Withdrawal Research Studies

Antidepressant Withdrawal Misdiagnosed as Functional Disorder

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Adverse physiological symptoms of antidepressant withdrawal are regularly mistaken to be other problems to the detriment of the patient.

“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Systematic Review Finds Antidepressant Withdrawal Common and Potentially Long-lasting

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Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.

The Ethics of Antipsychotic Dose Reduction and Patient Rights

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New research highlights the ethical responsibilities of clinicians in supporting patients who choose to reduce or discontinue antipsychotic medication.

Study of Online Antidepressant Forums Reveals Long Lasting Withdrawal Effects

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Effects of discontinuing SSRIs and SNRIs reported on an online forum indicate significant and long-lasting withdrawal symptoms.

Very Slow Taper Best for Antipsychotic Discontinuation

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An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

Exploring Psychiatry’s “Black Hole”: The International Institute on Psychiatric Drug Withdrawal

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When Carina Håkansson sent out an invitation for a symposium on "Pharmaceuticals: Risks and Alternatives," some of the world's top scientists, along with experts-by-experience, came from 13 countries to explore better ways to respond to people in crisis.
Correnn Stormcrow-And I Drown-Flickr

Literally Indescribable: Are Antidepressants Addictive?

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“My life was very, very good.” That’s how Michael sums up how things were for him—prior to his suffering from devastating withdrawal effects after discontinuing GlaxoSmithKline’s blockbuster drug Paxil.
Vector-style illustration depicting men and women chained to a giant pill bottle

Researchers Identify Factors to Predict Risk of Antidepressant Withdrawal

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Paroxetine, SNRIs, and MAOIs were associated with the highest risk of withdrawal, as was long duration of use and whether the person experienced withdrawal in the past.

Mental Health Staff Reluctant to Support Service Users in Tapering Antipsychotics, Study Finds

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Study reveals schizophrenia patients find little support from mental health staff in reducing side effects-heavy drugs.

Withdrawal from Antidepressants

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A review of the scientific literature related to withdrawal from antidepressants: mechanism of action; long-term effects of exposure to antidepressants; discontinuation syndromes; relapse upon discontinuation; tapering protocols.
Pattern of blue and yellow pills or tablets on a pink background. concept of medicine, pharmacy and coronavirus. copy space

SSRI Withdrawal has Social, Cognitive, and Emotional Consequences

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New research finds that the non-physical aspects of withdrawal from SSRIs are often overlooked.

Psychological Interventions Can Help When Tapering Off Antidepressants

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Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

Neuropsychological Tests Reveal Consequences of Polypharmacy

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Neuropsychological assessments reveal the cognitive, occupational, and social impact of polypharmacy in psychiatry.

Interview: Researcher Runs Trial on Antidepressant Withdrawal

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Tony Kendrick, a professor of Primary Care at the University of Southampton, has found through his research and practice that too many people are being prescribed antidepressants long-term without the information and support necessary to get off of them.

STOP or GO? Tapering Pregnant Women off of Antidepressants

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A team in the Netherlands is currently investigating the effects of tapering off of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) during pregnancy....

Facebook Groups Provide Psychiatric Drug Withdrawal Help When Doctors Don’t

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A new study looks at how online communities provide information and support for patients experiencing psychiatric drug withdrawal.
The young patient at the reception in the hospital

Patients Express Anger at Doctors’ Ignorance About Antidepressant Withdrawal Effects

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Antidepressant users share their frustrations towards a healthcare system that overprescribes but is ill-equipped to support with discontinuation and withdrawal symptoms.

SNRIs Added to the List of Drugs with Potential Withdrawal Symptoms

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New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.

Differentiation of SSRI and Benzo Dependence/Withdrawal “Not Rational”

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Researchers from the Cochrane Center and University of Copenhagen in Denmark, publishing in the May issue of Addiction, "explore the rationale for claiming that...

Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants

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“Short and simple psychological programs can prevent people from relapsing when they stop their antidepressants.”

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off Antidepressants

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Researchers interviewed people who were given medical advice to discontinue antidepressants.

5 Steps to Personalize Deprescribing Practices

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Researchers identify simple ways for clinicians to begin deprescribing conversations.

More Psychological Supports Needed to Manage Antidepressant Discontinuation

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Study reviews psychological interventions for antidepressant discontinuation.

New Study Examines User Experience of Discontinuing Psychiatric Medications

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Researchers find that support and self-care were helpful for users during discontinuation, but that mental health professionals were not very helpful.