Common Statistical Method Conflates Withdrawal with Relapse
Researchers argue that common study methods for psychiatric drugs may inadvertently minimize withdrawal effects and inflate drug efficacy.
Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial
Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.
Researchers Provide Guidance for Reducing and Stopping Psychiatric Drugs
New guidance on how to taper and discontinue from psychiatric drugs from leading researchers Mark Horowitz and David Taylor.
New Rating Tool for Tapering Antidepressants and Antipsychotics
Researchers developed a rating scale to better assess service users’ experiences tapering antidepressant and/or antipsychotic medication.
“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal
A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.
Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read
A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.
The Relapsing Peer Supervisor
Peer supervision is often silent and stigmatizing instead of including necessary, robust discussions around relapse.
What Does ‘Relapse’ Mean? Definitions Used in Antipsychotic Trials Are Unclear
Antipsychotic drugs are prescribed on the basis of trials that demonstrate a higher rate of ‘relapse’ in people who are withdrawn from these drugs compared to those who continue to take them. Yet, incredibly, there is no consensus about what ‘relapse’ means in this situation.
Relapse in Antipsychotic Drug Trials is Poorly Defined
There is a lack of consensus in the definition of ‘relapse’ across randomized controlled trials of antipsychotic maintenance treatment for schizophrenia and psychosis.
Risk of Depressive Relapse Three Times Higher After Previous Antidepressant Use
A new study found that having been prescribed an antidepressant previously was associated with an increased risk of depressive relapse.
Gradual Tapering is Most Successful for Withdrawal from Antipsychotics
Mixed-Methods study explores the experiences of antipsychotic discontinuation among service users.
Social Support Improves Antipsychotic Discontinuation, Study Finds
A new study explores how people manage to discontinue antipsychotic medication and examines how social supports may improve outcomes.
Alternative Therapies for Adolescent Depression as Effective as CBT, Study Finds
Brief psychodynamic and psychosocial interventions help maintain reduced depressive symptoms
Tapering Off Medications When “Symptoms Have Remitted”: Does That Make Sense?
While a 2-year outcome study by Wunderink, et al. has been cited as evidence that guided discontinuation of antipsychotics for people whose psychosis has remitted results in twice as much “relapse,” a not-yet-published followup of that study, extending it to 7 years using a naturalistic followup, finds that the guided discontinuation group had twice the recovery rates, and no greater overall relapse rate (with a trend toward the medication group having more relapse.)