Antidepressants

In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.

Children's positive responses to SSRI antidepressant treatments for depression are even less significant than adult responses, and do not last beyond four weeks.

Pregnant women taking antidepressant medications, especially during the second trimester, have an increased risk of preeclampsia, a potentially serious or even fatal condition.

Recent claims about antidepressant effectiveness have been based on misleading statements and misunderstandings of the science.

Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

Also, male mice born to mothers with an immune response exhibited “autistic-like” behaviors, scientists report.

Two studies of the effects of antidepressants on sexual function - one on the relative effects across classes of antidepressants on men, the other...

Several years after the information was first revealed, a published study has shown how an influential NIMH study doctored the real data about antidepressants and suicidal events in youth.

Selective serotonin reuptake inhibitors (such as Prozac and Zoloft) are the most commonly prescribed medication for depression. SSRIs have long been associated with an...

The majority of people taking antidepressant medications have never had major depressive disorder, and 38% have never met criteria for having any mental disorder.

According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.

The use of antidepressants has risen quickly among older adults but the rate of depressive symptoms in this population has not declined as a result.

A new study found that taking antidepressants did not improve quality of life.

Researchers review a new synthesis of the existing evidence and conclude that the harms of antidepressants outweigh any benefits.

Researchers at Princeton found that Zoloft accumulates in yeast cells, leading to curvature of the cellular membrane that triggers "autophagy," wherein cells eat themselves...

People who take anticholinergic drugs, such as antidepressants and antipsychotics, are at a 50% higher risk of dementia.

MIA’s Tim Beck interviews Dr. Felicity Thomas and Dr. Richard Byng about their report, Poverty, Pathology, and Pills, which situates increasing rates of mental health diagnosis and psychiatric prescriptions within socioeconomic and policy trends across the UK.

“This is remarkable for drugs that are used to treat depressive symptoms,” write the researchers.

In a new study published in JAMA Psychiatry, researchers investigated whether they could use EEG (electroencephalograph) technology to predict whether people would feel better...

Researchers interviewed people who were given medical advice to discontinue antidepressants.

Alterations in gray matter and white matter development found in infants of mothers taking SSRI antidepressants during pregnancy.

The BMJ’s clinical editor takes issue with uncritical media coverage of antidepressant network meta-analysis, outlining reporting missteps.

Surveyed doctors overestimate pharmacological effects of antidepressants and underestimate placebo effects.

Results from a Cochrane meta-analysis find that the common practice of prescribing antidepressants to treat insomnia is not supported by current evidence.

A review of the scientific literature related to withdrawal from antidepressants: mechanism of action; long-term effects of exposure to antidepressants; discontinuation syndromes; relapse upon discontinuation; tapering protocols.