Tuesday, January 26, 2021

2nd-Generation Antipsychotics Cause Extrapyramidal Side Effects as Much as 1st-Generation

According to researchers from Yale and the U.K., the improvements in extrapyramidal side effects expected from 2nd-generation antipsychotics has not been realized, while the...

Outcome Reporting Bias in Antipsychotic Medication Trials

A new study in the journal Translational Psychiatry, an influential journal in biological psychiatry published by Nature, challenges the state of the research on antipsychotic drugs.

Pharmacological Treatment of Schizophrenia: a Fifty-Year Review

Researchers in the U.S. and India reviewed the pharmacological treatment of schizophrenia since its introduction 50 years ago, trying to understand why it "remains...

Slew of New Studies Spot Links Between Psychiatric Medications and Bone Loss, Fractures

Four different studies conducted in different ways examining different groups have linked use of certain psychiatric drugs to bone fracture risks and negative impacts on human bone development.

Antipsychotics Not Helpful for Anorexia

A review of all research on the use of antipsychotics for the treatment of anorexia nervosa found no demonstrable efficacy in terms of body...

Antipsychotic Drug Associated with Potentially Fatal Skin Rash

The US Food and Drug Administration is warning the public that the antipsychotic medication ziprasidone "is associated with a rare but serious skin reaction...

Safety Analysis Weighs Harms and Benefits of Antipsychotic Drugs

The researchers find that the drug effects for reducing psychosis are small and that treatment failure and severe side effects are common.

Smoking Cessation and Psychiatric Drugs Cause the Most Suicidal and Homicidal Reactions

The popular smoking cessation drug Chantix is the medication that most frequently makes people feel suicidal or homicidal, according to figures gathered by the...

Neuroleptic Malignant Syndrome Linked to Polypharmacy, Benzos, and Race

Research from London and Taipei finds that neuroleptic malignant syndrome (NMS) is associated with the number of different antipsychotics used (polypharmacy), rather than the overall...

Atypicals Associated with Diabetes in Adults Without Schizophrenia or Bipolar Diagnoses

Writing in Evidence Based Mental Health, researchers from Harvard Medical School and Massachusetts General Hospital found that use of medication for diabetes was significantly...

Antipsychotic-induced Sexual Dysfunction Underreported

Researchers found some antipsychotics to be worse than others for causing sexual dysfunction.

Therapy Without Drugs May Ward Off Psychosis

A double-blind, randomized, placebo-controlled study comparing outcomes from risperidone, cognitive therapy, and supportive therapy in a cohort of 115 at-risk young adults over a...

Antipsychotics Increase Risk of Heart Attack in the Elderly

In a study of 10,969 older patients treated with antipsychotics in Quebec, Canada, researchers found a 2.19 times greater risk of heart attack in...

New Research Suggests Brain Abnormalities in ‘Schizophrenia’ May Result From Antipsychotics

Study finds that reduced cortical thickness and brain surface area associated with 'schizophrenia' may result from antipsychotic drug use.

Better Recovery and Less Relapse Without Meds: A 20-Year Study

Researchers at the University of Illinois College of Medicine found, in a 20-year prospective study of 139 psychotic patients, that patients had a far...

Scientists Clarify Risks of Augmenting with Antipsychotic Medications for Depression

The researchers found that while antipsychotic drugs may be slightly more effective than alternative antidepressants, they come with a much higher side effect burden.

Scant Evidence for Combining Antipsychotics

Researchers in Barcelona, Spain retrospectively reviewed the use of antipsychotics in 117,811 patients, of whom 9,855 were given combinations of antipsychotics and 13,763 were...

Mental Health Nurses Do Not Routinely Assess for Effects of Antipsychotic Medications

Researchers believe that side-effect monitoring is critical because of the increase in the use of antipsychotics

Very Slow Taper Best for Antipsychotic Discontinuation

An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

20-Year Data Show Antipsychotics Do Not Reduce Psychosis

Martin Harrow's study tracing the effects of antipsychotics on 139 schizophrenia (SZ) and mood-disordered patients over 20 years, just published in Psychological Medicine, finds...

Less-impaired Youth Using Antipsychotics with Other Medications More Often

Use of second-generation antipsychotics (SGA) alongside other medications is growing rapidly among youth who are less impaired, according to a study published online in...

Four Leading Antipsychotics Aren’t Safe or Effective in Older Adults

A 5-year study funded by the National Institute of Mental Health and conducted by U.C. San Diego School of Medicine, Stanford University and the...

The Case Against Antipsychotics

This review of the scientific literature, stretching across six decades, makes the case that antipsychotics, over the long-term, do more harm than good. The drugs lower recovery rates and worsen functional outcomes over longer periods of time.

Increasing Use of Antipsychotics for Disruptive Behavior in Children

Canadian researchers systematically reviewed all randomized controlled trials of second-generation antipsychotics (SGAs) and placebo in the treatment of disruptive behavior disorders in children, finding...

Increased Risk of Movement Disorders From Antipsychotics in Persons with Intellectual Disabilities

Large cohort study demonstrates that those with an intellectual disability are at an increased risk for movement disorder side effects of antipsychotics.

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