Antidepressants

Researchers find that support and self-care were helpful for users during discontinuation, but that mental health professionals were not very helpful.

Selective serotonin reuptake inhibitors (such as Prozac and Zoloft) are the most commonly prescribed medication for depression. SSRIs have long been associated with an...

In my wildest dreams, I could never have imagined being drawn into a story of intrigue involving my own government’s efforts to hide, from the public, reports of psychiatric drugs associated with cases of murder, including homicides committed by youth on the drugs. But that is precisely the intrigue I now find myself enmeshed in.

Bipolar drug therapy is a balancing act of benefits vs. harms. Odds of attributable benefit cluster in a 15-25% band, so 75%-85% don’t see substantial benefit. Stated differently, if five people take a bipolar drug, only one is likely to see substantial improvement due to it, but all five will have side effects.

Recently, I have been the target of much wooing by my local Sunovion rep. I think he leaves messages for me almost weekly and he sends me missives - glossy brochures and reprints from major psychiatric journal. What is the subject of this attention? The drug - lurasidone (Latuda).

A new study by Peter Groot and Jim van Os has found that tapering strips help people successfully discontinue antidepressant medications.

They helped me function for a while, but the debilitating side effects of antidepressants held me prisoner. I'm still having a hard time understanding how this could have happened. It's been suggested to me by a therapist that what I'm going through now is another kind of PTSD: the ongoing trauma of realizing what antidepressants did to me for 30 years.

A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.

When I first saw this Lancet 2018 network meta-analysis of antidepressant trials, my thought was that the authors had rewarded those companies that had cheated the most with their trials. My suspicion was strengthened when I looked at the results in their abstract and the three drugs they claimed were more effective and better tolerated.

A new study, published this month in the Journal of Affective Disorders, investigated the effectiveness of weekly intravenous ketamine injections as a treatment for...

Antidepressants may be effective over the short term, but research is showing that treatment resistant depression has risen dramatically in the past 30 years; evidence that the drugs may be inducing chronic depression.

Robin Williams had "therapeutic" levels of the tetra-cyclic antidepressant mirtazapine in his blood at the time of his suicide, according to the coroner's report...

Corruption of pharmaceutical industry sponsored clinical trials identified as a “major obstacle” facing evidence-based medicine.

A new study finds poorer depression and anxiety outcomes in psychotherapy for people in economically deprived neighborhoods and those on antidepressants.

An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

Journalists have called Marianne Williams’ comments on depression dangerous and irresponsible. A closer look reveals that her “opinions” on mental health treatment are more in line with the science, and that the know-it-all assertions by Cooper and colleagues are belied by it.

Researchers suggest that the pharmaceutical industry had a vested interest in using the term “discontinuation” in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.

I submitted a letter to the editor of JAMA pointing out the likely explanation for the lack of effect of sertraline. JAMA rejected my letter, as it has done many times. Explaining why psychiatric drugs don’t work is not a priority for medical journals, it seems.

Researchers compared the efficacy of antidepressants using different rating scales and found them to be no different—just slightly better than placebo, and not meeting the criteria for clinical significance.

The patient experiencing the pain of withdrawal believed that they would feel better when they stopped taking their antidepressants. After all, they’re under the care of a board-certified medical professional who has vowed to do no harm. But despite those reassurances, they find themselves in a world of hurt.

Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.

In a new study, researchers found no evidence of antidepressant group variance, which means that there's no particular group of patients who improve more than others on the drug.

The media is now reporting details about the 18-year-old who shot and killed nine and wounded many others before killing himself on July 22 in Munich. My clinical and forensic experience leads to a distinction among people who murder under the influence of psychiatric drugs. Those who kill only one or two people, or close family members, often have little or no history of mental disturbance and violent tendencies. The drug itself seems like the sole cause of the violent outburst. On the other hand, most of those who commit mass violence while taking psychiatric drugs often have a long history of mental disturbance and sometimes violence. For these people, the mental health system seems to have provoked increasing violence without recognizing the danger.

If academic psychiatry is evidence-based, why did it take two decades to recognize SSRI withdrawal as widespread and chronic among patients?

A new study, published in the journal Molecular Psychiatry, found no link between genetics and the occurrence of depressive symptoms.