Saturday, January 28, 2023

The P-Value Problem in Psychiatry

17
Stanford researcher writes that readers should check the effect size of results instead of looking at the p-value.

How Dissenting Voices are Silenced in Medicine

11
Researcher criticizes the many ways opposing viewpoints and dissenting voices are squashed in the field of medicine.

Biogen Pushes FDA to Approve Failed Alzheimer’s Drug

2
A new analysis, published in Lancet Neurology, demonstrates how Biogen is spinning results from two failed trials for a new Alzheimer's drug.

Researchers Set the Record Straight on Controversial Zoloft Study

1
An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

What is the Evidence for Empirically Supported Treatments in Psychology?

11
New meta-scientific review questions the evidence for the gold standard psychotherapies and empirically supported treatments.

Statisticians: Current Policies Approve Ineffective Treatments

1
Current standards for clinical trials rely on statistical methods that allow for ineffective treatments to gain approval.

Despite Claims, EPA Supplement Does Not Improve ADHD Symptoms in Youth

8
A new study reports that the supplement EPA improved ADHD symptoms but a closer look calls these results into question.

Researchers: “Antidepressants Should Not be Used for Adults with Major Depressive Disorder”

7
A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.

Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds

10
Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.

Guidelines Recommending Antidepressants “in Contradiction with the Current Evidence”

5
Researchers critique the German S3 guidelines for depression promoting antidepressants.

Review Finds FDA Approval of Digital Antipsychotic Misguided

8
The approval of the digital antipsychotic may open the door for more pharmaceutical company profits without evidence of benefits to patients.

Positive Antidepressant Study “Misleading” and “Erroneous”

3
An analysis of last year’s positive finding in The Lancet about antidepressant efficacy shows errors, obfuscations, and misrepresentations.

Sodium Nitroprusside Shows No Efficacy in Schizophrenia Treatment

15
Researchers question biases of preliminary trials that found that sodium nitroprusside, an antihypertensive drug, has positive effects on schizophrenia symptoms.

Researchers Fail to Replicate Evidence for “Biotypes” of Depression

57
A new study casts doubt on whether such biotypes for depression exist.

The Impact of Regression to the Mean in Psychiatric Drug Studies

12
Could the statistical phenomenon of regression to the mean be responsible for the dramatic effects of placebo—as well as the supposed effectiveness of some psychiatric drugs?

Withdrawal Symptoms Routinely Confound Findings of Psychiatric Drug Studies

10
Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.

No Brain Connectivity Differences Between Autism, ADHD, and “Typical Development”

38
Neuroscience researchers find no differences in brain connectivity between children with diagnoses of autism, ADHD, and those with no diagnoses.

It is Time to Abandon the Candidate-Gene Approach to Depression

17
The candidate-gene approach to depression goes unsupported and is likely based on bad science, new research finds.

Mental Health Concerns Not “Brain Disorders,” Say Researchers

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The latest issue of the journal Behavioral and Brain Sciences features several prominent researchers arguing that mental health concerns are not “brain disorders.”

Researchers Ask, ‘Why Do Antidepressants Stop Working?’

24
An international group of researchers, including several with financial ties to manufacturers of antidepressants, explore possible explanations for why long-term users of antidepressants become chronically depressed.

Multiple Researchers Examining the Same Data Find Very Different Results

5
A new study demonstrates how the choice of statistical techniques when examining data plays a large role in scientific outcomes.

Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics

21
A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.

Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting

27
Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.

Less Than Half of Clinical Trials Comply with Legislation to Accurately Report Results

2
A new study finds that sponsors of clinical trials in the EU continue to fail at reporting their results as required by recent legislation.

Reanalysis of STAR*D Study Suggests Overestimation of Antidepressant Efficacy

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Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.