Researchers Search for Subgroups Where Antidepressants Are More Effective
The researchers theorized that this increased effectiveness was due not to “antidepressant” properties, but rather to the drug’s side effects, which include insomnia, drowsiness, and nausea.
Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption
Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.
New Study Concludes that Antidepressants are “Largely Ineffective and Potentially Harmful”
A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”
Study Finds ADHD Drugs Alter Developing Brain
A new study, published in the JAMA Psychiatry, investigates the effect of stimulant ‘ADHD’ drugs on the brains of children and young adults. The...
Mental Health Concerns Not “Brain Disorders,” Say Researchers
The latest issue of the journal Behavioral and Brain Sciences features several prominent researchers arguing that mental health concerns are not “brain disorders.”
Antidepressants Do Not Prevent Suicides, May Increase Risk
When the CDC released data revealing an increasing suicide rate in the US, some experts, speaking to major media outlets, speculated that the increase...
New Data Show Lack of Efficacy for Antidepressants
An article published this month in the journal BMC Psychiatry suggests that there is a lack of efficacy for SSRIs and that they significantly increase the risk of serious side effects.
It is Time to Abandon the Candidate-Gene Approach to Depression
The candidate-gene approach to depression goes unsupported and is likely based on bad science, new research finds.
Multiple Researchers Examining the Same Data Find Very Different Results
A new study demonstrates how the choice of statistical techniques when examining data plays a large role in scientific outcomes.
Researchers Expose Pharmaceutical Industry Misconduct and Corruption
Corruption of pharmaceutical industry sponsored clinical trials identified as a “major obstacle” facing evidence-based medicine.
Lancet Psychiatry’s Controversial ADHD Study: Errors, Criticism, and Responses
Amid calls for a retraction, Lancet Psychiatry publishes articles criticizing the original finding and a response from the authors.
No Brain Connectivity Differences Between Autism, ADHD, and “Typical Development”
Neuroscience researchers find no differences in brain connectivity between children with diagnoses of autism, ADHD, and those with no diagnoses.
The Impact of Regression to the Mean in Psychiatric Drug Studies
Could the statistical phenomenon of regression to the mean be responsible for the dramatic effects of placebo—as well as the supposed effectiveness of some psychiatric drugs?
Researchers Set the Record Straight on Controversial Zoloft Study
An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).
Interview: Researchers Deconstruct Ghostwritten Industry Trial for Antidepressant
Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.
Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting
Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.
Brain Scans Cannot Differentiate Between Mental Health Conditions
A new study analyzing over 21,000 participants found that differences in activation of brain regions in different psychological “disorders” may have been overestimated, and confirms that there is still no brain scan capable of diagnosing a mental health concern.
Two-Thirds of Schizophrenia Patients Do Not Remit on Antipsychotics
A new analysis of antipsychotic treatment of schizophrenia (published in Schizophrenia Bulletin) has found that two-thirds of patients treated this way do not experience symptom remission.
Withdrawal Symptoms Routinely Confound Findings of Psychiatric Drug Studies
Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.
A Tale of Two Studies
With increasing evidence that psychiatric drugs do more harm than good over the long term, the field of psychiatry often seems focused on sifting through the mounds of research data it has collected, eager to at last sit up and cry, here’s a shiny speck of gold! Our drugs do work! One recently published study on withdrawal of antipsychotics tells of long-term benefits. A second tells of long-term harm. Which one is convincing?
Therapy Recommended As First Line Treatment for Depression
Following an extensive systematic review of treatments for major depression, the American College of Physicians (ACP) issued a recommendation to clinicians suggesting cognitive behavioral therapy (CBT) as a first-line treatment for major depressive disorder along with second-generation antidepressants. The results of the review revealed that CBT and antidepressants have similar levels of effectiveness but that antidepressants present serious side-effects and higher relapse rates.
Researchers Fail to Replicate Evidence for “Biotypes” of Depression
A new study casts doubt on whether such biotypes for depression exist.
Rigorous Study Finds Antidepressants Worsen Long-Term Outcomes
A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.
German Psychologists Declare “the Drugs Don’t Work”
Jürgen Margraf and Silvia Schneider, both well-known psychologists at the University of Bochum in Germany, claim that psychotropic drugs are no solution to mental...
Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds
Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.
