Monday, December 9, 2019

Multiple Medications Associated With Poorer Outcomes

Research from Germany finds that people with schizophrenia or schizoaffective diagnoses given multiple medications - an antipsychotic plus a benzodiazepine or more than one...

Review Links Antipsychotics with Risk for Heart Attacks

A systematic review published this week in the British Journal of Clinical Pharmacology found that patients taking antipsychotic drugs were at nearly twice the risk...

Smoking Cessation and Psychiatric Drugs Cause the Most Suicidal and Homicidal Reactions

The popular smoking cessation drug Chantix is the medication that most frequently makes people feel suicidal or homicidal, according to figures gathered by the...

Claims That Long-term Antipsychotic Use Leads to Better Outcomes are Misleading, Researchers Argue

Researchers reveal the limitations and misleading interpretations of two recent studies that claim to demonstrate that long-term antipsychotic use leads to better outcomes.

Meta-Analysis Ties Gray Matter Loss to Antipsychotic Dose

Antipsychotics are currently the predominant treatment for individuals diagnosed with schizophrenia, but there is an accumulating body of research that links the use of these drugs to structural abnormalities in the brain. A recent meta-analysis suggests that gray matter loss in the brain may depend on the dose and class of the antipsychotic.

Antipsychotics Prescribed Off-Label for Challenging Behaviors

Antipsychotics are being prescribed to people who may have challenging behaviors but no mental disorder, according to new research published in this month’s issue of BMJ. “Excessive use of psychotropic drugs has individual and systemic implications,” the researchers write. “Antipsychotics, in particular, are associated with several adverse side effects that can impair quality of life and lead to deleterious health outcomes.”

Cognitive Function Improved by Reducing Antipsychotics

A 28-week randomized controlled study by researchers in Japan, Canada and the United States finds that a 50% reduction of risperidone or olanzapine significantly...

Reducing Antipsychotic Use May Improve Health for People with Mental Health Diagnoses

A new study offers radical solutions for improving the cardiovascular health of people with mental health diagnoses: reducing antipsychotic prescriptions..

“Antipsychotic Use in Youth Without Psychosis: A Double-edged Sword”

This month’s issue of JAMA Psychiatry ran an editorial commenting on recent research revealing that the majority of youth prescribed antipsychotics have not been diagnosed with a mental disorder.

Study Explores Cognitive Effects of Antipsychotics

Reduced usage of antipsychotics in first-episode psychosis was associated with improved executive functioning.

Antipsychotic Use Does Not Correlate With Conversion to Psychosis

Researchers in Brazil find, in a meta-analysis, that only 30% of youth deemed to be of ultra high risk of psychosis do in fact...

Drug Treatment for Borderline Personality Disorder Not Supported By Evidence

New research published in the August issue of Psychiatric Annals evaluates the results of randomized control trials on the use of various psychotropic drugs for patients diagnosed with borderline personality disorder (BPD). Despite the “American Psychiatric Association’s practice guidelines endorsement of SSRIs as first-line therapies for BPD,” the results of the meta-analysis reveal that pharmacotherapy in BPD is “not supported by the current literature,” and “should be avoided whenever possible.”

Antipsychotics Increase Risk of Heart Attack in the Elderly

In a study of 10,969 older patients treated with antipsychotics in Quebec, Canada, researchers found a 2.19 times greater risk of heart attack in...

Antipsychotics Linked to Cognitive & Memory Impairments

Finnish reseachers report in Schizophrenia Research that antipsychotic use is associated with cognitive and memory impairments. The University of Oulu team studied forty people...

“Janssen Accused of Withholding Data on Risperdal Side Effect in Autism”

MedPageToday reports that Janssen Pharmaceuticals omitted data from a 2003 study that connected Risperdal with serious side effects. Janssen was previously sued by the FDA for marketing Risperdal for off-label uses and settled for $2.2 billion in 2013. Earlier this year, a man with autism was awarded $2.5 million after growing breasts while on Risperdal. According to MedPage, documents from this latest case reveal missing data tables from a 2003 study “designed to ferret out potential adverse effects of long-term risperidone use.” The missing tables were related to elevated prolactin levels and side effects, including gynecomastia in men.

Antipsychotics are Poor Sleep Aids

Research from Australia shows that "remained pervasive" in 70% of a sample of 83 patients medicated with antipsychotics and other medications, and concludes that...

Family Economic Context Linked to Adolescents’ Antipsychotic Use

In a study of the Swedish Medical Birth Registry published in the British Medical Journal, researchers identified all 324,510 single children born between 1988...

Why the Delay Between Psychotropics’ Immediate and “Therapeutic” Effects?

Writing in Neuron that antipsychotics' "functional consequences and the subcellular sites of their accumulation in nervous tissue have remained elusive," researchers from Germany and...

Common Parkinson’s Drugs Linked to Pathological Gambling and Hypersexuality

"Pathological gambling, hypersexuality, compulsive shopping and other impulse control disorders were associated with the use of dopamine receptor agonists, often prescribed for Parkinson’s disease,...

Anticholinergic Medications Linked to Dementia Similar to Early Alzheimer’s

A new study, published in the Journal of Clinical Psychiatry, investigates the effects of anticholinergic medications, such as antidepressants and antipsychotics, on cognition in older adults diagnosed with schizophrenia.

Antipsychotic Dose Reduction Linked To Long-term Improvements In First-Episode Schizophrenia Patients

Careful reductions in dosage levels of antipsychotic medications over time improved long-term rates of recovery and functional remission in patients diagnosed with a first-episode psychosis.

FDA Warns About New Impulse-Control Problems Associated With Abilify

Yesterday, the US Food and Drug Administration (FDA) released a warning that the antipsychotic drug aripiprazole or Abilify is associated with compulsive and uncontrollable...

“Should We Stop Using Antipsychotic Medication?”

In a recent interview, Nancy Andreasen, former editor-in-chief of the American Journal of Psychiatry, reaffirmed her earlier findings that antipsychotics shrink brain tissue. "We spent a couple...

Antipsychotics Again Strongly Linked to Falls and Fractures

Three independent studies in two journals reported strong links between antipsychotics and falls and fractures.

Antipsychotics Change the Architecture of the Colon

Researchers in Singapore find that antipsychotic medications are associated with changes to colonic architecture, which could result in difficult colonoscopy and increased colonoscopy-related risks....

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