Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse
A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.
Tapered Antipsychotic Withdrawal Mitigates Risk of Psychotic Symptoms
Research suggests that slowly tapering off an antipsychotic reduces the risk of withdrawal psychosis compared to abrupt discontinuation.
SNRIs Added to the List of Drugs with Potential Withdrawal Symptoms
New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.
Antipsychotic Dose Reduction Linked To Long-term Improvements In First-Episode Schizophrenia Patients
Careful reductions in dosage levels of antipsychotic medications over time improved long-term rates of recovery and functional remission in patients diagnosed with a first-episode psychosis.
Prescribers Often Fail to Support Patients Discontinuing Antidepressants, Study Finds
Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.
Cochrane Review Calls for More Research on Antidepressant Withdrawal
Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.
Differentiation of SSRI and Benzo Dependence/Withdrawal “Not Rational”
Researchers from the Cochrane Center and University of Copenhagen in Denmark, publishing in the May issue of Addiction, "explore the rationale for claiming that...
Many Service Users Interested in Decreasing Antipsychotic Use with Professional Help
New research examines service user attitudes on discontinuing and reducing antipsychotic drugs.
“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity
Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.
Antidepressants Actually Reduce Serotonin Levels
Common scientific beliefs about serotonin levels in depression and how antidepressants act on the brain appear to be completely backwards.
Withdrawal Symptoms Routinely Confound Findings of Psychiatric Drug Studies
Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.
Over One Thousand Boys Grew Breasts “Probably” Caused By Common Psychiatric Medication
According to an ex-chief of the FDA, Johnson & Johnson knew long before it started warning people that Risperdal could cause boys to grow breasts.
Psychological Interventions Can Help When Tapering Off Antidepressants
Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.
Common Side Effects Leading to Antidepressant Discontinuation
New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.
Major Risks from Drug Interactions in Common Psychiatric Polypharmacy
It is very common for psychiatric patients, especially those diagnosed with schizophrenia, to be prescribed two or more psychiatric medications at once, and this...
Prescribing Benzodiazepines As-Needed Leads to Abuse
A new study reported on in Medscape, examined risk factors for misuse of benzodiazepines (drugs such as Xanax, Ativan, and Klonopin). The researchers found that patients who had been prescribed the medication on an as-needed basis were more likely to end up abusing it than those who had been prescribed a standing dose.
Autism, Antidepressants, and Pregnancy: The Basics
This month, the seventh study and eighth study came out on the topic of antidepressant exposure during pregnancy and autism. And these studies showed, as essentially all of the others have, that antidepressant use during pregnancy (principally with selective serotonin reuptake inhibitors or SSRIs) is associated with autism in the exposed children. With so many children being diagnosed with autism and so many women taking antidepressants during pregnancy, everyone wants to know: are these things (the antidepressants) associated with autism or not? Quite frankly no one has the time to read through all eight scientific papers (and dozens more animal and basic science studies) to understand this important area, so I will do my best to briefly summarize it here.
Lithium May Cause Sexual Dysfunction — More Research Needed
Lithium appears to reduce libido and sexual function, and more research into the problem is needed.
How Providers Can Support Psychiatric Drug Discontinuation
Supportive patient-practitioner relationships are crucial to the successful discontinuation of psychiatric medication.
Cognitive Function Improved by Reducing Antipsychotics
A 28-week randomized controlled study by researchers in Japan, Canada and the United States finds that a 50% reduction of risperidone or olanzapine significantly...
New Study Examines User Experience of Discontinuing Psychiatric Medications
Researchers find that support and self-care were helpful for users during discontinuation, but that mental health professionals were not very helpful.
Thoughtful Insight, Not Lack of It, Drives Some Patients to Quit Psychiatric Medications
Rather than a "lack of insight," it is actually a thoughtful weighing of complex risks and benefits that ultimately drives some people diagnosed with bipolar disorder to eschew psychiatric medications, according to a qualitative study in the Journal of Affective Disorders. And these people often develop sophisticated strategies in their efforts to manage without medications.
Opioid Use in Pregnancy Dangerous and Understudied
Nora Volkow, the director of the National Institute on Drug Abuse (NIDA), authored an editorial for BMJ this month warning that the opioid abuse epidemic could have dangerous consequences for pregnant women. While the effects of opioid exposure on the developing brain are yet unknown, research suggests that infants may suffer from withdrawal syndrome, nervous system defects, and impaired attachment with the mother.
Children on Antipsychotics 50% More Likely to Develop Diabetes
Antipsychotic drugs increased the risk of children developing diabetes by 50%, and with an antidepressant added, their risk doubled.
What Do Antidepressants in Drinking Water Do to Birds?
Ever higher levels of pharmaceutical drugs are turning up in drinking water supplies, and an op-ed in the UK Mirror discusses a study that...