Monday, December 9, 2019

Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption

Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.

Withdrawal from Antipsychotics

A review of the scientific literature related to the withdrawal of antipsychotics: animal studies, withdrawal symptoms, tapering success rates, and consumer accounts of discontinuation.

The Case Against Antipsychotics

This review of the scientific literature, stretching across six decades, makes the case that antipsychotics, over the long-term, do more harm than good. The drugs lower recovery rates and worsen functional outcomes over longer periods of time.

Danish Study Finds Better 10-year Outcomes in Patients Off Antipsychotics

Study finds that 74% of patients with a psychotic disorder off antipsychotics at end of 10 years are in remission.

Anticholinergic Psychiatric Drugs Linked to a 50% Increase in Dementia

People who take anticholinergic drugs, such as antidepressants and antipsychotics, are at a 50% higher risk of dementia.

New Research Suggests Brain Abnormalities in ‘Schizophrenia’ May Result From Antipsychotics

Study finds that reduced cortical thickness and brain surface area associated with 'schizophrenia' may result from antipsychotic drug use.

A Tale of Two Studies

With increasing evidence that psychiatric drugs do more harm than good over the long term, the field of psychiatry often seems focused on sifting through the mounds of research data it has collected, eager to at last sit up and cry, here’s a shiny speck of gold! Our drugs do work! One recently published study on withdrawal of antipsychotics tells of long-term benefits. A second tells of long-term harm. Which one is convincing?

Antipsychotic Medications Are Causing Obsessive Compulsive Disorders

Common second-generation antipsychotic medications are causing symptoms of obsessive-compulsive disorder to emerge in many people who previously only had schizophrenia symptoms, according to a...

Safety Analysis Weighs Harms and Benefits of Antipsychotic Drugs

The researchers find that the drug effects for reducing psychosis are small and that treatment failure and severe side effects are common.

Antipsychotics Linked to Cognitive & Memory Impairments

Finnish reseachers report in Schizophrenia Research that antipsychotic use is associated with cognitive and memory impairments. The University of Oulu team studied forty people...

Study Suggests Long-Term Antipsychotic Use May Result in Poorer Cognitive Functioning

Association found between long-term antipsychotic use and poorer performance on cognitive tasks in adults diagnosed with ‘schizophrenia.’

Study Finds Improved Functioning for ‘Schizophrenia’ Without Antipsychotics

Long-term treatment with antipsychotic drugs is currently considered the standard treatment for patients diagnosed with ‘schizophrenia.’ A new study challenges this practice, however. The...

A Guide to Minimal Use of Neuroleptics

This guide, by psychiatrists Volkmar Aderhold and Peter Stastny, provides a comprehensive review of antipsychotics and an evidence-based rationale for avoiding their use in first-episode psychosis, and for minimizing their long-term use.

Patients With Schizophrenia Show Better Work Functioning Off Antipsychotics

20-year follow-up study finds that after four years, patients not prescribed antipsychotics have significantly better work functioning.

Review Questions Long Term Use of Antipsychotics

Patients who recover from a single episode of psychosis are often prescribed antipsychotics long-term, despite a lack of evidence for this practice

Scientists Clarify Risks of Augmenting with Antipsychotic Medications for Depression

The researchers found that while antipsychotic drugs may be slightly more effective than alternative antidepressants, they come with a much higher side effect burden.

Researchers Warn of “Brain Atrophy” in Children Prescribed Antipsychotics

Researchers discuss the evidence that antipsychotic medications may cause brain atrophy in children, whose brains are still developing.

Study Shows Clozapine Can Result in Serious Gastrointestinal Complications

A large observational study published in CNS Drugs sheds light on serious adverse effects of the ‘gold standard’ antipsychotic Clozapine.

Reduction/Discontinuation of Antipsychotics Produces Higher Long-Term Recovery

A study published today in the American Medical Association's journal JAMA Psychiatry reports that patients whose antipsychotic treatment was reduced or discontinued (DR) experienced a recovery...

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

FDA Warns About New Impulse-Control Problems Associated With Abilify

Yesterday, the US Food and Drug Administration (FDA) released a warning that the antipsychotic drug aripiprazole or Abilify is associated with compulsive and uncontrollable...
Yellow sign reading "Cognitive Hazard"

Discontinuation of Antipsychotics Improves Cognitive Functioning

A study, recently published in Psychological Medicine, examined the cognitive functioning of individuals with schizophrenia who discontinued antipsychotics, and those who maintained their antipsychotic...

Better Outcomes Off Medication for Those Recovered from First-Episode Schizophrenia

A new study has found that of 10 people who were fully recovered from their first episode of schizophrenia (FES), those not taking antipsychotics did better in terms of cognitive, social, and role functioning—and reached full recovery more quickly.

Abilify Can Worsen Psychosis & Aggression

In a systematic literature review, researchers from Canada and Japan found that the antipsychotic aripiprazole (Abilify) was significantly and causally related to increased increased...

In Chronic Patients, Antipsychotics Have Limited Efficacy in Reducing Symptoms

A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

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