Hi Lynne, This was an interesting article. I would view personal feelings about medications more in terms of expectancy and placebo effects, and less in terms of spirituality – but that is partly because I am agnostic and spirituality is not very important for me personally. I certainly think that how the person conceives of medication itself, and what they expect that it will do, is extremely powerful psychologically, often more powerful than the drug itself (this certainly seems to be the case for antidepressants, the effects of which are up to 80% a placebo and not a “real” drug effect, in terms of reducing distress, according to Kirsch). Another powerful dynamic is whether person believes the drug is “treating an illness” (i.e. whether they fit the pill into the framework of the disease model) or whether the person sees the drug as exerting a generalized damping effect on their mind/ability to feel, but not as treating any biogenetic disease. I suspect that the latter is less common than the former, given the way that psychiatrists and drug companies routinely mislead people to believe that their problems in living are brain diseases. Thus, and strangely, one could posit that many people think in a somewhat delusional way about medication – i.e. believing it to be treating a biogenetic disease they have (e.g. correcting a chemical imbalance)… rather than perceiving accurately that it is simply a nonspecific chemical compound inhibiting their general ability to feel and think as lucidly. I believe one could also say some similar things about spirituality and religiosity (i.e. that they are delusions), since I believe that these beliefs are basically denials of the fact that we are as far as we know alone in the universe (without a known God), that there is not necessarily meaning or order or intent in the universe, and that there may not be anything at all after death. Although, they are often adaptive delusions, since one feels safer and less afraid of death and meaninglessness by believing in God or being spiritual. After writing this, I realize that it is depressing not to be spiritual; however, I do not view deluding oneself with unevidenced beliefs as something to be proud of and thus it is difficult for me to be spiritual, even though I love nature and other people. This reminds me that depressed people often perceive the world more realistically than those who are more well emotionally. Anyway, I have digressed but thank you for stimulating my thinking with your article.