regions than the placebo treatments.

A former pharma executive has broken ranks with the industry in a new book by reporting how multiple psychiatrists, schools, and his desperate hopes pressed him to allow higher and higher doses of antipsychotic medications. The result: his 15-year-old son's death from Seroquel.

Critical psychiatry researcher, anthropologist and NYU professor Helena Hansen writes: “Opioid maintenance acts as a kind of pharmaceutical prosthesis which promises to return white ‘addicts’ to regaining their status as full human persons and middle-class consumers. Meanwhile, black and brown users are not deemed as persons to be rescued, but rather dangerous subjects to be pharmaceutically contained within the public discipline of the state.”

In a major study, published yesterday in JAMA Pediatrics, the use of SSRI antidepressants during pregnancy was found to increase the risk of autism spectrum disorder (ASD) by 87-percent. Previous studies reveal that more than 13-percent of women currently use SSRI antidepressants during pregnancy.

“Some autistic adults have spent much of their lives with the wrong diagnosis, consigned to psychiatric institutions or drugged for disorders they never had,” Jessica Wright writes in The Atlantic.

A new study in JAMA reveals that, on average, 25% of beginning physicians meet the diagnostic criteria for major depression. In an accompanying editorial, Dr. Thomas Schwenk, added: "Everybody asks me, because of some of my prior studies, should we have more intense work in diagnosing depression in students? Of course, the answer is 'yes,' but how do you go about that without further stigmatizing them, further labeling them, further singling them out to even greater stigma? It's not just an issue of, 'Let's make better diagnoses and let's provide better treatment'; it’s more complicated than that."