Tag: Depression

Adding Antipsychotics Worsens Outcomes in Psychotic Depression

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Outcomes were worse for all, with young people on combination therapy twice as likely to experience rehospitalization or death by suicide than those on antidepressants alone.

Words from My Heart to ‘My Heart’: What Might Have Helped...

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More than two and a half years later, Iā€™m still processing my grief, still picturing our happiness and innocence as kids, and still acknowledging our struggles and pain.

Antidepressants Increase Suicide Attempts in Youth; No Preventative Effect

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Researchers find that SSRIs increase suicide attempts up to age 24, and have no preventative effect at any age, even for those at high risk of suicide.

No Benefit for Adding Antidepressants to CBT in Severe Depression

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For those with severe depression, inpatient CBT was effective but the adding antidepressants did not improve treatment outcomes.

New Data Reveal the Full Extent of STAR*D Failure

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The initial study, which has been used to promote antidepressants, employed outcome switching to hide poor results.

Antidepressants, Antipsychotics, and Benzos All Increase Suicide Attempts in New Study

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In a study of people with borderline personality disorder, only ADHD stimulants were associated with a decrease in suicide.

No Difference in Antidepressant Effectiveness After Genetic Testing

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Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.

Study Highlights Lack of Evidence for Antidepressants in Treatment of Chronic...

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A new Cochrane review details the lack of evidence for antidepressants in the treatment of chronic pain.

Alarming Overprescription Patterns for Older Adults on Antidepressants

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New study finds polypharmacy for 73% of older adults on antidepressants, with 56% at risk of harmful drug interactions.

No Link Between Serotonin and Depression: What Does That Mean for...

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Peter Simons covers in detail a new systematic review that debunks the widely popularized myth of low serotonin in depression, the ā€œchemical imbalance theory.ā€

Dying to Stay Alive: A Ketamine Disaster

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Ketamine treatment, which was being hailed as a ā€˜miracle cureā€™, backfired so spectacularly that it very nearly cost me my life.

Shifting Away from ECT and Antidepressants for Depression

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Researchers argue that we need a paradigm shift away from the biomedical model of mental illness to one informed by political action and common sense.

SSRI Antidepressants Do Not Improve Depression After a Stroke

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A study in JAMA Neurology finds that antidepressants do not reduce depression symptoms more than placebo in patients recovering from a stroke.

Psychotherapy Has an Enduring Effect on Depressionā€”in Contrast to Depression Pills

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A meta-analysis published last month showed that psychotherapy has an enduring effect on depressionā€”in contrast to depression pills.

Garbage in, Garbage out: The Newest Cochrane Meta-Analysis of Depression Pills...

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In May 2021, Cochrane published a network meta-analysis of depression pills for children. The abstract is misleading and reads like drug company marketing.

Researchers Propose Study to Test Whether Antidepressants Impede Recovery

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Evolutionary theorists suggest that antidepressants interfere with the adaptive function of depression and propose a test of this theory.

Four Essential Studies on Antidepressant Withdrawal Every Prescriber Must Read

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A researcher and service user Stevie Lewis recounts her own experience with antidepressant withdrawal and what she wishes her doctors knew.

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

New Research Questions Safety of Esketamine for Depression

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An analysis of FDA adverse event reports related to esketamine shows the potential for negative effects such as suicidal and self-injurious ideation.

Grief and Its Potential Lessons

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Within the current mental health paradigm, profound grief is often shoved into the universal category of depression and treated as a malfunction according to the biomedical model.

Dr. Pies:Ā Still Going Wrong

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In his attacks against the British Psychological Society's report "Understanding Depression," Dr. Pies falls into his own trap: "There are none so blind as those who will not see."

Insane Medicine, Chapter 5: The Manufacture of Childhood Depression (Part 2)

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The promotion of SSRI antidepressant use began with the pharmaceutical industry and occurs despite evidence that these drugs are harmful, not helpful, in children and adolescents.

Insane Medicine, Chapter 5: The Manufacture of Childhood Depression (Part 1)

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The medicalisation of our emotional lives has led to a horrific cultural shift in which we, and our children, have become alienated from and suspicious of our emotions, chipping away at our natural resilience.

Promising Preliminary Results from a Small Study of Psilocybin-Assisted Therapy

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A new study offers promising results for psilocybin-assisted psychotherapy for depression.

Not Just Another Stain on the Wall

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During my 96-hour hold in the psych unitā€”despite that I was rational and a danger to no oneā€”I was made to feel ashamed and somehow unclean. I went home feeling more depressed than ever.