Sunday, December 8, 2019

Antidepressant Use Climbs as Patients Find it Difficult to Discontinue

Findings point to the role of withdrawal symptoms and prescriber practices in long-term antidepressant use.

Psychological Interventions Can Help When Tapering Off Antidepressants

Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

When Switching Antipsychotics, No Difference Between Immediate and Gradual Discontinuation

Review study compares outcomes of gradual vs. immediate antipsychotic discontinuation when switching from one drug to another.

Antipsychotic Drug Associated with Potentially Fatal Skin Rash

The US Food and Drug Administration is warning the public that the antipsychotic medication ziprasidone "is associated with a rare but serious skin reaction...

New Research on Patient-Centered Deprescribing for Antipsychotics

Researchers review the risks and benefits of deprescribing from antipsychotic drugs and advocate for a patient-centered approach to tapering.

Replacing Pain with Pain: Hazards of Antidepressant Use for Chronic Pain Relief

The paradox of relieving chronic pain with an antidepressant (and a new set of symptoms).

Common Benzodiazepine Sedatives May Induce Aggression

Benzodiazepine medications that are commonly used for calming or sedating people can sometimes apparently cause violent or aggressive responses in some people, according to...

“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity

Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.

STOP or GO? Tapering Pregnant Women off of Antidepressants

A team in the Netherlands is currently investigating the effects of tapering off of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) during pregnancy....

Social Support Improves Antipsychotic Discontinuation, Study Finds

A new study explores how people manage to discontinue antipsychotic medication and examines how social supports may improve outcomes.

New Study Examines Successful Discontinuation of Antipsychotics

A new study to be published in the next issue of Schizophrenia Research examines patients suffering from a first-episode of psychosis who stop taking any antipsychotic drugs. The researchers attempt to identify variables that can serve as predictors of the successful discontinuation of antipsychotics. They find, for example, that those who discontinue the drugs have, on average, the same outcomes as those who stay on them, and that those who have better social integration are more likely to discontinue without relapse.

African American and Hispanic Youth Discontinue ADHD Treatment at Higher Rates than White Youth

Study examines racial and ethnic disparities in the quality of care for Medicaid-enrolled children starting ADHD medication.

Different Antipsychotics Have Different Effects on Brain Volume

First generation antipsychotics seem to cause general brain volume loss, while second generation antipsychotics seem to both increase and decrease the thickness of different parts of the brain.

More Evidence Antidepressants Might Induce Sexual Dysfunction Even After Stopping Them

A retrospective study in the Journal of Clinical Psychiatry examined cases of people who suffered sexual dysfunction that endured even after stopping taking SSRI antidepressants.

Waking Blackouts On Sleep Drugs Can Lead to Dangerous Mishaps

In her blog on USC Annenberg's Reporting on Health, journalist Martha Rosenberg reviews some of the quantitative evidence and qualitatively bizarre anecdotal evidence of...

Smoking Cessation and Psychiatric Drugs Cause the Most Suicidal and Homicidal Reactions

The popular smoking cessation drug Chantix is the medication that most frequently makes people feel suicidal or homicidal, according to figures gathered by the...

Eli Lilly Defeats “Bellwether” Cymbalta Withdrawal Lawsuit

The Federal jury hearing the first of 5000 claims against Eli Lilly for hiding the risks of withdrawal symptoms associated with Cymbalta found that Lilly did not...

Cognitive Function Improved by Reducing Antipsychotics

A 28-week randomized controlled study by researchers in Japan, Canada and the United States finds that a 50% reduction of risperidone or olanzapine significantly...

Major Risks from Drug Interactions in Common Psychiatric Polypharmacy

It is very common for psychiatric patients, especially those diagnosed with schizophrenia, to be prescribed two or more psychiatric medications at once, and this...

Psychiatric Medication Use Associated with Triple the Risk of Stroke

Common psychiatric medications double the risk of heart attack and triple the risk of stroke, according to research presented at the Canadian Cardiovascular Congress...

Autism, Antidepressants, and Pregnancy: The Basics

This month, the seventh study and eighth study came out on the topic of antidepressant exposure during pregnancy and autism.  And these studies showed, as essentially all of the others have, that antidepressant use during pregnancy (principally with selective serotonin reuptake inhibitors or SSRIs) is associated with autism in the exposed children. With so many children being diagnosed with autism and so many women taking antidepressants during pregnancy, everyone wants to know: are these things (the antidepressants) associated with autism or not?  Quite frankly no one has the time to read through all eight scientific papers (and dozens more animal and basic science studies) to understand this important area, so I will do my best to briefly summarize it here.

Pfizer Sued Over Zoloft’s Failure to Beat Placebo

A lawsuit filed Wednesday in San Jose, California seeks federal approval for two class-action lawsuits representing all U.S. users of the antidepressant Zoloft, accusing...

Over One Thousand Boys Grew Breasts “Probably” Caused By Common Psychiatric Medication

According to an ex-chief of the FDA, Johnson & Johnson knew long before it started warning people that Risperdal could cause boys to grow breasts.

Semen Abnormalities Associated with SSRI Antidepressants

The French non-profit organization Prescrire has produced a special report about the impacts of SSRI antidepressants on male fertility.

Antidepressants Linked to Doubling of Failure of Dental Implants

People who take SSRI antidepressants are twice as likely to have their dental implants fail, according to McGill University researchers. In a press release,...

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