Nancy Andreasen and colleagues explore progressive brain tissue loss associated with a diagnosis of schizophrenia in an article appearing this month in the American Journal of Psychiatry. Data drawn from 202 patients suggest that duration of relapse is associated with brain tissue loss in the frontal lobes, while antipsychotic treatment effects were diffusely distributed. The authors suggest that treatment is indicated to prevent relapse, but with care to use the lowest possible dosages.
Andreason, N., Liu, D., Ziebell, S., Vora, A., Beng-Choon, H; Article
Relapse Duration, Treatment Intensity, and Brain Tissue Loss in Schizophrenia: A Prospective Longitudinal MRI Study. American Journal of Psychiatry 170:609-615; June, 2013
Of Further Interest:
The Long-Term Effect of Schizophrenia on the Brain: Dementia Praecox? (American Journal of Psychiatry, Editorial)