Sunday, February 5, 2023

Tag: antidepressants and children

Collateral Damage: The Negative Impact of Antidepressants on New Zealand Youth

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Health and wellbeing in young people are trending down in New Zealand. Are antidepressants to blame?

Garbage in, Garbage out: The Newest Cochrane Meta-Analysis of Depression Pills...

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In May 2021, Cochrane published a network meta-analysis of depression pills for children. The abstract is misleading and reads like drug company marketing.

National Boards of Health Are Unresponsive to Children Driven to Suicide...

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Peter C. Gøtzsche reports what happened, or rather did not happen, when he contacted National Boards of Health in eight countries with his serious concern that the use of depression pills in children is increasing and leads to more suicides. The continued official denial that these drugs cause suicide and that something substantial needs to be done is appalling.

Letter to My Child’s Psychiatrist

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Dear Doctor, I wonder if you remember my son... you only spent about ten minutes with him, exactly four days after his first suicide attempt. I asked you if his medication, Zoloft, had anything to do with what was happening. You looked at me and said, "There's no way of knowing; there are too many factors involved."

Adolescent Suicide and The Black Box Warning: STAT Gets It All...

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STAT recently published an opinion piece arguing that the black box warning on antidepressants has led to an increase in adolescent suicide. It is easily debunked, and reveals once again how our society is regularly misled about research findings related to psychiatric drugs. STAT has lent its good name to a false story that, unfortunately, will resonate loudly with the public.

Antidepressant Prescriptions for Children on the Rise

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From BBC News: The number of antidepressants prescribed to children in England, Scotland and Northern Ireland has risen over the past three years, figures...

The Forced Psychiatric Treatment of a Child

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This is my story of forced psychiatric treatment as an eight-year-old girl, from my perspective as an adult mental health professional. Being held down kicking and screaming to be injected with a benzodiazepine is a human rights violation no child should endure for saying no to a pharmaceutical. In hindsight, when I reflect on that day, it feels like a form of child abuse.

Usage of Depression Pills Almost Halved Among Children in Denmark

After a number of years with a steadily increasing sales curve, the number of children and adolescents in treatment with depression pills decreased by 41% in Denmark. Despite this welcome development, pharmaceutical companies and psychiatry professors continue to deceive the population and deny the facts about these drugs.

Is Society or Psychiatry to Blame for the “Seriously Mentally Ill”...

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Adults in the U.S. diagnosed with “serious mental illness” die on average 25 years earlier than others. This is not controversial, as establishment psychiatry and its critics agree. What is controversial is who is to blame?

What’s the Harm in Taking an Antidepressant?

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We know that all drugs have side effects. That’s just part of the deal right? But is it really possible that an antidepressant can cause a sane person to act like a cold-blooded criminal?

Study 329 Taper Phase

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Most doctors still affect surprise at the idea SSRIs might come with withdrawal problems. Regulators knew very clearly since 2002 about the problems, but have decided to leave any communication of these issues in company hands.

Study 329 Continuation Phase

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All the fuss about Study 329 centers on its 8-week acute phase. But this study had a 24-week Continuation Phase that has never been published. Until Now.

Prescribing Antidepressants for Girls: Intergenerational Adverse Consequences

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Children exposed to SSRIs during pregnancy, a recent study shows, were diagnosed with depression by age 14 at more than four times the rate of children whose mothers were diagnosed with a psychiatric disorder but did not take the medication. Such reports are usually met, appropriately, with an outpouring of reassurances from clinicians who take care of pregnant women, who need to protect their emotional wellbeing in whatever way they can. From my perspective as a pediatrician specializing in early childhood mental health our attention must be on prevention.

“The Hidden Harms of Antidepressants”

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In a new article for Scientific American, Diana Kwon reports on how the true risks for suicide and aggression in children and teens taking...

“Bullied Children Need Support Not Antidepressants”

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Nick Harrop, a campaign manager at YoungMinds, supporting young people’s mental health and wellbeing, said antidepressants for children should never be the only course of action....

Restoring Study 329: Letter to BMJ

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When we set out to restore GSK’s misreported Study 329 of paroxetine for adolescent depression under the RIAT initiative, we had no idea of the magnitude of the task we were undertaking. After almost a year, we were relieved to finally complete a draft and submit it to the BMJ, who had earlier indicated an interest in publishing our restoration. But that was the beginning of another year of peer review that we believed went beyond enhancing our paper and became rather an interrogation of our honesty and integrity. Frankly, we were offended that our work was subject to such checks when papers submitted by pharmaceutical companies with fraud convictions are not.

GSK to Face Class Action over Antidepressants for Children

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A Sydney, Australia law firm has launched a class action on behalf of people who as children and adolescents were prescribed Glaxosmithkline's drug Paroxetine. Despite...

Antidepressants, Pregnancy, and Autism: Why Wouldn’t Antidepressant Chemicals Affect a Developing...

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This week another study was published showing that SSRI antidepressant use during pregnancy is associated with increased rates of autism in the children.  By my count, this is now the tenth study on this topic and it follows on the heels of previous studies – all of which found links between SSRI antidepressant use in pregnancy and autism in the offspring.  Most of these studies were recently reviewed by Man, et al, who also concluded that SSRI antidepressant use during pregnancy is associated with autism in the children. So we now have numerous studies in different human populations all showing a link between SSRI use in pregnancy and autism in the children. Yet, much of the news and blogosphere focus on casting doubts about these findings. What is going on here?

After the Black-Box: Majority of Children Starting SSRIs Still Receiving Too...

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In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.

Study 329: 50 Shades of Gray

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Access to data is more important than access to information about conflicts of interest. It is only when there is access to the data that we can see if interests are conflicting and take that into account. Problems don’t get solved unless someone is motivated for some reason. We need the bias that pharmaceutical companies bring to bear in their defense of a product, along with the bias of those who might have been injured by a treatment. Both of these biases can distort the picture but it’s when people with differing points of view agree on what is right in front of their noses that we can begin to have some confidence about what we have.

Study 329 in Japan

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By 2002 GlaxoSmithKline had done 3 studies in children who were depressed and described all three to FDA as negative.  As an old post on Bob Fiddaman’s blog reproduced here outlines, several years later they undertook another study in children in Japan. (Editor's note: This is a re-print, by David Healy, of a post by Bob Fiddaman)