Antidepressants

The research literature reveals that antidepressant use in pregnancy poses considerable risks to the fetus and the long-term health of the child. These risks include preterm birth, birth defects, abnormal brain development, and behavioral abnormalities in early childhood.

Throughout the past two decades, studies have warned of increased suicide rates in those taking antidepressants, especially in children and adolescents. Researchers also documented...

A new review, published in BMJ Evidence-Based Medicine, concludes that antidepressants should not be used as the risks outweigh evidence for benefits.

Had I known what I know now, I never would have taken any of these drugs, and I absolutely would not have taken a role in which my outreach efforts to get veterans into mental health treatment might place thousands of lives at risk.

A new study finds poorer depression and anxiety outcomes in psychotherapy for people in economically deprived neighborhoods and those on antidepressants.

An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

We interview Dr. Stuart Shipko, a psychiatrist and author who has a particular interest in the side effects and withdrawal effects of SSRI antidepressants and the need for informed consent when prescribing.

According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.

Researchers suggest that the pharmaceutical industry had a vested interest in using the term “discontinuation” in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.

Selective publication bias in top psychiatry journals was not explained by the quality of the studies, but by financial ties to pharma.

Researchers compared the efficacy of antidepressants using different rating scales and found them to be no different—just slightly better than placebo, and not meeting the criteria for clinical significance.

A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

Moncrieff et al. respond to the contradictory and, in some cases, false concerns raised by these critics of their serotonin review.

In a new study, researchers found no evidence of antidepressant group variance, which means that there's no particular group of patients who improve more than others on the drug.

New research by Jim van Os and Peter Groot finds that using hyperbolic tapering to discontinue antidepressants reduces withdrawal effects.

Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

Adverse physiological symptoms of antidepressant withdrawal are regularly mistaken to be other problems to the detriment of the patient.

Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.

Antidepressants are commonly considered safe and effective treatments. However, research has questioned their efficacy, and now, their safety.

Despite their finding, the researchers suggest that SSRIs be given to people who do not meet criteria for depression or anxiety.

A new study found that having been prescribed an antidepressant previously was associated with an increased risk of depressive relapse.

Bias and financial conflicts in antidepressant trials “contribute to systematic underestimation of risk in the published literature.”

With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.

In this podcast, we hear from the renowned clinician and researcher Dr. Giovanni Fava about his latest book entitled “Discontinuing Antidepressant Medications”.

Common scientific beliefs about serotonin levels in depression and how antidepressants act on the brain appear to be completely backwards.