Adverse Effects

Two patients have now died while taking the drug beloranib in an obesity drug trial. Both patients were in the active arm of the study and had received the drug rather than a placebo. Zafgen did not say whether it believed the drug had caused the blood clotting in the lungs that led to the patient’s death.

The authors of a large scale well-conducted systematic review of methylphenidate, also known as Ritalin, conclude that there is a lack of quality evidence for the drug’s effectiveness. Their research also revealed that Ritalin can cause sleep problems and decreased appetite in children.

Drug makers have faced large fines for unethical and harmful practices but have simply treated these as a cost of doing business. Ed Silverman reports...

Ed Silverman reports that only 80 prescriptions for Addyi, or Flibanserin, were filled in the drugs’ first two weeks on the market. Article →

A review of treatment guidelines published in Psychotherapy and Psychosomatics found that guidelines “shy away from stating clearly that SSRIs/SNRIs, like BDZs, are often (though...

The abuse of ADHD drugs on college campuses has reached epidemic proportions, according to the authors of a recent review in the journal of Ethical Human Psychology and Psychiatry. ADHD drugs, like Ritalin and Adderall, have become so commonplace on college campuses that students abusing these drugs for studying, weight loss and partying have underestimated their risks. As a result, we have seen exponential increases in emergency room visits, overdoses, and suicides by students taking these drugs.

“In America, medication is becoming almost as much a staple of childhood as Disney and McDonald’s,” writes Sarah Boseley in the Guardian. In this piece photographer Baptiste Lignel follows six boys and girls to examine the long-term effects of these drugs.

Children diagnosed with ADHD who are prescribed stimulant drugs have more sleep problems than those with ADHD that do not take these drugs.

Peter Holley reports for the Washington Post that a powerfuland highly addictive amphetamine drug known as fenethylline or Captagon is being used to fuel ISIS fighters in Syria and Iraq. “Captagon has been around in the West since the 1960s, when it was given to people suffering from hyperactivity, narcolepsy, and depression.”

More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.

In an open letter to all US presidential candidates published Thursday in the BMJ, a group of global health care experts assert that current research regulations allow drug companies to publish incomplete and misleading results. They ask the candidates to declare whether they support improved transparency measures that would make data on drug studies publically available and open to scrutiny.

Despite the promises of two successive governments to end forced shock treatment in Ireland, unwilling patients are still being forced to undergo the therapy, according to the Sunday Independent. “Writer Ernest Hemingway, who committed suicide shortly after ECT, is reported to have said before his death: ‘It was a brilliant cure but we lost the patient.’"

In 20 years of inpatient hospitalization, the psychiatrists that I encountered focused almost exclusively on treating my diseased mind and had no concept or interest in the body. While the wheels of “progress” turn slowly in mental health, I hope that along with ongoing advocacy there will be a focus on responsible health counseling and supporting people in healthier eating and living.

Infants exposed to SSRIs and benzodiazepines during pregnancy show impaired neurologic functioning in the first month after birth, according to a new study published in the American Journal of Psychiatry. While infants exposed SSRIs alone showed neurobehavioral effects throughout the first month, those exposed to an SSRI and a benzodiazepine had more significant problems.

In the third major verdict of its kind, drug giant Johnson & Johnson was ordered to pay a Maryland man who grew female breasts while taking the antipsychotic Risperdal. The company failed to warn doctors, patients, and regulators of the risk of abnormal breast development in young males and now faces about 5,400 lawsuits involving the drug.

New York Times columnist, Nicholas Kristof, relates the story of Andrew Francesco, a boy who began taking Ritalin at age five and died from complications with Seroquel when he was fifteen. His father, a former pharmaceutical industry executive, reveals the industry’s greed in his memoir “Overmedicated and Undertreated.” Now the industry is pushing for a first-amendment right to market its drugs for off-label uses.

In 2014, then National Institute of Mental Health (NIMH) director, Thomas Insel, speculated that ketamine “might be the most important breakthrough in antidepressant treatment in decades.” A recent review of the research suggests that while ketamine may produce a rapid short-term improvement in depression, the effect is short-lived and the potential for addiction and dependence warrants considerable caution.

I was a psychiatrist who participated in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE ETP). Although I welcomed the positive headlines that heralded the study's results, the reports left me with mixed feelings. What happened to render the notion that talking to people about their experiences and helping them find jobs or go back to school is something novel?

The percentage of seniors in the United States prescribed potentially deadly antipsychotic drugs increases with age. A new study reveals that in the face of serious risks of strokes, fractures, kidney injuries, and death, over seventy-five percent of seniors given antipsychotics do not have a diagnosis for a mental disorder.

Despite safety concerns, a new study reveals that there has been no change in the use of benzodiazepines in the elderly from 2001 to 2010.

In a bellwether case, plaintiffs allege that Pfizer did not adequately warn patients that Zoloft (sertraline) would cause birth defects. The case is scheduled in Federal Court in March, and the verdict will have significant implications for future suits.

The UK Times reports that pharmaceutical companies are actively lobbying to limit the release of clinical trial data to the public. Rather than limiting results and data to medical journals, new transparency initiatives are pushing for making the information publically available. The push for transparency comes in the wake of the reanalysis of the Study 329 data on paroxetine (marketed as Seroxat and Paxil), which found that the industry study had misconstrued its results.

Writing for the conservative website The New American, C. Mitchell Shaw reports that more and more evidence is pointing to psychiatric drugs as a potential cause of mass shootings. “Of course anecdotes are not proof, and most people who regularly take antidepressants do so without becoming violent,” but, he adds, it appears “that young people are particularly at risk of developing violent tendencies, suicidal tendencies, or both while taking these drugs.”

A massive number of meta-analyses of antidepressant clinical trials have financial conflicts of interest and are unduly influenced by pharmaceutical companies, according to a review to be published in an upcoming issue of the Journal of Clinical Epidemiology. Researchers also found that meta-analyses with industry ties almost never report any negative findings in their abstracts.

ITV features and article and video today about the widespread problem of addiction and withdrawal from benzodiazepine drugs used to treat anxiety, including Ativan, Librium, Diazepam and Temazepam. Mother of three Sandra Minshull shares her story and discusses how Ativan “robbed her of her life.”