“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

Antidepressant Caused Six-fold Artery Plaque Build-up in Monkeys

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Zoloft caused up to six-fold increases in build-up of atherosclerosis plaque in the coronary arteries of monkeys.

Researchers Provide Guidance for Reducing and Stopping Psychiatric Drugs

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New guidance on how to taper and discontinue from psychiatric drugs from leading researchers Mark Horowitz and David Taylor.

Lack of Guidance Available for Discontinuing Psychiatric Drugs

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A new article discusses the lack of research dedicated to discontinuing psychiatric drugs and reviews existing strategies.

Common Benzodiazepine Sedatives May Induce Aggression

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Benzodiazepine medications that are commonly used for calming or sedating people can sometimes apparently cause violent or aggressive responses in some people, according to...
Doctor welcoming a patient

How Providers Can Support Psychiatric Drug Discontinuation

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Supportive patient-practitioner relationships are crucial to the successful discontinuation of psychiatric medication.

No Good Evidence That Antidepressants Prevent Relapse

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Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read

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A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.

Semen Abnormalities Associated with SSRI Antidepressants

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The French non-profit organization Prescrire has produced a special report about the impacts of SSRI antidepressants on male fertility.

Some Antidepressants Worse than Others for Causing Sexual Dysfunction

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In a review of the scientific evidence about sexual dysfunction caused by antidepressants, Australian researchers determined that some of the medications are worse than...

Autism Linked to Antidepressants During Pregancy

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A study of the Swedish medical birth registry, conducted by researchers from Sweden, the U.K., and the U.S.A., found a 3.3X greater risk of...

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

Adverse Emotional and Interpersonal Effects of Antidepressants

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Adverse effects of antidepressants, including sexual difficulties and emotional numbing, apathy, suicidality and withdrawal effects may be more frequent than previously reported, according to...

New Clinical Guidelines on Deprescribing Benzodiazepines

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New guidelines recommend deprescribing benzodiazepine receptor agonists for adults.

New Study Examines Successful Discontinuation of Antipsychotics

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A new study to be published in the next issue of Schizophrenia Research examines patients suffering from a first-episode of psychosis who stop taking any antipsychotic drugs. The researchers attempt to identify variables that can serve as predictors of the successful discontinuation of antipsychotics. They find, for example, that those who discontinue the drugs have, on average, the same outcomes as those who stay on them, and that those who have better social integration are more likely to discontinue without relapse.

Lithium May Cause Sexual Dysfunction — More Research Needed

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Lithium appears to reduce libido and sexual function, and more research into the problem is needed.

Benzos Fail to Prevent, May Increase PTSD

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In a review of the evidence regarding benzodiazepines, researchers from the University of Michigan find that benzodiazepines used in the treatment of PTSD are...

Over One Thousand Boys Grew Breasts “Probably” Caused By Common Psychiatric Medication

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According to an ex-chief of the FDA, Johnson & Johnson knew long before it started warning people that Risperdal could cause boys to grow breasts.

More Evidence Antidepressants Might Induce Sexual Dysfunction Even After Stopping Them

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A retrospective study in the Journal of Clinical Psychiatry examined cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants.

PTSD and Antidepressants Linked to Diabetes

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A JAMA Psychiatry study found links between PTSD, type 2 diabetes, and antidepressants.

“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity

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Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.

Major Risks from Drug Interactions in Common Psychiatric Polypharmacy

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It is very common for psychiatric patients, especially those diagnosed with schizophrenia, to be prescribed two or more psychiatric medications at once, and this...

Psychiatric Medication Use Associated with Triple the Risk of Stroke

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Common psychiatric medications double the risk of heart attack and triple the risk of stroke, according to research presented at the Canadian Cardiovascular Congress...

Evidence Lacking for Antidepressant Safety in Nursing Mothers

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A scientific review says we need to know much more about the risks of nursing mothers taking SSRIs.

African American and Hispanic Youth Discontinue ADHD Treatment at Higher Rates than White Youth

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Study examines racial and ethnic disparities in the quality of care for Medicaid-enrolled children starting ADHD medication.