Saturday, December 4, 2021

Rise of Antipsychotics in Children

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Researchers at Johns Hopkins explore the use of antipsychotics in children, finding a dramatic rise in off-label prescribing with little oversight or research into...

Inappropriate Antipsychotic Prescriptions to Children Keep Increasing

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Clinicians are following best practice guidelines only half of the time when giving antipsychotic medications to children, and following FDA-approved indications only one-fourth of the time.

Study Shows Clozapine Can Result in Serious Gastrointestinal Complications

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A large observational study published in CNS Drugs sheds light on serious adverse effects of the ‘gold standard’ antipsychotic Clozapine.

Common Parkinson’s Drugs Linked to Pathological Gambling and Hypersexuality

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"Pathological gambling, hypersexuality, compulsive shopping and other impulse control disorders were associated with the use of dopamine receptor agonists, often prescribed for Parkinson’s disease,...

“Janssen Accused of Withholding Data on Risperdal Side Effect in Autism”

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MedPageToday reports that Janssen Pharmaceuticals omitted data from a 2003 study that connected Risperdal with serious side effects. Janssen was previously sued by the FDA for marketing Risperdal for off-label uses and settled for $2.2 billion in 2013. Earlier this year, a man with autism was awarded $2.5 million after growing breasts while on Risperdal. According to MedPage, documents from this latest case reveal missing data tables from a 2003 study “designed to ferret out potential adverse effects of long-term risperidone use.” The missing tables were related to elevated prolactin levels and side effects, including gynecomastia in men.

Baseline Lipid Monitoring with Antipsychotics “Disappointingly Low”

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"Even in an academic setting with active discussions among psychiatrists regarding issues of metabolic risk ... baseline lipid monitoring is disappointingly low" according to...

Antipsychotics Associated with White-Matter Reduction

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Researchers in China find an acute reduction in white matter in the frontal lobe following six weeks of antipsychotic treatment for "first-episode schizophrenia". Results...

Psychiatrists’ Prescriptions for First-time Psychosis Often Don’t Follow Guidelines

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"Many patients with first-episode psychosis receive medications that do not comply with recommended guidelines for first-episode treatment," states a National Institute of Mental Health...

Antipsychotics do not Result in Neurocognitive Improvement

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Researchers in London and Spain, in a prospective, randomized, study of long-term (3 year) effects of first- and second-generation antipsychotics on neurocognition in 79...

Mental Health Nurses Do Not Routinely Assess for Effects of Antipsychotic Medications

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Researchers believe that side-effect monitoring is critical because of the increase in the use of antipsychotics

Antipsychotic Risperidone Raises Risk of Male Breast Enlargement

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Taking the antipsychotic medication risperidone significantly increases men's chances of developing gynecomastia, or breast enlargement, according to a study by University of British Columbia...

Alarm About Antipsychotics as Sleep Aids

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Canadian sleep researchers, writing in The Lancet, warn that weight gain, lipid and glucose dysregulation, restless leg syndrome, sleep-walking and eating while asleep, and...

Risk of Death in the Elderly Trebled With Antipsychotics

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In a nine-year study of all 2,224 residents of Leppävirta, Finland who were 65 years old or older, researchers found that the 332 residents...

A History of Rapid Tranquilization

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A paper by Joanna Moncrieff and Laura Allison in the journal History of Psychiatry reviews "the theory and practice of emergency sedation for behavioural...

Osteoporosis Associated with Antipsychotic Treatment

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Chinese researchers find, in a literature review for the International Journal of Endocrinology find an increased rate of osteoporosis among people with a schizophrenia...

Study Reduces Over-prescription of Antipsychotics in Older Adults

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New intervention shows promise in reducing over-prescription of off-label antipsychotics in older adults.

Schizophrenia Prevents Cancer; Antipsychotics May Cause It

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In a review of all 59,233 individuals diagnosed with schizophrenia in Sweden between 1965 and 2008, researchers from Sweden and the U.S. identified 6137...

Increasing Use of Antipsychotics for Disruptive Behavior in Children

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Canadian researchers systematically reviewed all randomized controlled trials of second-generation antipsychotics (SGAs) and placebo in the treatment of disruptive behavior disorders in children, finding...

Antipsychotic Use Does Not Correlate With Conversion to Psychosis

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Researchers in Brazil find, in a meta-analysis, that only 30% of youth deemed to be of ultra high risk of psychosis do in fact...

Antipsychotic Use in Nursing Homes Causing Many Adverse Effects in Elderly

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A literature review found that the extensive off-label use of antipsychotic medications in nursing homes is causing many adverse effects and providing limited benefits.

Seroquel Abuse Rising, Along With Ambulance Calls

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Australian researchers have uncovered an alarming increase of Seroquel-related ambulances calls. Rising prescriptions of of the drug along with its developing use as a drug...

Some Avoid Antipsychotics Because They Value Psychosis

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Side effects, mistrust, stigma, forgetfulness and lack of insight have all been studied as reasons that up to 75% of people with a schizophrenia...

Little Evidence on Effectiveness or Risks of Antipsychotics in Young People

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Evidence-Based Mental Health reviews studies (from 1987 to 2011) of antipsychotics in people under 24 years old, finding weak evidence on comparative effectiveness of antipsychotics or...

Better Recovery and Less Relapse Without Meds: A 20-Year Study

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Researchers at the University of Illinois College of Medicine found, in a 20-year prospective study of 139 psychotic patients, that patients had a far...

APA Recommends Reducing Antipsychotics for Children and Elderly Without Psychosis

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The American Psychiatric Association, as part of the American Board of Internal Medicine's "Choosing Wisely" initiative, released new practice guidelines yesterday that advise against...

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