Tuesday, September 29, 2020

More Evidence Antipsychotics Reduce Brain Volume

People diagnosed with schizophrenia experience reductions in brain volume that increase over time, and the amount of those reductions increases in proportion to the...

Antipsychotics Again Strongly Linked to Falls and Fractures

Three independent studies in two journals reported strong links between antipsychotics and falls and fractures.

In Chronic Patients, Antipsychotics Have Limited Efficacy in Reducing Symptoms

A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

Review Explores First-Person Experiences of People Taking Antipsychotics

A new systematic review finds that patients report reduced symptoms but also loss of self and agency while taking antipsychotics.

More Evidence That Antipsychotics Shrink the Brain

European researchers who reviewed 43 imaging studies of first-episode psychosis found evidence that antipsychotics cause a decrease in gray matter volumes in the brain....

Researchers Discover How Antipsychotics Lead To Parkinsonism

A new study published this month in the journal Neuron identifies the mechanism by which antipsychotic drugs can induce parkinsonism, a condition involving movement...

Non-Drug Therapies Outperform Drug Therapies in Preventing Relapse

In a study of 597 outpatients who were perceived as likely nonadherers to oral antipsychotic interventions, Spanish researchers found that relapse was lower in...

Psychiatric Drugs, Especially Antipsychotics, Contribute to Increasing Drug Costs

Antipsychotics have overtaken antidepressants as the most costly class of psychiatric medication in England, according to a study by Stephen Ilyas and Joanna Moncrieff...

Antipsychotics Prescribed Off-Label for Challenging Behaviors

Antipsychotics are being prescribed to people who may have challenging behaviors but no mental disorder, according to new research published in this month’s issue of BMJ. “Excessive use of psychotropic drugs has individual and systemic implications,” the researchers write. “Antipsychotics, in particular, are associated with several adverse side effects that can impair quality of life and lead to deleterious health outcomes.”

Family Economic Context Linked to Adolescents’ Antipsychotic Use

In a study of the Swedish Medical Birth Registry published in the British Medical Journal, researchers identified all 324,510 single children born between 1988...

Psychiatrists’ Prescriptions for First-time Psychosis Often Don’t Follow Guidelines

"Many patients with first-episode psychosis receive medications that do not comply with recommended guidelines for first-episode treatment," states a National Institute of Mental Health...

Scant Evidence for Combining Antipsychotics

Researchers in Barcelona, Spain retrospectively reviewed the use of antipsychotics in 117,811 patients, of whom 9,855 were given combinations of antipsychotics and 13,763 were...

Largest Survey of Antipsychotic Experiences Reveals Negative Results

A new survey exploring antipsychotic user experience finds that more than half of the participants report only negative experiences.

Claims That Long-term Antipsychotic Use Leads to Better Outcomes are Misleading, Researchers Argue

Researchers reveal the limitations and misleading interpretations of two recent studies that claim to demonstrate that long-term antipsychotic use leads to better outcomes.

Some Avoid Antipsychotics Because They Value Psychosis

Side effects, mistrust, stigma, forgetfulness and lack of insight have all been studied as reasons that up to 75% of people with a schizophrenia...

Review Links Antipsychotics with Risk for Heart Attacks

A systematic review published this week in the British Journal of Clinical Pharmacology found that patients taking antipsychotic drugs were at nearly twice the risk...

New Review of Antipsychotics for Schizophrenia Questions Evidence for Long Term Use

A systematic review of the limited research available on the long-term effects of antipsychotics finds fewer symptoms in those off of the drugs.

Antipsychotic Drug Associated with Potentially Fatal Skin Rash

The US Food and Drug Administration is warning the public that the antipsychotic medication ziprasidone "is associated with a rare but serious skin reaction...

Antipsychotics Too Often Used to Dampen Aggression in Kids, Not Treat Psychosis

Antipsychotics appear to be too often prescribed to curb aggressive impulses in children and youth, rather than to treat psychosis or any other clinically indicated conditions.

Identifying Psychiatric Drugs Leading to Emergency Room Visits

More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.

A History of Rapid Tranquilization

A paper by Joanna Moncrieff and Laura Allison in the journal History of Psychiatry reviews "the theory and practice of emergency sedation for behavioural...

How Exercise Can Help With First Episode Psychosis

New study examines the experiences of people utilizing an exercise program following a first-episode psychosis.

Slew of New Studies Spot Links Between Psychiatric Medications and Bone Loss, Fractures

Four different studies conducted in different ways examining different groups have linked use of certain psychiatric drugs to bone fracture risks and negative impacts on human bone development.

Alarm About Antipsychotics as Sleep Aids

Canadian sleep researchers, writing in The Lancet, warn that weight gain, lipid and glucose dysregulation, restless leg syndrome, sleep-walking and eating while asleep, and...

Antipsychotics Triple the Risk of Diabetes in Children and Youth

Researchers from Vanderbilt and Columbia Universities and the FDA find that, through a retrospective cohort study of 28,858 patients of the Tennessee Medicaid program...

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