Withdrawal Research Studies

Picture of distressed man facing pills

What Helps Long-Term Users of Benzodiazepines and Z-Drugs Discontinue?

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Current long-term users of benzodiazepines and Z-drugs identify barriers and facilitators for discontinuation.

Withdrawal Symptoms Routinely Confound Findings of Psychiatric Drug Studies

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Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.

New Study Examines Successful Discontinuation of Antipsychotics

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A new study to be published in the next issue of Schizophrenia Research examines patients suffering from a first-episode of psychosis who stop taking any antipsychotic drugs. The researchers attempt to identify variables that can serve as predictors of the successful discontinuation of antipsychotics. They find, for example, that those who discontinue the drugs have, on average, the same outcomes as those who stay on them, and that those who have better social integration are more likely to discontinue without relapse.

Service-User Knowledge Helps Researchers Develop Psychiatric Drug Tapering Approaches

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New strategies for tapering psychiatric drugs achieved by acknowledging withdrawal symptoms and valuing service-users’ first-hand knowledge.

Activity-Based Therapies Reduce Antipsychotic Use

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Researchers from the University of North Carolina found that activity-based therapy and care reduced the use of antipsychotics in a study of 107 people...

When Switching Antipsychotics, No Difference Between Immediate and Gradual Discontinuation

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Review study compares outcomes of gradual vs. immediate antipsychotic discontinuation when switching from one drug to another.

Prescribers Often Fail to Support Patients Discontinuing Antidepressants, Study Finds

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Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Antidepressant Use Climbs as Patients Find it Difficult to Discontinue

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Findings point to the role of withdrawal symptoms and prescriber practices in long-term antidepressant use.

Strategies for Tapering and Discontinuing Antidepressants

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A new review of strategies to support both patients and practitioners through the process of discontinuing antidepressants.

Benzo Discontinuation Improves Quality of Life and Reduces Symptoms of Schizophrenia

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Researchers in Japan find that tapering or reducing benzodiazepines has a positive effect on quality of life, verbal and working memory, and psychiatric symptoms...

Existential Therapy Assists Patients Withdrawing From Psychiatric Drugs

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Confronting existential anxiety through “Basal Exposure Therapy” shows promising results in people withdrawing from psychotropic drugs.

Rethinking Madness and Medication: Researcher Discusses Psychiatric Drug Withdrawal and Survivor Movements

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New understandings of medication and withdrawal experiences warrant rethinking conceptualizations of health and “madness."

Antipsychotic Drugs and Relapse

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Researchers from Germany, Greece and the U.S. reviewed the literature on relapse at 7 to 12 months following initiation of antipsychotic treatment. They conclude...

Psychiatry’s Top Experts Acknowledge Lasting Harms of Antidepressant Withdrawal

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Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

New Study Explores Approaches to Discontinuing Antidepressants

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Psychiatrist and psychologist outline pharmacological and psychotherapeutic strategies for discontinuing antidepressants.

Researchers Provide Guidance for Reducing and Stopping Psychiatric Drugs

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New guidance on how to taper and discontinue from psychiatric drugs from leading researchers Mark Horowitz and David Taylor.

Study Examines the Difficulty of Withdrawing from Antidepressant Drugs

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Correcting unnecessary long-term antidepressant use is difficult and met with apprehension by providers and service-users.

Common Statistical Method Conflates Withdrawal with Relapse

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Researchers argue that common study methods for psychiatric drugs may inadvertently minimize withdrawal effects and inflate drug efficacy.

Report Calls For Policy Changes In Response To Dependence and Withdrawal From Prescribed Drugs

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Statistics from the UK reveal that prescriptions for painkillers and antidepressants continue to rise despite concerns over dependence and debilitating withdrawal effects. The British Medical Association (BMA) Board of Science has released a report that acknowledges changes to medical practice, research and policy necessary for addressing the dependence and withdrawal effects of benzodiazepines, opioids, and antidepressants.

Social Support Improves Antipsychotic Discontinuation, Study Finds

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A new study explores how people manage to discontinue antipsychotic medication and examines how social supports may improve outcomes.

Alarming Report on Antidepressant Side Effects

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Drawing on analysis of data from websites such as Paxilprogress.org, ehealthforum.com, depression forums.org, about.com, medhelp.org, drugLib.com, topic.com and survivingantidepressants.org, researchers from the University of...

Online Experts on Withdrawal

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Online communities are stepping in to help people facing withdrawal effects amass information and receive support for their withdrawal experiences.

New Study Asks Doctors About Barriers to Deprescribing

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Researchers interviewed doctors about the barriers that prevent them from being able to decrease excess medications.
A box of Zyprexa pills.

Lack of Clear Guidelines Prevent Clinicians from Reducing Antipsychotics

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A recently published study from noted critical psychiatry expert Joanna Moncrieff explored the barriers that prevent clinicians from helping service users in discontinuing or...

FDA Safety Warning For Citalopram Did Not Improve Outcomes for Vets

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Instead of reducing risk, the dose reduction recommendation made by the FDA in their safety message was associated with an increase in hospitalizations.