Breaking Blind: Antipsychotic Drug Efficacy May Be Overestimated
Only 4 of 188 antipsychotic trials assessed blinding, and in all 4 cases, the blind was broken, potentially leading to an overestimation of the drug effect.
Industry Corruption in Systematic Review for Injectable Antipsychotics
Researchers highlight how systematic reviews are compromised by pharmaceutical industry ties by exposing a study of injectable antipsychotics.
Many Service Users Interested in Decreasing Antipsychotic Use with Professional Help
New research examines service user attitudes on discontinuing and reducing antipsychotic drugs.
Antipsychotics Often Prescribed Without Informed Consent
New research reveals that patients are often not given fully informed consent before being prescribed antipsychotics.
Antipsychotics Worsen Cognitive Functioning in First-Episode Psychosis
Withholding antipsychotics may be beneficial for memory, the researchers write.
Manufacturer of Tardive Dyskinesia (TD) Drugs Finds TD Emotionally Devastating
“Patients expressed feeling unaccepted by society or uncomfortable in their own skin… A few indicated that they would rather be dead than have tardive dyskinesia.”
Antipsychotics Linked to Increased Breast Cancer Risk
Long-term exposure to prolactin-increasing antipsychotics increases the odds of developing breast cancer.
New Rating Tool for Tapering Antidepressants and Antipsychotics
Researchers developed a rating scale to better assess service users’ experiences tapering antidepressant and/or antipsychotic medication.
Antipsychotics Increase Risk of Dementia; New Research Illuminates Why
In JAMA psychiatry, researchers outline new theories connecting antipsychotic use in people with schizophrenia and increased dementia risk.
Tapered Antipsychotic Withdrawal Mitigates Risk of Psychotic Symptoms
Research suggests that slowly tapering off an antipsychotic reduces the risk of withdrawal psychosis compared to abrupt discontinuation.
Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse
A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.
Antipsychotic Adherence Research Overlooks Key Information
Researchers argue for a shift away from a focus on antipsychotic adherence toward understanding service users’ diverse patterns of use.
New Study: The Clinical High Risk for Psychosis (CHR-P) Model Is Flawed
The CHR-P model focuses on “attenuated psychosis” to predict “transition” to schizophrenia and ignores other factors. But new research shows that the model is a poor predictor.
Barriers to Shared Decision Making in the Prescription of Antipsychotics
Researchers push for a renewed focus on true shared decision-making for patients diagnosed with psychosis.
Anticholinergic Medications Linked to Cognitive Impairment in Schizophrenia
Researchers have found further evidence that the anticholinergic effect of psychiatric drugs can lead to cognitive impairments.
Keys to Successful Discontinuation of Antipsychotic Medication
Qualitative study finds that both internal resources and systemic factors play a role in antipsychotic discontinuation outcomes.
The BBC, Harrow, and a Public Left in the Dark
The recent report by the BBC on medication-free treatment in Norway, when viewed in conjunction with the media silence on Martin Harrow's latest publication, reveals why the public remains misinformed about the long-term effects of antipsychotics.
Recovery Rate Six Times Higher For Those Who Stop Antipsychotics Within Two Years
People with "serious mental illness" who stop taking antipsychotics are more likely to recover, even when accounting for baseline severity.
Anticholinergic Drugs Increase Risk of Cognitive Decline
A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.
Antipsychotic Augmentation Increases Risk of Death
A new study finds that adding an antipsychotic to existing antidepressant treatment is associated with a 45% increased risk of early death.
Greater Exposure to Antipsychotics Associated with Worse Long-Term Outcomes
A new study finds adverse long-term consequences associated with the increased use of antipsychotics in first-episode psychosis.
Very Slow Taper Best for Antipsychotic Discontinuation
An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.
Antipsychotics Associated with Severe COVID-19 and Fatal Outcomes
A new study has found a strong association between antipsychotic drugs and higher rates of severe cases of COVID-19.
For People “At Risk for Psychosis,” Antipsychotics Associated with Worse Outcomes
Researchers studied whether antipsychotics could prevent transition to full psychosis and found that the drugs worsened outcomes.
Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain
A new study published in JAMA Psychiatry connects antipsychotics with damage to the brain in multiple areas.