Tuesday, August 9, 2022

Pharmaceutical Industry Gifts Linked to Costlier Prescribing Practices

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New study finds that pharmaceutical industry gifts to medical providers in Washington D.C. are associated with higher cost, higher volume prescribing behavior.

New Study Casts Doubt on Efficacy of Ketamine for Depression

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A new study, published this month in the Journal of Affective Disorders, investigated the effectiveness of weekly intravenous ketamine injections as a treatment for...

Scientists Call for Increased Transparency in Research

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Scientists at the Yale Collaboration for Research Integrity and Transparency (CRIT) published a new policy paper this month criticizing the current state of biomedical research and calling for improved transparency in research methods.

Despite Increase in Treatments, Prevalence of Mental Health Issues Climbs

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Findings show that despite increases in treatment availability, the prevalence of mental health issues has not decreased.

“The Hidden Harms of Antidepressants”

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In a new article for Scientific American, Diana Kwon reports on how the true risks for suicide and aggression in children and teens taking...

Most Direct-to-Consumer Drug Advertisements Do Not Adhere to FDA Guidelines

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Few DTC drug advertisements fully adhere to FDA guidelines, the overall quality of information provided in DTC advertisements is low, and some advertisements market off-label indications.

“European Regulator Recommends Suspending Numerous Drugs Over Clinical Trial Problems”

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Pharmalot’s Ed Silverman reports that a number of generic drugs, sold by Novartis and Teva Pharmaceuticals, may be pulled off of the shelves after...

Very Slow Tapering Best For Antidepressant Withdrawal

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A new article in Lancet Psychiatry finds that slower tapering of SSRIs is better for preventing antidepressant withdrawal effects.

FDA: Antidepressant Trials Have Not Adequately Reported Sexual Dysfunction Side Effects

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US Food and Drug Administration scientists want to better evaluate side effects of sexual dysfunction associated with antidepressant drugs.

New Medications Fail to Show Efficacy for Alzheimer’s Disease

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Three phase III clinical trials assessing the efficacy of Lundbeck’s investigational drug idalopirdine for Alzheimer’s disease have failed

Majority of Pediatric Antidepressant Industry Trials Considered Low Quality

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Meta-analyses including studies that detail these trials could be presenting misleading information.

Clinical Trials Show Antidepressants “Not Beneficial in the Long Term”

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Clinical trials also consistently fail to measure and report long-term harmful effects.

Landmark Schizophrenia Study Recommends More Therapy

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Results of a large government-funded study call into question current drug heavy approaches to treating people diagnosed with schizophrenia. The study, which the New York Times called “by far the most rigorous trial to date conducted in the United States,” found that patients who received smaller doses of antipsychotic drugs with individual talk therapy, family training, and support for employment and education had a greater reduction in symptoms as well as increases in quality of life, and participation in work and school than those receiving the current standard of care.

Sodium Nitroprusside Shows No Efficacy in Schizophrenia Treatment

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Researchers question biases of preliminary trials that found that sodium nitroprusside, an antihypertensive drug, has positive effects on schizophrenia symptoms.

Antidepressant Misinformation Promoted on Popular Websites

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A new study indicates that popular online resources do not accurately present the scientific evidence on the risks and benefits of antidepressants.

“Many Antidepressant Studies Found Tainted by Pharma Company Influence”

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The Scientific American reports on a new analysis of antidepressant trials revealing that the vast majority of meta-analyses have industry links and suppress negative results.

New Data Supports Acupuncture as a Treatment for Depression

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Researchers found acupuncture effective in the treatment of chronic pain and depression

Study Suggests Long-Term Antipsychotic Use May Result in Poorer Cognitive Functioning

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Association found between long-term antipsychotic use and poorer performance on cognitive tasks in adults diagnosed with ‘schizophrenia.’

Neuropsychological Tests Reveal Consequences of Polypharmacy

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Neuropsychological assessments reveal the cognitive, occupational, and social impact of polypharmacy in psychiatry.

How the News Frames the Opioid Epidemic

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US news coverage has primarily framed the opioid drug abuse epidemic as a criminal justice issue rather than a public health problem, according to new research published ahead of print in the Journal of Psychiatric Services. The media’s framing of the epidemic may increase stigma against those who develop a dependency on prescription drugs and distract political attention from public-health oriented solutions, such as increased access to substance abuse recovery treatments.

Study of Online Antidepressant Forums Reveals Long Lasting Withdrawal Effects

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Effects of discontinuing SSRIs and SNRIs reported on an online forum indicate significant and long-lasting withdrawal symptoms.

Experts Call on Presidential Candidates to Improve Study Transparency

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In an open letter to all US presidential candidates published Thursday in the BMJ, a group of global health care experts assert that current research regulations allow drug companies to publish incomplete and misleading results. They ask the candidates to declare whether they support improved transparency measures that would make data on drug studies publically available and open to scrutiny.

FDA Defends Decision to Approve Digital Aripiprazole

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Members of the U.S. Food and Drug Administration’s Psychiatry Products division go on the defensive in a new article, responding to concerns about the agency’s approval of digital aripiprazole.

Two Thirds of Patients See Physicians Who Receive Payments From Pharma

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Study finds more patients are visiting physicians who have ties to industry than previously thought.

“6 Hospitalized, One of Them Brain-Dead, After Drug Trial in France”

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Six men were hospitalized and one was pronounced brain dead after participating in a phase 1 clinical drug for a mood, anxiety, and motor dysfunction drug manufactured by Bial and administered by Biotrial. Carl Elliott, a bioethicist at the University of Minnesota, said investigators should look into questions like how much the men were paid and whether they properly consented to the trial. “Many Phase 1 trial volunteers are poor and unemployed, and they volunteer for trials like this because they are desperate for money,” he said. “This means they are easily exploited.”

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