Disorders

Pioneering research by mood disorder experts at Newcastle University has questioned the effectiveness of metyrapone, a drug suggested to treat depression. "Our research has...

Lawrence Diller continues his series on the uses and abuses of Adderall. "You take some Adderall, go through withdrawal, build up tolerance, take some...

“This is an article about how our education system is ruining young people’s lives. Nobody is listening to the teachers who say it, so perhaps someone will listen to me,” sixteen-year-old Orli writes in the Guardian. “Nothing is so important that it’s worth risking your health over, not even the piece of paper you get, age 16, to tell you whether or not you’re good enough.”

A woman in Texas attempted suicide while in the active group of a clinical trial for smoking-cassation drugs Chantix and Zyban, both known to...

The largest-ever meta-analysis of antidepressant trials appeared yesterday in the British Medical Journal. Researchers from the Cochrane Collaboration reviewed 70 trials (involving 18,526 subjects), to find that - counter to the initially-reported findings - antidepressants doubled the risk of suicide and aggression in subjects under 18. This risk had been misrepresented in the original study reports, the authors say, and suggest that the risks to adults may be similarly under-reported.

Public health researchers at the University of Western Australia examined the relationship between recreational arts engagement and mental well-being in the general population. The results, which have implications for policy makers as well as health practitioners, indicate that those who engage with the arts for two or more hours per week have significantly better mental well-being.

Four weeks ago, after I wrote a blog about a study that concluded there was no good evidence that antipsychotics improved long-term outcomes for people diagnosed with schizophrenia, I was cc’d on an email that had been sent to a number of “thought leaders” about what I had written. At least as I read the email, it put me into the usual pigeonhole for critics of psychiatric drugs: I apparently was globally “against” medications, and I had displayed a type of simplistic “categorical” thinking. All of this led to my having an email exchange with Allen Frances, and his laying out, in his opinion, the considerable "collateral damage" my writings had done.

“Overall, this study showed that the information and awareness campaign had almost no significant effects on the general public's attitudes toward people affected by either schizophrenia or depression,” the researchers, led by German medical sociologist Anna Makowski, wrote. “One could assume that deeply rooted convictions cannot be modified by rather time-limited and general activities targeted at the public.”

Mad In America contributor and prescription drug addiction reformer Barry Haslam has “taken his fight to the world stage by helping create an international...

A simple, one-time visit to an unfamiliar counselor resulted in my diagnosis of ADHD. That same visit started my avalanche of drug abuse. I was 19 years old when I was falsely diagnosed with ADHD, and it forever changed my life.

Writing for Huffpost, medical doctor Lawrence Diller looks at the effects of the ever increasing diagnoses for ADHD and the addiction and abuse issues...

A study published in this month’s issue of Stroke found that antidepressants may increase the risk of microbleeds in the brain. Both SSRI and SNRI antidepressants can disrupt natural clotting mechanisms and lead to increased adverse bleeding incidents and prolonged bleeding times.

In his NY Times article “A Drug to Cure Fear,” Richard Friedman noted: “It has been an article of faith in neuroscience and psychiatry that, once formed, emotional memories are permanent.” This has not been a principle of these disciplines, including clinical psychology, for many years. Consolidation-reconsolidation-extinction models have been around for some time now, applied in particular to persons suffering from traumatic memories; e.g., Holocaust survivors, war and genocide survivors, etc.

In recent months, two teams of researchers in the UK and the US published complementary findings about the epigenetic origins of schizophrenia that have scientific communities who indulge in ‘genetic conspiracy theories’ abuzz. While these results are intriguing, and no doubt involve pathbreaking research methodologies, this line of thought represents a decontextualized understanding both of the symptoms that are typically associated with schizophrenia, and their causes.

Reuters reports that a new drug for major depression failed to improve symptoms in two late-stage clinical trials sending the manufacture’s stock into a...

A study out of the University of Buffalo explores the use of Narrative Exposure Therapy to treat youth PTSD and substance abuse. “Trauma is...

Plaintiffs allege that Bristol-Myers Squibb and Otsuka Pharmaceutical failed to warn doctors and patients about the risk for compulsive behaviors when taking the atypical...

Writing for the Harvard Health Blog, Dr. Nandinia Mani reconsiders the use of antidepressants in teens in light of the reanalysis of Study 329. ...

According to new research by Joanna Moncrieff and Sebastião Viola, mental health problems have become the leading cause of disability claims in the UK. While the overall number of claims for other conditions has decreased by 35%, claims related to “mental disorders” have increased 103% since 1995.

Medical News Today provides an overview of the research on the effects of shift work on the physical and mental well-being of employees. "Although...

The warning label for the antidepressant Cymbalta downplayed the risks of withdrawal effects, according to consumer lawsuits being filed in courts across the country. “An estimated 44% to 78% of people who stop taking Cymbalta (also known as duloxetine) will suffer from withdrawal reactions,” yet the warning label “suggests the risk is greater than or equal to 1%.”

Nora Volkow, the director of the National Institute on Drug Abuse (NIDA), authored an editorial for BMJ this month warning that the opioid abuse epidemic could have dangerous consequences for pregnant women. While the effects of opioid exposure on the developing brain are yet unknown, research suggests that infants may suffer from withdrawal syndrome, nervous system defects, and impaired attachment with the mother.

“Children from poorer families are more likely to experience changes in brain connectivity that put them at higher risk of depression, compared with children from more affluent families,” according to new research covered by Medical News Today. "Poverty doesn't put a child on a predetermined trajectory, but it behooves us to remember that adverse experiences early in life are influencing the development and function of the brain. And if we hope to intervene, we need to do it early so that we can help shift children onto the best possible developmental trajectories."

In this month’s issue of Psychological Medicine, researchers from King’s College London found evidence for associations between different types of childhood adversity and specific symptoms associated with psychosis. As current categorical approaches to psychosis and schizophrenia diagnoses come under increasing scrutiny, this study adds support to sociological and psychological theories and treatments.

The Boston Globe reports on the discovery of a newly recognized neurological disease, anti-NMDA receptor encephalitis. The disease is believed to be caused when the body’s immune system attacks proteins in the brain associated with the communication of neurons.