Open Data

Multiple media sources are reporting on new data from the CDC revealing a substantial increase in the suicide rate in the United States between 1999...

An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

Corruption of pharmaceutical industry sponsored clinical trials identified as a “major obstacle” facing evidence-based medicine.

A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”

A new study demonstrates how the choice of statistical techniques when examining data plays a large role in scientific outcomes.

Reanalysis of the original primary outcome measure in the STAR*D study suggests STAR*D findings inflate improvement on antidepressant medication and exclusion criteria in conventional clinical trials results in overestimation of antidepressant efficacy.

A new study claims that quantitative research in psychology is “worryingly imprecise” and that generalizations may be flawed and misleading.

Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.

An article published this month in the journal BMC Psychiatry suggests that there is a lack of efficacy for SSRIs and that they significantly increase the risk of serious side effects.

A new study, published in the journal Molecular Psychiatry, found no link between genetics and the occurrence of depressive symptoms.

A new study analyzing over 21,000 participants found that differences in activation of brain regions in different psychological “disorders” may have been overestimated, and confirms that there is still no brain scan capable of diagnosing a mental health concern.

The candidate-gene approach to depression goes unsupported and is likely based on bad science, new research finds.

Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.

Prominent researchers conduct a review of antidepressant withdrawal incidence, duration, and severity. Results lead to call for new clinical guidelines.

The authors of a large scale well-conducted systematic review of methylphenidate, also known as Ritalin, conclude that there is a lack of quality evidence for the drug’s effectiveness. Their research also revealed that Ritalin can cause sleep problems and decreased appetite in children.

Researchers report the cumulative effects of major biases on the apparent efficacy of antidepressant and psychotherapy treatments.

More than forty thousand papers have been published using functional magnetic resonance imaging (fMRI) technology to explore the brain. A new analysis of the common...

Last week, well-known Stanford scientist John Ioannidis and his colleague Denes Szucs released a new analysis online. They examined research published in eighteen prominent...

New research suggests that clinicians should exercise caution prescribing SNRIs as first-line treatment for mood and anxiety disorders.

Review of pediatric antidepressant studies finds the vast majority are negative on primary outcomes and an increased risk for suicidality.

Today’s NY Times front page featured a story on the problem reproducibility poses for many psychology studies. The story is based on the results of a year-long study where the researchers found they were unable to reproduce 60 out of 100 studies published in three leading psychology journals. “The overall ‘effect size,’ a measure of the strength of a finding, dropped by about half across all of the studies.”

Researcher criticizes the many ways opposing viewpoints and dissenting voices are squashed in the field of medicine.

The production of modern scientific studies is fundamentally biased and most often leads to unreliable results that no one will be funded to try...

Experts across the globe point to the harms of drug companies’ influence on research, practice, and education in healthcare noting that it compromises patient care.

Jürgen Margraf and Silvia Schneider, both well-known psychologists at the University of Bochum in Germany, claim that psychotropic drugs are no solution to mental...