Friday, October 15, 2021

Manufacturer of Tardive Dyskinesia (TD) Drugs Finds TD Emotionally Devastating

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“Patients expressed feeling unaccepted by society or uncomfortable in their own skin… A few indicated that they would rather be dead than have tardive dyskinesia.”

Antipsychotics Linked to Increased Breast Cancer Risk

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Long-term exposure to prolactin-increasing antipsychotics increases the odds of developing breast cancer.

New Rating Tool for Tapering Antidepressants and Antipsychotics

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Researchers developed a rating scale to better assess service users’ experiences tapering antidepressant and/or antipsychotic medication.

Antipsychotics Increase Risk of Dementia; New Research Illuminates Why

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In JAMA psychiatry, researchers outline new theories connecting antipsychotic use in people with schizophrenia and increased dementia risk.

Tapered Antipsychotic Withdrawal Mitigates Risk of Psychotic Symptoms

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Research suggests that slowly tapering off an antipsychotic reduces the risk of withdrawal psychosis compared to abrupt discontinuation.

Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse

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A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.

Antipsychotic Adherence Research Overlooks Key Information

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Researchers argue for a shift away from a focus on antipsychotic adherence toward understanding service users’ diverse patterns of use.
Question mark inside a maze in the shape of human head.

New Study: The Clinical High Risk for Psychosis (CHR-P) Model Is Flawed

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The CHR-P model focuses on “attenuated psychosis” to predict “transition” to schizophrenia and ignores other factors. But new research shows that the model is a poor predictor.
Doctor and patient

Barriers to Shared Decision Making in the Prescription of Antipsychotics

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Researchers push for a renewed focus on true shared decision-making for patients diagnosed with psychosis.

Anticholinergic Medications Linked to Cognitive Impairment in Schizophrenia

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Researchers have found further evidence that the anticholinergic effect of psychiatric drugs can lead to cognitive impairments.

Keys to Successful Discontinuation of Antipsychotic Medication

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Qualitative study finds that both internal resources and systemic factors play a role in antipsychotic discontinuation outcomes.

The BBC, Harrow, and a Public Left in the Dark

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The recent report by the BBC on medication-free treatment in Norway, when viewed in conjunction with the media silence on Martin Harrow's latest publication, reveals why the public remains misinformed about the long-term effects of antipsychotics.

Recovery Rate Six Times Higher For Those Who Stop Antipsychotics Within Two Years

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People with "serious mental illness" who stop taking antipsychotics are more likely to recover, even when accounting for baseline severity.

Anticholinergic Drugs Increase Risk of Cognitive Decline

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A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.
antipsychotic drugs

Antipsychotic Augmentation Increases Risk of Death

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A new study finds that adding an antipsychotic to existing antidepressant treatment is associated with a 45% increased risk of early death.

Greater Exposure to Antipsychotics Associated with Worse Long-Term Outcomes

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A new study finds adverse long-term consequences associated with the increased use of antipsychotics in first-episode psychosis.

Very Slow Taper Best for Antipsychotic Discontinuation

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An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

Antipsychotics Associated with Severe COVID-19 and Fatal Outcomes

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A new study has found a strong association between antipsychotic drugs and higher rates of severe cases of COVID-19.

For People “At Risk for Psychosis,” Antipsychotics Associated with Worse Outcomes

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Researchers studied whether antipsychotics could prevent transition to full psychosis and found that the drugs worsened outcomes.

Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain

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A new study published in JAMA Psychiatry connects antipsychotics with damage to the brain in multiple areas.

Antipsychotic Trials Show Increasing Placebo Response and Declining Drug Response

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A new review of antipsychotic trials conducted over the last 24 years finds that the placebo response rate is steadily increasing, and drug response is decreasing.

Does Longer Duration of Untreated Psychosis Cause Worse Outcomes?

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New research counters the long-held assumption that a longer duration of untreated psychosis is associated with worse outcomes.

Largest Survey of Antipsychotic Experiences Reveals Negative Results

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A new survey exploring antipsychotic user experience finds that more than half of the participants report only negative experiences.

Review Explores First-Person Experiences of People Taking Antipsychotics

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A new systematic review finds that patients report reduced symptoms but also loss of self and agency while taking antipsychotics.

Relapse in Antipsychotic Drug Trials is Poorly Defined

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There is a lack of consensus in the definition of ‘relapse’ across randomized controlled trials of antipsychotic maintenance treatment for schizophrenia and psychosis.

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