Antidepressants Not a ‘One Size Fits All’ Solution, Researchers Find
The largest ever study of the thoughts and reactions of antidepressant users reveals that many people have vastly different understandings and experiences of the...
Childhood Trauma Predicts Lack of Response to Antidepressants
Research in Translational Psychiatry finds that childhood maltreatment and trauma predict a greater likelihood of developing chronic depression, and a reduced likelihood of responding to treatment...
Interview: Researchers Deconstruct Ghostwritten Industry Trial for Antidepressant
Researchers, Jon Jureidini, Jay Amsterdam and Leemon McHenry, have taken a closer look at the data from a randomized control trial of citalopram (Celexa) that was ghostwritten and then used by the manufacturers to support claims of the drug’s efficacy and safety in the treatment of child and adolescent depression. To get the background on this story, we connected with Dr. Leemon McHenry, an investigator in this study and a lecturer in philosophy at California State University, Northridge.
Antidepressants Do Not Prevent Suicides, May Increase Risk
When the CDC released data revealing an increasing suicide rate in the US, some experts, speaking to major media outlets, speculated that the increase...
Suicide Rates Rise While Antidepressant Use Climbs
Multiple media sources are reporting on new data from the CDC revealing a substantial increase in the suicide rate in the United States between 1999...
Anticholinergic Drugs, Including Antidepressants, Linked To Later Cognitive Problems
A new study, published in JAMA Neurology, found that older people who regularly took anticholinergic drugs, including certain cold medicines or antidepressants, had poorer...
Legal Journal Says Antidepressants Can Cause Violence and Suicide
Antidepressants have been reported to cause a state called “akathisia,” where people feel extremely agitated and restless and may become preoccupied with thoughts of...
SSRIs in Pregnancy Linked to Early Depression in Children
A new study finds that prenatal exposure to antidepressant drugs, known as selective serotonin reuptake inhibitors or SSRIs, is associated with higher rates of...
Is Increasing Antidepressant Use Contributing to the Obesity Epidemic?
Since the 1980s, antidepressant use has risen by at least four-hundred percent and obesity rates have climbed to include thirty percent of the population....
GSK to Face Class Action over Antidepressants for Children
A Sydney, Australia law firm has launched a class action on behalf of people who as children and adolescents were prescribed Glaxosmithkline's drug Paroxetine. Despite...
Antidepressant Made Germanwings Co-pilot “Panic”
Germanwings pilot Andreas Lubitz wrote, in a desperate, final email to his psychiatrist two weeks before slamming his A320 jet into the French Alps...
Antidepressants Linked to Dementia
A study published in this month’s issue of the Journal of Clinical Psychiatry found that the use of antidepressant drugs was associated with an...
Largest Meta-Analysis of Antidepressants Finds Doubled Risk of Suicide in Youth
The largest-ever meta-analysis of antidepressant trials appeared yesterday in the British Medical Journal. Researchers from the Cochrane Collaboration reviewed 70 trials (involving 18,526 subjects), to find that - counter to the initially-reported findings - antidepressants doubled the risk of suicide and aggression in subjects under 18. This risk had been misrepresented in the original study reports, the authors say, and suggest that the risks to adults may be similarly under-reported.
Antidepressants Increase Brain Bleed Risk
A study published in this month’s issue of Stroke found that antidepressants may increase the risk of microbleeds in the brain. Both SSRI and SNRI antidepressants can disrupt natural clotting mechanisms and lead to increased adverse bleeding incidents and prolonged bleeding times.
Paxil Linked to Birth Defects, Cardiac Malformations
According to the CDC, January is National Birth Defects Prevention Month. New research continues to link various SSRI antidepressants with birth defects and neurological abnormalities in newborns. The latest study to examine this topic, a meta-analysis led by Dr. Anick Bérard, found a 23% increased risk for birth defects, and a 28% increased risk for heart problems, in the infants of women who took the SSRI Paxil (paroxetine) during their first trimester.
Antidepressants Associated with Increased Risk for Manic Symptoms
An analysis of medical records in the UK reveals that the use of certain antidepressants for depression is linked to a heightened risk for mania and bipolar disorder. The research, published this week in BMJ Open, found the strongest effect for serotonin reuptake inhibitors (SSRIs) and the antidepressant venlafaxine.
Maternal Antidepressant Use Tied to Autism
In a major study, published yesterday in JAMA Pediatrics, the use of SSRI antidepressants during pregnancy was found to increase the risk of autism spectrum disorder (ASD) by 87-percent. Previous studies reveal that more than 13-percent of women currently use SSRI antidepressants during pregnancy.
Antidepressants Not More Effective Than Therapy for Major Depression
A new study, published this week in BMJ, found no major differences in the effectiveness of cognitive behavioral therapy (CBT) and antidepressants. When the researchers compared previous studies, they found no major differences in relapse rates or level of treatment response between those taking antidepressants and those undergoing CBT.
After the Black-Box: Majority of Children Starting SSRIs Still Receiving Too High of Dose
In 2004, the FDA added a black-box warning to SSRI antidepressants on the increased risk of suicide among children taking these drugs. A new study suggests that this warning has increased the proportion of children who begin an antidepressant on a low dose, but the majority are still receiving higher than recommended doses.
Light Therapy Outperforms Prozac for Depression
In a new study, researchers found that bright light therapy was an effective treatment for nonseasonal major depressive disorder (MDD) while Prozac (Fluoxetine) alone...
Identifying Psychiatric Drugs Leading to Emergency Room Visits
More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.
SSRIs and Benzodiazepines Associated with Problems in Infants
Infants exposed to SSRIs and benzodiazepines during pregnancy show impaired neurologic functioning in the first month after birth, according to a new study published in the American Journal of Psychiatry. While infants exposed SSRIs alone showed neurobehavioral effects throughout the first month, those exposed to an SSRI and a benzodiazepine had more significant problems.
More Than Two-Thirds of Antidepressants Prescribed Against Guidelines
Results of a new study reveal that sixty-nine percent, or more than two-thirds, of patients prescribed antidepressant drugs have never, in their medical history, met the criteria for major depression. The study, published in the Journal of Clinical Psychiatry this month, also found that several demographic factors, like race and gender, were associated with the prescription of antidepressants.
Brain Response to Antidepressant Mirrors Placebo Effect
People diagnosed with severe depression show the same changes in brain scans when they respond to a placebo as they do when they take an actual antidepressant, according to a new study. Researchers also found that those whose symptoms were decreased by a placebo were more likely to report relief from antidepressant drugs.
SSRI Antidepressants Increase Surgery Risks
There is accumulating evidence that taking SSRI antidepressants increases the risk of bleeding and other complications during surgery, according to a review published in the British Journal of Anaesthesia.
