Researchers Search for Subgroups Where Antidepressants Are More Effective
The researchers theorized that this increased effectiveness was due not to “antidepressant” properties, but rather to the drug’s side effects, which include insomnia, drowsiness, and nausea.
Antidepressants Do Not Prevent Suicides, May Increase Risk
When the CDC released data revealing an increasing suicide rate in the US, some experts, speaking to major media outlets, speculated that the increase...
Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption
Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.
Rigorous Study Finds Antidepressants Worsen Long-Term Outcomes
A new study conducted by Jeffrey Vittengl at Truman University has found that taking antidepressant medications resulted in more severe depression symptoms after nine years.
Positive Antidepressant Study “Misleading” and “Erroneous”
An analysis of last year’s positive finding in The Lancet about antidepressant efficacy shows errors, obfuscations, and misrepresentations.
Researchers Challenge Industry-Friendly Depression Guideline
Review of a new mixed depression guideline reveals financial bias of guideline developers and lack of evidence supporting recommendations for prescribing of antipsychotics.
Researcher Challenges Clinical Effectiveness of Antidepressants
A new article in BMJ Evidence-Based Medicine addresses common misinterpretations of the efficacy research on antidepressants.
Antidepressants Not Superior to Psychotherapy for Severe Depression
On Wednesday, JAMA Psychiatry released a meta-analysis comparing the results of cognitive-behavioral therapy and antidepressant medication in severely depressed populations. Currently, many practice guidelines suggest that antidepressants be used over psychotherapy for major depressive disorder. The analysis, however, found that “patients with more severe depression were no more likely to require medications to improve than patients with less severe depression.”
Outcome Reporting Bias in Antipsychotic Medication Trials
A new study in the journal Translational Psychiatry, an influential journal in biological psychiatry published by Nature, challenges the state of the research on antipsychotic drugs.
New Study Concludes that Antidepressants are “Largely Ineffective and Potentially Harmful”
A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”
No Brain Connectivity Differences Between Autism, ADHD, and “Typical Development”
Neuroscience researchers find no differences in brain connectivity between children with diagnoses of autism, ADHD, and those with no diagnoses.
Researchers Set the Record Straight on Controversial Zoloft Study
An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).
Guidelines Recommending Antidepressants “in Contradiction with the Current Evidence”
Researchers critique the German S3 guidelines for depression promoting antidepressants.
Statisticians: Current Policies Approve Ineffective Treatments
Current standards for clinical trials rely on statistical methods that allow for ineffective treatments to gain approval.
Zoloft Does Not Improve Depression, Even in Severe Cases, Study Finds
Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.
Researchers Expose Pharmaceutical Industry Misconduct and Corruption
Corruption of pharmaceutical industry sponsored clinical trials identified as a “major obstacle” facing evidence-based medicine.
Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting
Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.
Brain Scans Cannot Differentiate Between Mental Health Conditions
A new study analyzing over 21,000 participants found that differences in activation of brain regions in different psychological “disorders” may have been overestimated, and confirms that there is still no brain scan capable of diagnosing a mental health concern.
Study Finds ADHD Drugs Alter Developing Brain
A new study, published in the JAMA Psychiatry, investigates the effect of stimulant ‘ADHD’ drugs on the brains of children and young adults. The...
New York Times Issues Correction on RAISE Study Report
Last Tuesday, The New York Times and several other outlets (including Mad In America) reported on the highly-touted results of a study on psychosocial treatment for patients diagnosed with schizophrenia. Now, claims made about the study, which the ‘Times called “the most rigorous trial to date,” are coming under increased scrutiny.
Ioannidis Questions Strength of Psychology and Neuroscience Literature
Last week, well-known Stanford scientist John Ioannidis and his colleague Denes Szucs released a new analysis online. They examined research published in eighteen prominent...
Mental Health Concerns Not “Brain Disorders,” Say Researchers
The latest issue of the journal Behavioral and Brain Sciences features several prominent researchers arguing that mental health concerns are not “brain disorders.”
Lancet Psychiatry’s Controversial ADHD Study: Errors, Criticism, and Responses
Amid calls for a retraction, Lancet Psychiatry publishes articles criticizing the original finding and a response from the authors.
‘Do Antidepressants Work?’ is the Wrong Question
“This research points to the inadequacy of asking the simple question: ‘Do antidepressants work?’ Instead, the value or otherwise of antidepressants needs to be understood in the context of the diversity of experience and the particular meaning they hold in people’s lives.”
Interview: Researchers Deconstruct Ghostwritten Industry Trial for Antidepressant
Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.
