Withdrawal Symptoms Cloud Findings of Antidepressant “Relapse” Trial

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Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

More Psychological Supports Needed to Manage Antidepressant Discontinuation

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Study reviews psychological interventions for antidepressant discontinuation.

Certain Antidepressants, Sleep Aids Associated with Higher Dementia Risk

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Greater cumulative doses of drugs that are anticholinergic or block the neurotransmitter acetylcholine are associated with significant increases in dementia and Alzheimer's.

Sudden Antipsychotic Withdrawal—Not Low Dose—Leads to Relapse

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A new article in Lancet Psychiatry debunks past studies claiming that those on low doses of antipsychotics are more likely to relapse.

Psychological Interventions Can Help When Tapering Off Antidepressants

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Meta-analysis of antidepressant tapering finds CBT and MBCT can aid in tapering, but limited studies met inclusion criteria.

Antidepressant Use Climbs as Patients Find it Difficult to Discontinue

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Findings point to the role of withdrawal symptoms and prescriber practices in long-term antidepressant use.

Antidepressant Withdrawal Linked to Suicide Attempt in Case Study

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Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.

No Good Evidence That Antidepressants Prevent Relapse

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Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Strategies for Tapering and Discontinuing Antidepressants

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A new review of strategies to support both patients and practitioners through the process of discontinuing antidepressants.

Lack of Guidance Available for Discontinuing Psychiatric Drugs

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A new article discusses the lack of research dedicated to discontinuing psychiatric drugs and reviews existing strategies.

Gradual Tapering Recommended for Antidepressant Discontinuation

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A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.

Researchers Seek Standardized and Safe Antidepressant Tapering Protocol

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A new study promotes the use of a standardized approach to antidepressant tapering.

Antipsychotic Drug Associated with Potentially Fatal Skin Rash

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The US Food and Drug Administration is warning the public that the antipsychotic medication ziprasidone "is associated with a rare but serious skin reaction...

“Treatment Resistant” Schizophrenia Strongly Linked to Dopamine Supersensitivity

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Over 70% of schizophrenia patients who are "treatment resistant" have apparently developed dopamine supersensitivity psychosis from long-term use of antipsychotic medications.

Cochrane Review Calls for More Research on Antidepressant Withdrawal

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Researchers find a lack of current literature on safe, effective ways to manage antidepressant withdrawal and make suggestions for future research.

New Research on Patient-Centered Deprescribing for Antipsychotics

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Researchers review the risks and benefits of deprescribing from antipsychotic drugs and advocate for a patient-centered approach to tapering.

When Switching Antipsychotics, No Difference Between Immediate and Gradual Discontinuation

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Review study compares outcomes of gradual vs. immediate antipsychotic discontinuation when switching from one drug to another.

Replacing Pain with Pain: Hazards of Antidepressant Use for Chronic Pain Relief

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The paradox of relieving chronic pain with an antidepressant (and a new set of symptoms).

Prescribers Often Fail to Support Patients Discontinuing Antidepressants, Study Finds

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Study reveals most patients are dissatisfied with prescribers' support when discontinuing antidepressants.

Many Service Users Interested in Decreasing Antipsychotic Use with Professional Help

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New research examines service user attitudes on discontinuing and reducing antipsychotic drugs.

Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants

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“Short and simple psychological programs can prevent people from relapsing when they stop their antidepressants.”

“Relapse” in Antidepressant Trials Likely Caused by Sudden Withdrawal

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A new study investigates how antidepressant withdrawal effects often get confounded with depression relapse in clinical trials.

New Study Examines Successful Discontinuation of Antipsychotics

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A new study to be published in the next issue of Schizophrenia Research examines patients suffering from a first-episode of psychosis who stop taking any antipsychotic drugs. The researchers attempt to identify variables that can serve as predictors of the successful discontinuation of antipsychotics. They find, for example, that those who discontinue the drugs have, on average, the same outcomes as those who stay on them, and that those who have better social integration are more likely to discontinue without relapse.
Doctor welcoming a patient

How Providers Can Support Psychiatric Drug Discontinuation

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Supportive patient-practitioner relationships are crucial to the successful discontinuation of psychiatric medication.

Social Support Improves Antipsychotic Discontinuation, Study Finds

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A new study explores how people manage to discontinue antipsychotic medication and examines how social supports may improve outcomes.