Antidepressants

German psychiatrist Stefan Leucht and colleagues have produced another really important paper. The results indicate that the small differences usually found between antidepressants and placebo are far below the sort of differences that would be clinically detectable or meaningful. Leucht et al. have conducted the first thorough, systematic attempt to provide some empirical evidence about what constitutes a clinically meaningful difference in scores on depression rating scales, although the study did not set out to explore antidepressant effects.

Giovanni Fava has published an integrative analysis of the different sources of scientific research into antidepressants in Psychotherapy and Somatics. “The use of antidepressant...

Psychiatric Times has published a discussion of the research comparing the effectiveness of antidepressant medications under different conditions. “First, there seem to be no...

Thanks to the work of Dr. Irving Kirsch, we now know that the majority of the effect of antidepressants is attributable to the "active placebo effect" or the belief that receiving a memified brain-chemical-corrector will actually help alleviate symptoms. As I discuss in this post, evaluation of published and unpublished data, in two metanalysis, demonstrated a non-clinically significant difference between placebo and antidepressants. A fascinating new study entitled The Role of Patient Expectancy in Placebo and Nocebo Effects in Antidepressant Trials further explores the power of belief in psychiatric treatment.

Examining the link between depression and loss of employment, a study by American researchers in the British Journal of Psychiatry found that cognitive therapy...

The alleged “Prom day” killer, Christopher Plaskon, is a snap shot of the future result of Connecticut’s increased mental health services. The 17 year-old's defense apparently will be that his “mental health” caused his murderous actions – not the dangerous psychiatric drugs he obviously has been taking for some time.

On April 19, 2014, The Lancet published an article titled Do we underestimate the benefits of antiddepressants?, by German psychiatrists Mazda Adli and Ulrich Hegerl. The authors argue that randomized controlled trials (RCT's), as currently conducted, systematically underestimate the benefits of antidepressants and overestimate the benefits of psychotherapy. But what's interesting is that in all the years that pharma-psychiatry was churning out its fraudulent, spurious and self-serving "findings," I never heard of a single complaint from psychiatry about these kinds of methodological issues.

Greg Young, who leapt to his death from the top of Niagara Falls, "had been on numerous medications, all of which came with warnings...

The title of Edward Herman and Noam Chomsky’s book Manufacturing Consent derives from presidential advisor Walter Lippmann’s phrase “the manufacture of consent”—a necessity for Lippmann, who believed that the general public is incompetent in discerning what’s truly best for them, and so their opinion must be molded by a benevolent elite who do know what’s best for them. Why has the American public not heard psychiatrists in positions of influence on the mass media debunk the chemical imbalance theory? Big Pharma’s corruption of psychiatry is only part of the explanation. Many psychiatrists, acting in the manner of a benevolent elite, did not alert the general public because they believed that the chemical imbalance theory was a useful fiction to get patients to accept their mental illness and take their medication. In other words, the chemical imbalance theory was an excellent way to manufacture consent.

My name is Leah Harris and I'm a survivor. I am a survivor of psychiatric abuse and trauma. My parents died largely as a result of terrible psychiatric practice. Psychiatric practice that took them when they were young adults and struggling with experiences they didn’t understand. Experiences that were labeled as schizophrenia. Bipolar disorder. My parents were turned from people into permanent patients. They suffered the indignities of forced treatment. Seclusion and restraint. Forced electroshock. Involuntary outpatient commitment. And a shocking amount of disabling heavy-duty psychiatric drugs. And they died young, from a combination of the toxic effects of overmedication, and broken spirits.

Chuck Norris writes in WND: "I believe that too many who struggle with mild cases of depression don’t think they can find genuine relief...

A comprehensive meta-analysis of randomized trial data by researchers from the Harvard School of Public Health finds that children and young adults who start...

Julia Llewellyn Smith reports in the Telegraph that "Last year, 53 million prescriptions were issued for antidepressants in England alone, nearly double the number prescribed a...

"A 'tail suspension test' is exactly what its title implies. Researchers lift a rat by the tail for a few minutes at a time,...

On Monday April 14th, an important new study from Harrington et al was published in the journal Pediatrics (the official journal of the American Academy of Pediatrics.)  The study was designed to examine prenatal use of selective serotonin reuptake inhibitors (SSRIs) and the risk of autism spectrum disorders (ASDs) and other developmental delays (DDs).  Nine hundred sixty-six mother child pairs were studied and the researchers found that in boys, the association between maternal SSRI use in the first trimester and autism was very strong (OR 3.22).  The association between third-trimester maternal SSRI use and developmental delay was even stronger, with an odds ratio of 4.98.