Pregnancy & Birth Defects

A new study conducted in the Netherlands, published in the Journal of Psychiatric Research, investigates the effect of terminating an unwanted pregnancy on the...

There is accumulating evidence that taking SSRI antidepressants increases the risk of bleeding and other complications during surgery, according to a review published in the British Journal of Anaesthesia.

Mothers’ loss of group membership impacts their social identity and linked to postpartum depression.

This week another study was published showing that SSRI antidepressant use during pregnancy is associated with increased rates of autism in the children.  By my count, this is now the tenth study on this topic and it follows on the heels of previous studies – all of which found links between SSRI antidepressant use in pregnancy and autism in the offspring.  Most of these studies were recently reviewed by Man, et al, who also concluded that SSRI antidepressant use during pregnancy is associated with autism in the children. So we now have numerous studies in different human populations all showing a link between SSRI use in pregnancy and autism in the children. Yet, much of the news and blogosphere focus on casting doubts about these findings. What is going on here?

Between 2,150 and 4,100 children suffered from severe malformations connected to valproate prescription.

This month, the seventh study and eighth study came out on the topic of antidepressant exposure during pregnancy and autism.  And these studies showed, as essentially all of the others have, that antidepressant use during pregnancy (principally with selective serotonin reuptake inhibitors or SSRIs) is associated with autism in the exposed children. With so many children being diagnosed with autism and so many women taking antidepressants during pregnancy, everyone wants to know: are these things (the antidepressants) associated with autism or not?  Quite frankly no one has the time to read through all eight scientific papers (and dozens more animal and basic science studies) to understand this important area, so I will do my best to briefly summarize it here.

An important new research paper was published this week on the topic of antidepressant use during pregnancy and preterm birth.  The issue is a crucial one as preterm birth (i.e. birth at less than 37 weeks gestational age) is one of the most challenging problems facing the obstetrical community today.  Rates of preterm birth have been increasing over the past two decades.  Babies born early have increased risks of morbidity and mortality.  At the same time, rates of antidepressant use during pregnancy have increased dramatically.

Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.

New research published in the July issue of The Journal of Clinical Psychiatry found that the use of mood stabilizers, antipsychotics, antidepressants, and hypnotics during pregnancy is associated with increased health risks to the infant.

New research, based on data from almost a million children in Denmark, suggests that children of mothers who use antidepressants during pregnancy are more likely to be diagnosed with autism and psychiatric disorders.

Depression during pregnancy is an important issue. Depression should not be ignored and depressed pregnant women deserve good treatment and care. Part of that good care, though, is providing them with full and correct information. I care for pregnant women taking antidepressants on a daily basis and too often they tell me that the only counseling they received about the medication was, “my doctor told me it’s safe in pregnancy.” This post will review the evidence in this area and address the counterarguments.

According to the CDC, January is National Birth Defects Prevention Month. New research continues to link various SSRI antidepressants with birth defects and neurological abnormalities in newborns. The latest study to examine this topic, a meta-analysis led by Dr. Anick Bérard, found a 23% increased risk for birth defects, and a 28% increased risk for heart problems, in the infants of women who took the SSRI Paxil (paroxetine) during their first trimester.

When you take a woman who has been eating processed food, taking The Pill, antibiotics, and maybe even a PPI, exposed to xenoestrogens, endocrine disruptors, and friendly-bacteria-slaughtering pesticides and you grow a baby in that womb, there is a good chance you have created a time-bomb. Throw in 70 doses of 16 neurotoxic and immunosuppressive vaccines by age 18, some formula, and genetically modified and processed baby food, 4 years of plastic diapers, and Johnson’s 1,4-dioxane babywash and… Houston, we have a problem.

Recently, Thomas Insel, director of the National Institute of Mental Health, identified the “NIMH’s Top 10 Research Advances of 2011.” He wrote: “This has been a year of exciting discoveries and scientific progress . . . Here are 10 breakthroughs and events of 2011 that are changing the landscape of mental health research.”

When patients come to me with complaints of low libido, low or flat mood, weight gain, hair loss, and cloudy thinking, one of my first questions is “Are you on the Pill?”. When they come complaining about premenstrual irritability, insomnia, tearfulness, bloating, and breast tenderness, requesting that I sanction beginning a course of oral contraceptives and perhaps an antidepressant, the one-size-fits-all-cure-all of psychiatrists and gynecologists nationwide, my first comment is “There’s a better way.”

The Public Library of Science calls for "case studies that can help broaden our understanding of global mental health in 'real-life' contexts." The series...

This is not just about pregnancy loss and motherhood. This is reflective of how we treat many people who have experienced pain and are expressing it in ways not immediately relatable to those around them. It is about how we as a society may contribute to some of the truly awful things that happen not by failing to properly screen and assess, but by quite successfully fostering fear and alienation.

A team in the Netherlands is currently investigating the effects of tapering off of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) during pregnancy....

We know that all drugs have side effects. That’s just part of the deal right? But is it really possible that an antidepressant can cause a sane person to act like a cold-blooded criminal?

What depressed pregnant women need is compassionate care and accurate information that recognizes the potentially severe consequences of depression while making it clear that chemicals going into a baby throughout its development will likely have consequences for that development.

Nineteen defective drug product liability cases against Prizer have been filed in West Virginia state court by mothers alleging that their children suffered from...

Researchers, publishing in Toxicology Research, review the evidence that antidepressant exposure in the womb is linked to autism spectrum disorders (ASD) in humans.

A study of 228,876 pregnancies, published in the July issue of the American journal of Obstetrics & Gynecology, finds that maternal antidepressant use is...

Children who were exposed to anti-seizure drug valproate in utero were 48% more likely to develop ADHD, according to a new study.

A new study published this week in JAMA Psychiatry indicates that infants are more likely to develop speech or language disorders if they are exposed to antidepressants during pregnancy.