Withdrawal Research Studies

Peer-Support Groups Were Right, Guidelines Were Wrong: Dr. Mark Horowitz on Tapering Off Antidepressants

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In an interview with MIA, Dr. Horowitz discusses his recent article on why tapering off antidepressants can take months or even years.
Vector of a sick sad patient man in depression drowning in medications sitting inside a bottle.

Antidepressant Withdrawal Is Common and Debilitating

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Those using antidepressants long-term were more likely to experience withdrawal and to have severe withdrawal symptoms.

Surviving Antidepressants: An Interview with Adele Framer

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That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.
Illustration of person with hand to their head, which is dissolving into squares

Post-Acute Withdrawal Syndrome (PAWS): Why Don’t We Know More About It?

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Persistent antidepressant withdrawal is a debilitating experience, but little research exists about its prevalence and treatment.

Medication-Free Treatment in Norway: A Private Hospital Takes Center Stage

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At the Hurdalsjøen Recovery Center in Norway, patients with a long history of psychiatric hospitalizations are tapering from their medications and, in a therapeutic environment that emphasizes a good diet, exercise, and asking patients "what do they want in life," are leaving their old lives as chronic patients behind.

Withdrawal from ADHD Medications

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This guide to the scientific literature on withdrawal from ADHD drugs provides a review of animal studies, withdrawal syndromes, and possible tapering protocols.
sertraline antidepressant withdrawal

Ambushed by Antidepressant Withdrawal: The Escape Story

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I’m alive. More than 30,000 veterans in the past decade alone are not. I was not warned of the risks of this drug. I was not told that once on it, I might never be able to get off it, or the nightmare that would ensue when I tried. I know millions of others were not told either.

Very Slow Taper Best for Antipsychotic Discontinuation

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An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

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A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.

Very Slow Tapering Best For Antidepressant Withdrawal

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A new article in Lancet Psychiatry finds that slower tapering of SSRIs is better for preventing antidepressant withdrawal effects.
the new yorker

The New Yorker Peers into the Psychiatric Abyss… And Loses Its Nerve

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The New Yorker's story on Laura Delano and psychiatric drug withdrawal is a glass-half-full story: It addresses a problem in psychiatry and yet hides the deeper story to be told. A story of how her recovery resulted from seeing herself within a counter-narrative that tells of the harm that psychiatry can do.

New FDA Study Shows Benzodiazepines Can Cause Long-Term Injury

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The FDA has finally acknowledged the adverse effects of benzodiazepines, the dangers of withdrawal, and that the current packaging does not sufficiently warn of these harms.

Stopping SSRI Antidepressants Can Cause Long, Intense Withdrawal Problems

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In the first systematic review of withdrawal problems that patients experience when trying to get off SSRI antidepressant medications, researchers found that withdrawing from SSRIs was comparable to trying to quit addictive benzodiazepines.

Withdrawal from Benzodiazepines

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A review of the scientific literature related to withdrawal from benzodiazepines, including studies of protracted withdrawal symptoms and risk of relapse related to tapering procedures.

Withdrawal from Antipsychotics

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A review of the scientific literature related to the withdrawal of antipsychotics: animal studies, withdrawal symptoms, tapering success rates, and consumer accounts of discontinuation.

Internet Forum for Tapering Psychiatric Drugs Provides Novel Insights

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After 15 years, the founder of SurvivingAntidepressants.org, Adele Framer, shares what she has learned about the science of withdrawing from psychiatric drugs.

Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants

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“Short and simple psychological programs can prevent people from relapsing when they stop their antidepressants.”

Study Highlights Difficulty of Antipsychotic Withdrawal

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New research finds insomnia, anxiety, and depression are common symptoms of antipsychotic withdrawal, highlighting difficulties of discontinuation.

Gradual Tapering is Most Successful for Withdrawal from Antipsychotics

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Mixed-Methods study explores the experiences of antipsychotic discontinuation among service users.

Antidepressant Withdrawal Misdiagnosed as Functional Disorder

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Adverse physiological symptoms of antidepressant withdrawal are regularly mistaken to be other problems to the detriment of the patient.

Mental Health Staff Reluctant to Support Service Users in Tapering Antipsychotics, Study Finds

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Study reveals schizophrenia patients find little support from mental health staff in reducing side effects-heavy drugs.

Tapered Antipsychotic Withdrawal Mitigates Risk of Psychotic Symptoms

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Research suggests that slowly tapering off an antipsychotic reduces the risk of withdrawal psychosis compared to abrupt discontinuation.

Study of Online Antidepressant Forums Reveals Long Lasting Withdrawal Effects

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Effects of discontinuing SSRIs and SNRIs reported on an online forum indicate significant and long-lasting withdrawal symptoms.

Listening to the Patient Voice: The Antidepressant Withdrawal Experience

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Patient advocates join with researchers and service users to present first-hand experiences of antidepressant withdrawal.

Review Documents Severe Withdrawal Effects of Psychiatric Drugs

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Researchers find that most psychiatric drugs cause severe withdrawal despite attempt s to gradually decrease the dosage.